Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | Pictilisib | 3 | 72 | 1.0 | 10951.3 | 11984.0 | 1273.3 | 0.0 | 0.945 | 0.914 | 3.234 | HCC1806 GDC0941 0 3 72 |
| HCC1806 | Pictilisib | 3 | 72 | 0.01 | 11154.5 | 11984.0 | 1273.3 | -2.0 | 0.956 | 0.931 | 3.234 | HCC1806 GDC0941 0 3 72 |
| HCC1806 | Pictilisib | 3 | 72 | 0.032 | 11917.8 | 11984.0 | 1273.3 | -1.49 | 0.997 | 0.994 | 3.234 | HCC1806 GDC0941 0 3 72 |
| HCC1806 | Pictilisib | 3 | 72 | 0.1 | 11495.5 | 11984.0 | 1273.3 | -1.0 | 0.974 | 0.959 | 3.234 | HCC1806 GDC0941 0 3 72 |
| HCC1806 | Pictilisib | 3 | 72 | 0.32 | 11380.8 | 11984.0 | 1273.3 | -0.495 | 0.968 | 0.950 | 3.234 | HCC1806 GDC0941 0 3 72 |
| HCC1806 | Pictilisib | 3 | 72 | 0.001 | 11432.3 | 11984.0 | 1273.3 | -3.0 | 0.971 | 0.954 | 3.234 | HCC1806 GDC0941 0 3 72 |
| HCC1806 | Pictilisib | 3 | 72 | 0.0032 | 11408.5 | 11984.0 | 1273.3 | -2.49 | 0.970 | 0.952 | 3.234 | HCC1806 GDC0941 0 3 72 |
| HCC1806 | Alpelisib | 3 | 72 | 0.32 | 11152.3 | 11894.0 | 1273.3 | -0.495 | 0.960 | 0.938 | 3.224 | HCC1806 BYL719 0 3 72 |
| HCC1806 | Alpelisib | 3 | 72 | 0.1 | 11102.8 | 11894.0 | 1273.3 | -1.0 | 0.958 | 0.933 | 3.224 | HCC1806 BYL719 0 3 72 |
| HCC1806 | Alpelisib | 3 | 72 | 1.0 | 11213.0 | 11894.0 | 1273.3 | 0.0 | 0.964 | 0.943 | 3.224 | HCC1806 BYL719 0 3 72 |
| HCC1806 | Alpelisib | 3 | 72 | 0.0032 | 10690.3 | 11894.0 | 1273.3 | -2.49 | 0.935 | 0.899 | 3.224 | HCC1806 BYL719 0 3 72 |
| HCC1806 | Alpelisib | 3 | 72 | 0.001 | 10768.8 | 11894.0 | 1273.3 | -3.0 | 0.939 | 0.905 | 3.224 | HCC1806 BYL719 0 3 72 |
| HCC1806 | Alpelisib | 3 | 72 | 0.01 | 10822.0 | 11894.0 | 1273.3 | -2.0 | 0.942 | 0.910 | 3.224 | HCC1806 BYL719 0 3 72 |
| HCC1806 | Alpelisib | 3 | 72 | 3.2 | 10596.3 | 11894.0 | 1273.3 | 0.505 | 0.930 | 0.891 | 3.224 | HCC1806 BYL719 0 3 72 |
| HCC1806 | Alpelisib | 3 | 72 | 0.032 | 11055.0 | 11894.0 | 1273.3 | -1.49 | 0.955 | 0.929 | 3.224 | HCC1806 BYL719 0 3 72 |
| HCC1806 | Omipalisib | 3 | 72 | 0.32 | 3470.8 | 11840.0 | 1273.3 | -0.495 | 0.366 | 0.293 | 3.217 | HCC1806 GSK458 0 3 72 |
| HCC1806 | Omipalisib | 3 | 72 | 3.2 | 569.3 | 11840.0 | 1273.3 | 0.505 | -0.221 | 0.048 | 3.217 | HCC1806 GSK458 0 3 72 |
| HCC1806 | Omipalisib | 3 | 72 | 1.0 | 1813.3 | 11840.0 | 1273.3 | 0.0 | 0.116 | 0.153 | 3.217 | HCC1806 GSK458 0 3 72 |
| HCC1806 | Omipalisib | 3 | 72 | 0.01 | 10689.3 | 11840.0 | 1273.3 | -2.0 | 0.937 | 0.903 | 3.217 | HCC1806 GSK458 0 3 72 |
| HCC1806 | Omipalisib | 3 | 72 | 0.032 | 7012.3 | 11840.0 | 1273.3 | -1.49 | 0.699 | 0.592 | 3.217 | HCC1806 GSK458 0 3 72 |
| HCC1806 | Omipalisib | 3 | 72 | 0.001 | 10878.5 | 11840.0 | 1273.3 | -3.0 | 0.948 | 0.919 | 3.217 | HCC1806 GSK458 0 3 72 |
| HCC1806 | Omipalisib | 3 | 72 | 0.0032 | 11552.0 | 11840.0 | 1273.3 | -2.49 | 0.985 | 0.976 | 3.217 | HCC1806 GSK458 0 3 72 |
| HCC1806 | Omipalisib | 3 | 72 | 0.1 | 4476.3 | 11840.0 | 1273.3 | -1.0 | 0.478 | 0.378 | 3.217 | HCC1806 GSK458 0 3 72 |
| HCC1806 | Torin2 | 3 | 72 | 1.0 | 999.5 | 11795.0 | 1273.3 | 0.0 | -0.073 | 0.085 | 3.212 | HCC1806 Torin2 0 3 72 |
| HCC1806 | Torin2 | 3 | 72 | 0.032 | 7731.3 | 11795.0 | 1273.3 | -1.49 | 0.754 | 0.655 | 3.212 | HCC1806 Torin2 0 3 72 |