Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | Torin1 | 3 | 72 | 0.0032 | 2865.5 | 3483.3 | 586.9 | -2.49 | 0.854 | 0.823 | 2.569 | BT20 Torin1 0 3 |
| BT-20 | Torin1 | 3 | 72 | 0.032 | 1460.5 | 3483.3 | 586.9 | -1.49 | 0.426 | 0.419 | 2.569 | BT20 Torin1 0 3 |
| BT-20 | Torin1 | 3 | 72 | 0.1 | 1001.5 | 3483.3 | 586.9 | -1.0 | 0.231 | 0.288 | 2.569 | BT20 Torin1 0 3 |
| BT-20 | Torin2 | 3 | 72 | 0.001 | 2975.8 | 3225.3 | 586.9 | -3.0 | 0.936 | 0.923 | 2.458 | BT20 Torin2 0 3 |
| BT-20 | Torin2 | 3 | 72 | 0.0032 | 2346.0 | 3225.3 | 586.9 | -2.49 | 0.757 | 0.727 | 2.458 | BT20 Torin2 0 3 |
| BT-20 | Torin2 | 3 | 72 | 0.032 | 1034.3 | 3225.3 | 586.9 | -1.49 | 0.259 | 0.321 | 2.458 | BT20 Torin2 0 3 |
| BT-20 | Torin2 | 3 | 72 | 0.1 | 823.5 | 3225.3 | 586.9 | -1.0 | 0.148 | 0.255 | 2.458 | BT20 Torin2 0 3 |
| BT-20 | Torin2 | 3 | 72 | 3.2 | 47.8 | 3225.3 | 586.9 | 0.505 | -0.640 | 0.015 | 2.458 | BT20 Torin2 0 3 |
| BT-20 | Trametinib | 3 | 72 | 0.001 | 3203.3 | 3410.0 | 586.9 | -3.0 | 0.951 | 0.939 | 2.539 | BT20 Trametinib 0 3 |
| BT-20 | Trametinib | 3 | 72 | 0.01 | 2753.3 | 3410.0 | 586.9 | -2.0 | 0.838 | 0.807 | 2.539 | BT20 Trametinib 0 3 |
| BT-20 | Trametinib | 3 | 72 | 0.032 | 2817.0 | 3410.0 | 586.9 | -1.49 | 0.855 | 0.826 | 2.539 | BT20 Trametinib 0 3 |
| BT-20 | WYE-125132 | 3 | 72 | 0.0032 | 2937.3 | 3344.0 | 586.9 | -2.49 | 0.899 | 0.878 | 2.510 | BT20 WYE125132 0 3 |
| BT-20 | WYE-125132 | 3 | 72 | 0.01 | 2864.0 | 3344.0 | 586.9 | -2.0 | 0.880 | 0.856 | 2.510 | BT20 WYE125132 0 3 |
| BT-20 | WYE-125132 | 3 | 72 | 0.1 | 1137.8 | 3344.0 | 586.9 | -1.0 | 0.302 | 0.340 | 2.510 | BT20 WYE125132 0 3 |
| BT-20 | WYE-125132 | 3 | 72 | 0.32 | 917.3 | 3344.0 | 586.9 | -0.495 | 0.195 | 0.274 | 2.510 | BT20 WYE125132 0 3 |
| BT-20 | XL147 | 3 | 72 | 0.001 | 2958.8 | 3677.3 | 586.9 | -3.0 | 0.842 | 0.805 | 2.647 | BT20 XL147 0 3 |
| BT-20 | XL147 | 3 | 72 | 0.0032 | 3135.3 | 3677.3 | 586.9 | -2.49 | 0.883 | 0.853 | 2.647 | BT20 XL147 0 3 |
| BT-20 | XL147 | 3 | 72 | 0.032 | 3323.3 | 3677.3 | 586.9 | -1.49 | 0.925 | 0.904 | 2.647 | BT20 XL147 0 3 |
| BT-20 | XL147 | 3 | 72 | 0.1 | 3310.0 | 3677.3 | 586.9 | -1.0 | 0.922 | 0.900 | 2.647 | BT20 XL147 0 3 |
| BT-20 | ZSTK474 | 3 | 72 | 0.001 | 3277.0 | 3579.5 | 586.9 | -3.0 | 0.933 | 0.915 | 2.609 | BT20 ZSTK474 0 3 |
| BT-20 | ZSTK474 | 3 | 72 | 0.0032 | 3250.5 | 3579.5 | 586.9 | -2.49 | 0.927 | 0.908 | 2.609 | BT20 ZSTK474 0 3 |
| BT-20 | ZSTK474 | 3 | 72 | 0.032 | 3138.0 | 3579.5 | 586.9 | -1.49 | 0.902 | 0.877 | 2.609 | BT20 ZSTK474 0 3 |
| BT-20 | ZSTK474 | 3 | 72 | 0.1 | 2816.5 | 3579.5 | 586.9 | -1.0 | 0.824 | 0.787 | 2.609 | BT20 ZSTK474 0 3 |
| BT-549 | MK2206 | 3 | 72 | 0.032 | 3692.0 | 3781.8 | 1175.8 | -1.49 | 0.972 | 0.976 | 1.685 | BT549 MK2206 0 3 72 |
| BT-549 | MK2206 | 3 | 72 | 0.01 | 3686.5 | 3781.8 | 1175.8 | -2.0 | 0.970 | 0.975 | 1.685 | BT549 MK2206 0 3 72 |