Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | WYE-125132 | 3 | 72 | 1.0 | 1048.5 | 4195.3 | 571.3 | 0.0 | 0.235 | 0.250 | 2.876 | Hs578T WYE125132 3 |
| Hs 578T | WYE-125132 | 3 | 72 | 0.1 | 1489.8 | 4195.3 | 571.3 | -1.0 | 0.395 | 0.355 | 2.876 | Hs578T WYE125132 3 |
| Hs 578T | WYE-125132 | 3 | 72 | 0.032 | 2208.3 | 4195.3 | 571.3 | -1.49 | 0.600 | 0.526 | 2.876 | Hs578T WYE125132 3 |
| Hs 578T | WYE-125132 | 3 | 72 | 0.01 | 3335.5 | 4195.3 | 571.3 | -2.0 | 0.847 | 0.795 | 2.876 | Hs578T WYE125132 3 |
| Hs 578T | WYE-125132 | 3 | 72 | 0.0032 | 3689.8 | 4195.3 | 571.3 | -2.49 | 0.913 | 0.880 | 2.876 | Hs578T WYE125132 3 |
| Hs 578T | WYE-125132 | 3 | 72 | 0.001 | 3852.0 | 4195.3 | 571.3 | -3.0 | 0.942 | 0.918 | 2.876 | Hs578T WYE125132 3 |
| HCC1806 | WYE-125132 | 2 | 72 | 0.001 | 11365.0 | 12050.8 | 1643.3 | -3.0 | 0.960 | 0.943 | 2.874 | HCC1806 WYE125132 0 2 72 |
| Hs 578T | CAL-101 | 3 | 72 | 3.2 | 3370.5 | 4189.5 | 571.3 | 0.505 | 0.854 | 0.805 | 2.874 | Hs578T CAL101 3 |
| Hs 578T | CAL-101 | 3 | 72 | 0.032 | 4226.0 | 4189.5 | 571.3 | -1.49 | 1.010 | 1.010 | 2.874 | Hs578T CAL101 3 |
| HCC1806 | WYE-125132 | 2 | 72 | 0.32 | 5594.8 | 12050.8 | 1643.3 | -0.495 | 0.531 | 0.464 | 2.874 | HCC1806 WYE125132 0 2 72 |
| Hs 578T | CAL-101 | 3 | 72 | 0.0032 | 4192.0 | 4189.5 | 571.3 | -2.49 | 1.000 | 1.000 | 2.874 | Hs578T CAL101 3 |
| HCC1806 | WYE-125132 | 2 | 72 | 0.1 | 6801.8 | 12050.8 | 1643.3 | -1.0 | 0.639 | 0.564 | 2.874 | HCC1806 WYE125132 0 2 72 |
| Hs 578T | CAL-101 | 3 | 72 | 0.01 | 4238.3 | 4189.5 | 571.3 | -2.0 | 1.010 | 1.010 | 2.874 | Hs578T CAL101 3 |
| Hs 578T | CAL-101 | 3 | 72 | 0.1 | 4231.8 | 4189.5 | 571.3 | -1.0 | 1.010 | 1.010 | 2.874 | Hs578T CAL101 3 |
| HCC1806 | WYE-125132 | 2 | 72 | 1.0 | 5290.0 | 12050.8 | 1643.3 | 0.0 | 0.502 | 0.439 | 2.874 | HCC1806 WYE125132 0 2 72 |
| Hs 578T | CAL-101 | 3 | 72 | 0.32 | 4090.8 | 4189.5 | 571.3 | -0.495 | 0.983 | 0.976 | 2.874 | Hs578T CAL101 3 |
| HCC1806 | WYE-125132 | 2 | 72 | 0.0032 | 11072.0 | 12050.8 | 1643.3 | -2.49 | 0.942 | 0.919 | 2.874 | HCC1806 WYE125132 0 2 72 |
| HCC1806 | WYE-125132 | 2 | 72 | 0.01 | 10352.8 | 12050.8 | 1643.3 | -2.0 | 0.897 | 0.859 | 2.874 | HCC1806 WYE125132 0 2 72 |
| HCC1806 | WYE-125132 | 2 | 72 | 3.2 | 5062.8 | 12050.8 | 1643.3 | 0.505 | 0.479 | 0.420 | 2.874 | HCC1806 WYE125132 0 2 72 |
| Hs 578T | CAL-101 | 3 | 72 | 0.001 | 4189.5 | 4189.5 | 571.3 | -3.0 | 1.000 | 1.000 | 2.874 | Hs578T CAL101 3 |
| HCC1806 | WYE-125132 | 2 | 72 | 0.032 | 8601.3 | 12050.8 | 1643.3 | -1.49 | 0.779 | 0.714 | 2.874 | HCC1806 WYE125132 0 2 72 |
| Hs 578T | CAL-101 | 3 | 72 | 1.0 | 3764.0 | 4189.5 | 571.3 | 0.0 | 0.927 | 0.898 | 2.874 | Hs578T CAL101 3 |
| HCC1806 | Everolimus | 2 | 72 | 0.32 | 9042.0 | 12020.5 | 1643.3 | -0.495 | 0.811 | 0.752 | 2.871 | HCC1806 Everolimus 0 2 72 |
| HCC1806 | Everolimus | 2 | 72 | 1.0 | 8742.8 | 12020.5 | 1643.3 | 0.0 | 0.790 | 0.727 | 2.871 | HCC1806 Everolimus 0 2 72 |
| HCC1806 | Everolimus | 2 | 72 | 0.1 | 9054.3 | 12020.5 | 1643.3 | -1.0 | 0.812 | 0.753 | 2.871 | HCC1806 Everolimus 0 2 72 |