Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
Hs 578T WYE-125132 1 72
1.0
 982.0 3529.8 873.1
0.0
 0.060 0.278 2.015
Hs578T WYE125132 1
Hs 578T Dactolisib 2 72
1.0
 728.5 3555.0 624.7
0.0
 0.063 0.205 2.509
Hs578T BEZ235 2
HCC38 Dactolisib 3 72
0.1
 1295.5 3265.3 1180.5
-1.0
 0.065 0.397 1.468
HCC38 BEZ235 0 3 72
BT-549 Torin1 3 72
0.32
 1312.5 3974.5 1175.8
-0.495
 0.065 0.330 1.757
BT549 Torin1 0 3 72
Hs 578T Trametinib 3 72
3.2
 684.0 4062.0 571.3
0.505
 0.066 0.168 2.830
Hs578T Trametinib 3
HCC38 Omipalisib 1 72
0.32
 1460.0 4389.3 1295.5
-0.495
 0.070 0.333 1.760
HCC38 GSK458 0 1 72
BT-549 Omipalisib 2 72
0.1
 1429.3 4963.8 1249.6
-1.0
 0.070 0.288 1.990
BT549 GSK458 0 2 72
BT-20 WYE-125132 2 72
0.1
 1155.5 3613.5 1018.6
-1.0
 0.072 0.320 1.827
BT20 WYE125132 0 2
BT-549 WYE-125132 2 72
0.32
 1416.8 4290.8 1249.6
-0.495
 0.073 0.330 1.780
BT549 WYE125132 0 2 72
Hs 578T AZD8055 1 72
3.2
 1005.8 3514.5 873.1
0.505
 0.073 0.286 2.009
Hs578T AZD8055 1
BT-549 AZD8055 3 72
0.32
 1330.5 3973.3 1175.8
-0.495
 0.073 0.335 1.757
BT549 AZD8055 0 3 72
Hs 578T Trametinib 2 72
3.2
 745.8 3491.8 624.7
0.505
 0.074 0.214 2.483
Hs578T Trametinib 2
BT-549 Torin1 3 72
3.2
 1337.3 3974.5 1175.8
0.505
 0.076 0.336 1.757
BT549 Torin1 0 3 72
HCC38 WYE-125132 3 72
0.32
 1313.8 3222.8 1180.5
-0.495
 0.077 0.408 1.449
HCC38 WYE125132 0 3 72
BT-20 AZD8055 3 72
0.32
 709.0 3441.0 586.9
-0.495
 0.077 0.206 2.552
BT20 AZD8055 0 3
BT-549 Torin1 1 72
3.2
 1780.5 5391.5 1554.9
0.505
 0.078 0.330 1.794
BT549 Torin1 0 1 72
BT-549 WYE-125132 2 72
3.2
 1429.3 4290.8 1249.6
0.505
 0.078 0.333 1.780
BT549 WYE125132 0 2 72
Hs 578T Trametinib 2 72
1.0
 753.3 3491.8 624.7
0.0
 0.078 0.216 2.483
Hs578T Trametinib 2
HCC70 Torin2 2 72
0.32
 830.0 2562.3 722.8
-0.495
 0.079 0.324 1.826
HCC70 Torin2 0 2 72
BT-20 Torin2 3 72
0.32
 707.8 3225.3 586.9
-0.495
 0.079 0.219 2.458
BT20 Torin2 0 3
HCC38 Omipalisib 2 72
0.32
 814.8 3009.3 690.5
-0.495
 0.081 0.271 2.124
HCC38 GSK458 0 2 72
Hs 578T WYE-125132 1 72
3.2
 1021.0 3529.8 873.1
0.505
 0.081 0.289 2.015
Hs578T WYE125132 1
HCC38 Torin1 1 72
1.0
 1482.8 4174.3 1295.5
0.0
 0.083 0.355 1.688
HCC38 Torin1 0 1 72
BT-20 Omipalisib 3 72
0.032
 723.0 3523.0 586.9
-1.49
 0.084 0.205 2.586
BT20 GSK458 0 3
BT-549 Torin1 2 72
1.0
 1461.5 4603.3 1249.6
0.0
 0.087 0.317 1.881
BT549 Torin1 0 2 72