Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | Buparlisib | 3 | 72 | 0.32 | 2605.3 | 3388.3 | 586.9 | -0.495 | 0.803 | 0.769 | 2.529 | BT20 BKM120 0 3 |
| BT-20 | BX-912 | 3 | 72 | 0.001 | 3127.5 | 3280.0 | 586.9 | -3.0 | 0.962 | 0.954 | 2.483 | BT20 BX912 0 3 |
| BT-20 | BX-912 | 3 | 72 | 0.0032 | 3155.3 | 3280.0 | 586.9 | -2.49 | 0.969 | 0.962 | 2.483 | BT20 BX912 0 3 |
| BT-20 | BX-912 | 3 | 72 | 0.032 | 3484.8 | 3280.0 | 586.9 | -1.49 | 1.050 | 1.060 | 2.483 | BT20 BX912 0 3 |
| BT-20 | BX-912 | 3 | 72 | 0.1 | 3086.3 | 3280.0 | 586.9 | -1.0 | 0.952 | 0.941 | 2.483 | BT20 BX912 0 3 |
| BT-20 | AS605240 | 3 | 72 | 0.001 | 3319.5 | 3575.0 | 586.9 | -3.0 | 0.944 | 0.929 | 2.607 | BT20 AS605240 0 3 |
| BT-20 | AS605240 | 3 | 72 | 0.0032 | 3254.5 | 3575.0 | 586.9 | -2.49 | 0.929 | 0.910 | 2.607 | BT20 AS605240 0 3 |
| BT-20 | AS605240 | 3 | 72 | 0.032 | 3388.8 | 3575.0 | 586.9 | -1.49 | 0.959 | 0.948 | 2.607 | BT20 AS605240 0 3 |
| BT-20 | AS605240 | 3 | 72 | 0.1 | 3148.5 | 3575.0 | 586.9 | -1.0 | 0.905 | 0.881 | 2.607 | BT20 AS605240 0 3 |
| BT-20 | AS605240 | 3 | 72 | 3.2 | 2896.3 | 3575.0 | 586.9 | 0.505 | 0.845 | 0.810 | 2.607 | BT20 AS605240 0 3 |
| BT-20 | AZD-6482 | 3 | 72 | 0.001 | 3256.8 | 3560.8 | 586.9 | -3.0 | 0.933 | 0.915 | 2.601 | BT20 AZD6482 0 3 |
| BT-20 | AZD-6482 | 3 | 72 | 0.01 | 3282.5 | 3560.8 | 586.9 | -2.0 | 0.938 | 0.922 | 2.601 | BT20 AZD6482 0 3 |
| BT-20 | AZD-6482 | 3 | 72 | 0.032 | 3397.0 | 3560.8 | 586.9 | -1.49 | 0.964 | 0.954 | 2.601 | BT20 AZD6482 0 3 |
| BT-20 | AZD-6482 | 3 | 72 | 3.2 | 1162.3 | 3560.8 | 586.9 | 0.505 | 0.300 | 0.326 | 2.601 | BT20 AZD6482 0 3 |
| BT-20 | AZD8055 | 3 | 72 | 0.001 | 3103.8 | 3441.0 | 586.9 | -3.0 | 0.921 | 0.902 | 2.552 | BT20 AZD8055 0 3 |
| BT-20 | AZD8055 | 3 | 72 | 0.01 | 2824.3 | 3441.0 | 586.9 | -2.0 | 0.851 | 0.821 | 2.552 | BT20 AZD8055 0 3 |
| BT-20 | AZD8055 | 3 | 72 | 0.032 | 1649.5 | 3441.0 | 586.9 | -1.49 | 0.499 | 0.479 | 2.552 | BT20 AZD8055 0 3 |
| BT-20 | AZD8055 | 3 | 72 | 1.0 | 616.8 | 3441.0 | 586.9 | 0.0 | 0.020 | 0.179 | 2.552 | BT20 AZD8055 0 3 |
| BT-20 | AZD8055 | 3 | 72 | 3.2 | 529.0 | 3441.0 | 586.9 | 0.505 | -0.040 | 0.154 | 2.552 | BT20 AZD8055 0 3 |
| BT-20 | Dactolisib | 3 | 72 | 0.0032 | 2424.0 | 3141.3 | 586.9 | -2.49 | 0.797 | 0.772 | 2.420 | BT20 BEZ235 0 3 |
| BT-20 | Dactolisib | 3 | 72 | 0.01 | 1618.0 | 3141.3 | 586.9 | -2.0 | 0.520 | 0.515 | 2.420 | BT20 BEZ235 0 3 |
| BT-20 | Dactolisib | 3 | 72 | 3.2 | 621.5 | 3141.3 | 586.9 | 0.505 | 0.024 | 0.198 | 2.420 | BT20 BEZ235 0 3 |
| BT-20 | Buparlisib | 3 | 72 | 0.001 | 3248.8 | 3388.3 | 586.9 | -3.0 | 0.967 | 0.959 | 2.529 | BT20 BKM120 0 3 |
| BT-20 | Alpelisib | 3 | 72 | 0.0032 | 3274.5 | 3415.3 | 586.9 | -2.49 | 0.967 | 0.959 | 2.541 | BT20 BYL719 0 3 |
| BT-20 | Alpelisib | 3 | 72 | 0.001 | 2642.5 | 3415.3 | 586.9 | -3.0 | 0.808 | 0.774 | 2.541 | BT20 BYL719 0 3 |