Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | Buparlisib | 1 | 72 | 0.32 | 2526.8 | 3651.8 | 873.1 | -0.495 | 0.673 | 0.692 | 2.064 | Hs578T BKM120 1 |
| Hs 578T | BX-912 | 1 | 72 | 0.001 | 3608.5 | 3493.8 | 873.1 | -3.0 | 1.030 | 1.030 | 2.001 | Hs578T BX912 1 |
| Hs 578T | BX-912 | 1 | 72 | 0.0032 | 3647.8 | 3493.8 | 873.1 | -2.49 | 1.040 | 1.040 | 2.001 | Hs578T BX912 1 |
| Hs 578T | BX-912 | 1 | 72 | 0.032 | 3582.3 | 3493.8 | 873.1 | -1.49 | 1.030 | 1.030 | 2.001 | Hs578T BX912 1 |
| Hs 578T | BX-912 | 1 | 72 | 0.1 | 3418.5 | 3493.8 | 873.1 | -1.0 | 0.978 | 0.978 | 2.001 | Hs578T BX912 1 |
| Hs 578T | AS605240 | 1 | 72 | 0.001 | 3614.8 | 3529.0 | 873.1 | -3.0 | 1.020 | 1.020 | 2.015 | Hs578T AS605240 1 |
| Hs 578T | AS605240 | 1 | 72 | 0.0032 | 3474.3 | 3529.0 | 873.1 | -2.49 | 0.985 | 0.984 | 2.015 | Hs578T AS605240 1 |
| Hs 578T | AS605240 | 1 | 72 | 0.032 | 3287.8 | 3529.0 | 873.1 | -1.49 | 0.931 | 0.932 | 2.015 | Hs578T AS605240 1 |
| Hs 578T | AS605240 | 1 | 72 | 0.1 | 2796.0 | 3529.0 | 873.1 | -1.0 | 0.782 | 0.792 | 2.015 | Hs578T AS605240 1 |
| Hs 578T | AS605240 | 1 | 72 | 3.2 | 1577.8 | 3529.0 | 873.1 | 0.505 | 0.341 | 0.447 | 2.015 | Hs578T AS605240 1 |
| Hs 578T | AZD-6482 | 1 | 72 | 0.001 | 3637.3 | 3592.0 | 873.1 | -3.0 | 1.010 | 1.010 | 2.041 | Hs578T AZD6482 1 |
| Hs 578T | AZD-6482 | 1 | 72 | 0.01 | 3401.5 | 3592.0 | 873.1 | -2.0 | 0.947 | 0.947 | 2.041 | Hs578T AZD6482 1 |
| Hs 578T | AZD-6482 | 1 | 72 | 0.032 | 3304.0 | 3592.0 | 873.1 | -1.49 | 0.920 | 0.920 | 2.041 | Hs578T AZD6482 1 |
| Hs 578T | AZD-6482 | 1 | 72 | 3.2 | 1737.5 | 3592.0 | 873.1 | 0.505 | 0.401 | 0.484 | 2.041 | Hs578T AZD6482 1 |
| Hs 578T | AZD8055 | 1 | 72 | 0.001 | 3425.5 | 3514.5 | 873.1 | -3.0 | 0.975 | 0.975 | 2.009 | Hs578T AZD8055 1 |
| Hs 578T | AZD8055 | 1 | 72 | 0.01 | 2770.8 | 3514.5 | 873.1 | -2.0 | 0.777 | 0.788 | 2.009 | Hs578T AZD8055 1 |
| Hs 578T | AZD8055 | 1 | 72 | 0.032 | 2220.5 | 3514.5 | 873.1 | -1.49 | 0.591 | 0.632 | 2.009 | Hs578T AZD8055 1 |
| Hs 578T | AZD8055 | 1 | 72 | 1.0 | 1056.5 | 3514.5 | 873.1 | 0.0 | 0.100 | 0.301 | 2.009 | Hs578T AZD8055 1 |
| Hs 578T | AZD8055 | 1 | 72 | 3.2 | 1005.8 | 3514.5 | 873.1 | 0.505 | 0.073 | 0.286 | 2.009 | Hs578T AZD8055 1 |
| Hs 578T | Dactolisib | 1 | 72 | 0.0032 | 2819.5 | 3608.8 | 873.1 | -2.49 | 0.773 | 0.781 | 2.047 | Hs578T BEZ235 1 |
| Hs 578T | Dactolisib | 1 | 72 | 0.01 | 1815.0 | 3608.8 | 873.1 | -2.0 | 0.430 | 0.503 | 2.047 | Hs578T BEZ235 1 |
| Hs 578T | Dactolisib | 1 | 72 | 3.2 | 768.3 | 3608.8 | 873.1 | 0.505 | -0.061 | 0.213 | 2.047 | Hs578T BEZ235 1 |
| Hs 578T | Buparlisib | 1 | 72 | 0.001 | 3598.5 | 3651.8 | 873.1 | -3.0 | 0.986 | 0.985 | 2.064 | Hs578T BKM120 1 |
| Hs 578T | Alpelisib | 1 | 72 | 0.0032 | 3187.3 | 3736.0 | 873.1 | -2.49 | 0.854 | 0.853 | 2.097 | Hs578T BYL719 1 |
| Hs 578T | Alpelisib | 1 | 72 | 0.001 | 3568.3 | 3736.0 | 873.1 | -3.0 | 0.957 | 0.955 | 2.097 | Hs578T BYL719 1 |