Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | Dactolisib | 1 | 72 | 1.0 | 1416.5 | 4578.0 | 1295.5 | 0.0 | 0.050 | 0.309 | 1.821 | HCC38 BEZ235 0 1 72 |
| HCC38 | Dactolisib | 1 | 72 | 0.32 | 1580.5 | 4578.0 | 1295.5 | -0.495 | 0.115 | 0.345 | 1.821 | HCC38 BEZ235 0 1 72 |
| HCC38 | Dactolisib | 1 | 72 | 0.1 | 1706.5 | 4578.0 | 1295.5 | -1.0 | 0.163 | 0.373 | 1.821 | HCC38 BEZ235 0 1 72 |
| HCC38 | Dactolisib | 1 | 72 | 0.032 | 2022.8 | 4578.0 | 1295.5 | -1.49 | 0.277 | 0.442 | 1.821 | HCC38 BEZ235 0 1 72 |
| HCC38 | Dactolisib | 1 | 72 | 0.01 | 2607.8 | 4578.0 | 1295.5 | -2.0 | 0.468 | 0.570 | 1.821 | HCC38 BEZ235 0 1 72 |
| HCC38 | Dactolisib | 1 | 72 | 0.0032 | 3751.5 | 4578.0 | 1295.5 | -2.49 | 0.793 | 0.819 | 1.821 | HCC38 BEZ235 0 1 72 |
| HCC38 | Dactolisib | 1 | 72 | 0.001 | 4156.0 | 4578.0 | 1295.5 | -3.0 | 0.897 | 0.908 | 1.821 | HCC38 BEZ235 0 1 72 |
| HCC38 | AZD8055 | 1 | 72 | 3.2 | 1745.8 | 4427.3 | 1295.5 | 0.505 | 0.183 | 0.394 | 1.773 | HCC38 AZD8055 0 1 72 |
| HCC38 | AZD8055 | 1 | 72 | 1.0 | 1661.8 | 4427.3 | 1295.5 | 0.0 | 0.151 | 0.375 | 1.773 | HCC38 AZD8055 0 1 72 |
| HCC38 | AZD8055 | 1 | 72 | 0.32 | 1747.3 | 4427.3 | 1295.5 | -0.495 | 0.184 | 0.395 | 1.773 | HCC38 AZD8055 0 1 72 |
| HCC38 | AZD8055 | 1 | 72 | 0.1 | 2302.5 | 4427.3 | 1295.5 | -1.0 | 0.383 | 0.520 | 1.773 | HCC38 AZD8055 0 1 72 |
| HCC38 | AZD8055 | 1 | 72 | 0.032 | 3062.0 | 4427.3 | 1295.5 | -1.49 | 0.624 | 0.692 | 1.773 | HCC38 AZD8055 0 1 72 |
| HCC38 | AZD8055 | 1 | 72 | 0.01 | 3709.0 | 4427.3 | 1295.5 | -2.0 | 0.810 | 0.838 | 1.773 | HCC38 AZD8055 0 1 72 |
| HCC38 | AZD8055 | 1 | 72 | 0.0032 | 4191.3 | 4427.3 | 1295.5 | -2.49 | 0.939 | 0.947 | 1.773 | HCC38 AZD8055 0 1 72 |
| HCC38 | AZD8055 | 1 | 72 | 0.001 | 4166.3 | 4427.3 | 1295.5 | -3.0 | 0.933 | 0.941 | 1.773 | HCC38 AZD8055 0 1 72 |
| HCC38 | AZD-6482 | 1 | 72 | 3.2 | 3802.5 | 4304.5 | 1295.5 | 0.505 | 0.862 | 0.883 | 1.732 | HCC38 AZD6482 0 1 72 |
| HCC38 | AZD-6482 | 1 | 72 | 1.0 | 4015.0 | 4304.5 | 1295.5 | 0.0 | 0.921 | 0.933 | 1.732 | HCC38 AZD6482 0 1 72 |
| HCC38 | AZD-6482 | 1 | 72 | 0.32 | 4160.8 | 4304.5 | 1295.5 | -0.495 | 0.961 | 0.967 | 1.732 | HCC38 AZD6482 0 1 72 |
| HCC38 | AZD-6482 | 1 | 72 | 0.1 | 4260.0 | 4304.5 | 1295.5 | -1.0 | 0.988 | 0.990 | 1.732 | HCC38 AZD6482 0 1 72 |
| HCC38 | AZD-6482 | 1 | 72 | 0.032 | 4268.0 | 4304.5 | 1295.5 | -1.49 | 0.990 | 0.992 | 1.732 | HCC38 AZD6482 0 1 72 |
| HCC38 | AZD-6482 | 1 | 72 | 0.01 | 4371.8 | 4304.5 | 1295.5 | -2.0 | 1.020 | 1.020 | 1.732 | HCC38 AZD6482 0 1 72 |
| HCC38 | AZD-6482 | 1 | 72 | 0.0032 | 4430.3 | 4304.5 | 1295.5 | -2.49 | 1.030 | 1.030 | 1.732 | HCC38 AZD6482 0 1 72 |
| HCC38 | AZD-6482 | 1 | 72 | 0.001 | 4232.0 | 4304.5 | 1295.5 | -3.0 | 0.980 | 0.983 | 1.732 | HCC38 AZD6482 0 1 72 |
| HCC38 | AS605240 | 1 | 72 | 3.2 | 3383.3 | 4340.3 | 1295.5 | 0.505 | 0.734 | 0.780 | 1.744 | HCC38 AS605240 0 1 72 |
| HCC38 | AS605240 | 1 | 72 | 1.0 | 3602.0 | 4340.3 | 1295.5 | 0.0 | 0.797 | 0.830 | 1.744 | HCC38 AS605240 0 1 72 |