Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | MK2206 | 2 | 72 | 0.01 | 3314.8 | 3607.8 | 624.7 | -2.0 | 0.934 | 0.919 | 2.530 | Hs578T MK2206 2 |
| Hs 578T | MK2206 | 2 | 72 | 0.032 | 3360.8 | 3607.8 | 624.7 | -1.49 | 0.945 | 0.932 | 2.530 | Hs578T MK2206 2 |
| Hs 578T | MK2206 | 2 | 72 | 0.1 | 3038.5 | 3607.8 | 624.7 | -1.0 | 0.869 | 0.842 | 2.530 | Hs578T MK2206 2 |
| Hs 578T | MK2206 | 2 | 72 | 0.32 | 2629.8 | 3607.8 | 624.7 | -0.495 | 0.765 | 0.729 | 2.530 | Hs578T MK2206 2 |
| Hs 578T | MK2206 | 2 | 72 | 0.0032 | 3583.0 | 3607.8 | 624.7 | -2.49 | 0.995 | 0.993 | 2.530 | Hs578T MK2206 2 |
| Hs 578T | MK2206 | 2 | 72 | 3.2 | 2956.8 | 3607.8 | 624.7 | 0.505 | 0.849 | 0.820 | 2.530 | Hs578T MK2206 2 |
| Hs 578T | MK2206 | 1 | 72 | 3.2 | 2752.8 | 3589.0 | 873.1 | 0.505 | 0.756 | 0.767 | 2.039 | Hs578T MK2206 1 |
| Hs 578T | MK2206 | 1 | 72 | 0.001 | 3510.5 | 3589.0 | 873.1 | -3.0 | 0.978 | 0.978 | 2.039 | Hs578T MK2206 1 |
| Hs 578T | MK2206 | 1 | 72 | 0.01 | 3432.3 | 3589.0 | 873.1 | -2.0 | 0.957 | 0.956 | 2.039 | Hs578T MK2206 1 |
| Hs 578T | MK2206 | 1 | 72 | 0.032 | 3367.8 | 3589.0 | 873.1 | -1.49 | 0.939 | 0.938 | 2.039 | Hs578T MK2206 1 |
| Hs 578T | MK2206 | 1 | 72 | 0.1 | 3000.3 | 3589.0 | 873.1 | -1.0 | 0.832 | 0.836 | 2.039 | Hs578T MK2206 1 |
| Hs 578T | MK2206 | 1 | 72 | 0.32 | 2393.8 | 3589.0 | 873.1 | -0.495 | 0.640 | 0.667 | 2.039 | Hs578T MK2206 1 |
| Hs 578T | MK2206 | 1 | 72 | 1.0 | 2300.8 | 3589.0 | 873.1 | 0.0 | 0.608 | 0.641 | 2.039 | Hs578T MK2206 1 |
| Hs 578T | MK2206 | 1 | 72 | 0.0032 | 3599.3 | 3589.0 | 873.1 | -2.49 | 1.000 | 1.000 | 2.039 | Hs578T MK2206 1 |
| Hs 578T | KIN001-244 | 3 | 72 | 3.2 | 3459.8 | 4230.0 | 571.3 | 0.505 | 0.866 | 0.818 | 2.888 | Hs578T KIN001-244 3 |
| Hs 578T | KIN001-244 | 3 | 72 | 0.32 | 4089.3 | 4230.0 | 571.3 | -0.495 | 0.977 | 0.967 | 2.888 | Hs578T KIN001-244 3 |
| Hs 578T | KIN001-244 | 3 | 72 | 0.1 | 4310.0 | 4230.0 | 571.3 | -1.0 | 1.010 | 1.020 | 2.888 | Hs578T KIN001-244 3 |
| Hs 578T | KIN001-244 | 3 | 72 | 0.001 | 4053.8 | 4230.0 | 571.3 | -3.0 | 0.971 | 0.958 | 2.888 | Hs578T KIN001-244 3 |
| Hs 578T | KIN001-244 | 3 | 72 | 0.0032 | 4381.5 | 4230.0 | 571.3 | -2.49 | 1.020 | 1.040 | 2.888 | Hs578T KIN001-244 3 |
| Hs 578T | KIN001-244 | 3 | 72 | 1.0 | 4018.5 | 4230.0 | 571.3 | 0.0 | 0.965 | 0.950 | 2.888 | Hs578T KIN001-244 3 |
| Hs 578T | KIN001-244 | 3 | 72 | 0.01 | 4310.0 | 4230.0 | 571.3 | -2.0 | 1.010 | 1.020 | 2.888 | Hs578T KIN001-244 3 |
| Hs 578T | KIN001-244 | 3 | 72 | 0.032 | 4396.5 | 4230.0 | 571.3 | -1.49 | 1.030 | 1.040 | 2.888 | Hs578T KIN001-244 3 |
| Hs 578T | KIN001-244 | 2 | 72 | 0.32 | 3488.3 | 3546.3 | 624.7 | -0.495 | 0.987 | 0.984 | 2.505 | Hs578T KIN001-244 2 |
| Hs 578T | KIN001-244 | 2 | 72 | 1.0 | 3240.5 | 3546.3 | 624.7 | 0.0 | 0.929 | 0.914 | 2.505 | Hs578T KIN001-244 2 |
| Hs 578T | KIN001-244 | 2 | 72 | 0.1 | 3550.0 | 3546.3 | 624.7 | -1.0 | 1.000 | 1.000 | 2.505 | Hs578T KIN001-244 2 |