Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | Pictilisib | 3 | 72 | 0.032 | 3393.0 | 3476.3 | 586.9 | -1.49 | 0.981 | 0.976 | 2.566 | BT20 GDC0941 0 3 |
| BT-20 | Pictilisib | 3 | 72 | 0.32 | 2592.0 | 3476.3 | 586.9 | -0.495 | 0.784 | 0.746 | 2.566 | BT20 GDC0941 0 3 |
| BT-20 | Pictilisib | 3 | 72 | 0.1 | 3007.0 | 3476.3 | 586.9 | -1.0 | 0.890 | 0.865 | 2.566 | BT20 GDC0941 0 3 |
| BT-549 | Pictilisib | 3 | 72 | 0.01 | 3887.8 | 4002.3 | 1175.8 | -2.0 | 0.967 | 0.971 | 1.767 | BT549 GDC0941 0 3 72 |
| BT-20 | AZD8055 | 3 | 72 | 0.0032 | 2862.0 | 3441.0 | 586.9 | -2.49 | 0.861 | 0.832 | 2.552 | BT20 AZD8055 0 3 |
| BT-20 | GDC-0980 | 3 | 72 | 0.01 | 3349.8 | 3324.8 | 586.9 | -2.0 | 1.010 | 1.010 | 2.502 | BT20 GDC0980 0 3 |
| BT-20 | GDC-0980 | 3 | 72 | 0.1 | 1475.0 | 3324.8 | 586.9 | -1.0 | 0.445 | 0.444 | 2.502 | BT20 GDC0980 0 3 |
| BT-20 | GDC-0980 | 3 | 72 | 0.32 | 807.5 | 3324.8 | 586.9 | -0.495 | 0.136 | 0.243 | 2.502 | BT20 GDC0980 0 3 |
| BT-20 | Omipalisib | 3 | 72 | 0.001 | 2990.5 | 3523.0 | 586.9 | -3.0 | 0.877 | 0.849 | 2.586 | BT20 GSK458 0 3 |
| BT-20 | Omipalisib | 3 | 72 | 0.0032 | 2230.0 | 3523.0 | 586.9 | -2.49 | 0.676 | 0.633 | 2.586 | BT20 GSK458 0 3 |
| BT-20 | Omipalisib | 3 | 72 | 0.032 | 723.0 | 3523.0 | 586.9 | -1.49 | 0.084 | 0.205 | 2.586 | BT20 GSK458 0 3 |
| BT-20 | Omipalisib | 3 | 72 | 0.1 | 595.3 | 3523.0 | 586.9 | -1.0 | 0.005 | 0.169 | 2.586 | BT20 GSK458 0 3 |
| BT-20 | KIN001-244 | 3 | 72 | 0.001 | 3545.3 | 3578.0 | 586.9 | -3.0 | 0.993 | 0.991 | 2.608 | BT20 KIN001-244 0 3 |
| BT-20 | KIN001-244 | 3 | 72 | 0.0032 | 3514.5 | 3578.0 | 586.9 | -2.49 | 0.986 | 0.982 | 2.608 | BT20 KIN001-244 0 3 |
| BT-20 | KIN001-244 | 3 | 72 | 0.032 | 3246.5 | 3578.0 | 586.9 | -1.49 | 0.927 | 0.907 | 2.608 | BT20 KIN001-244 0 3 |
| BT-20 | KIN001-244 | 3 | 72 | 0.1 | 3371.0 | 3578.0 | 586.9 | -1.0 | 0.955 | 0.942 | 2.608 | BT20 KIN001-244 0 3 |
| BT-20 | KIN001-244 | 3 | 72 | 3.2 | 2882.0 | 3578.0 | 586.9 | 0.505 | 0.841 | 0.805 | 2.608 | BT20 KIN001-244 0 3 |
| BT-20 | MK2206 | 3 | 72 | 0.001 | 3326.5 | 3205.3 | 586.9 | -3.0 | 1.030 | 1.040 | 2.449 | BT20 MK2206 0 3 |
| BT-20 | MK2206 | 3 | 72 | 0.01 | 3164.8 | 3205.3 | 586.9 | -2.0 | 0.990 | 0.987 | 2.449 | BT20 MK2206 0 3 |
| BT-20 | MK2206 | 3 | 72 | 0.032 | 3388.8 | 3205.3 | 586.9 | -1.49 | 1.050 | 1.060 | 2.449 | BT20 MK2206 0 3 |
| BT-20 | PI103 | 3 | 72 | 0.001 | 3081.0 | 3311.5 | 586.9 | -3.0 | 0.943 | 0.930 | 2.496 | BT20 PI103 0 3 |
| BT-20 | PI103 | 3 | 72 | 0.0032 | 3214.5 | 3311.5 | 586.9 | -2.49 | 0.976 | 0.971 | 2.496 | BT20 PI103 0 3 |
| BT-20 | PI103 | 3 | 72 | 0.032 | 3367.3 | 3311.5 | 586.9 | -1.49 | 1.010 | 1.020 | 2.496 | BT20 PI103 0 3 |
| BT-549 | GDC-0980 | 3 | 72 | 0.01 | 3989.3 | 4100.0 | 1175.8 | -2.0 | 0.970 | 0.973 | 1.802 | BT549 GDC0980 0 3 72 |
| BT-549 | GDC-0980 | 3 | 72 | 0.0032 | 3845.3 | 4100.0 | 1175.8 | -2.49 | 0.930 | 0.938 | 1.802 | BT549 GDC0980 0 3 72 |