Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | KIN001-244 | 3 | 72 | 0.001 | 11912.3 | 11660.3 | 1273.3 | -3.0 | 1.010 | 1.020 | 3.195 | HCC1806 KIN001-244 0 3 72 |
| HCC1806 | KIN001-244 | 1 | 72 | 0.001 | 11912.3 | 11660.3 | 1742.8 | -3.0 | 1.020 | 1.020 | 2.742 | HCC1806 KIN001-244 0 1 72 |
| HCC1806 | ZSTK474 | 3 | 72 | 0.032 | 11901.8 | 11395.8 | 1273.3 | -1.49 | 1.030 | 1.040 | 3.162 | HCC1806 ZSTK474 0 3 72 |
| HCC1806 | ZSTK474 | 2 | 72 | 0.032 | 11901.8 | 11395.8 | 1643.3 | -1.49 | 1.030 | 1.040 | 2.794 | HCC1806 ZSTK474 0 2 72 |
| HCC1806 | ZSTK474 | 1 | 72 | 0.032 | 11901.8 | 11395.8 | 1742.8 | -1.49 | 1.030 | 1.040 | 2.709 | HCC1806 ZSTK474 0 1 72 |
| HCC1806 | AZD-6482 | 3 | 72 | 1.0 | 11781.3 | 11709.8 | 1273.3 | 0.0 | 1.000 | 1.010 | 3.201 | HCC1806 AZD6482 0 3 72 |
| HCC1806 | AZD-6482 | 1 | 72 | 1.0 | 11781.3 | 11709.8 | 1742.8 | 0.0 | 1.000 | 1.010 | 2.748 | HCC1806 AZD6482 0 1 72 |
| HCC1806 | AZD-6482 | 2 | 72 | 1.0 | 11781.3 | 11709.8 | 1643.3 | 0.0 | 1.000 | 1.010 | 2.833 | HCC1806 AZD6482 0 2 72 |
| HCC1806 | BX-912 | 3 | 72 | 0.0032 | 11758.0 | 11641.0 | 1273.3 | -2.49 | 1.010 | 1.010 | 3.193 | HCC1806 BX912 0 3 72 |
| HCC1806 | BX-912 | 2 | 72 | 0.0032 | 11758.0 | 11641.0 | 1643.3 | -2.49 | 1.010 | 1.010 | 2.825 | HCC1806 BX912 0 2 72 |
| HCC1806 | BX-912 | 1 | 72 | 0.0032 | 11758.0 | 11641.0 | 1742.8 | -2.49 | 1.010 | 1.010 | 2.740 | HCC1806 BX912 0 1 72 |
| HCC1806 | PI103 | 2 | 72 | 0.032 | 11750.3 | 11113.3 | 1643.3 | -1.49 | 1.040 | 1.060 | 2.758 | HCC1806 PI103 0 2 72 |
| HCC1806 | PI103 | 1 | 72 | 0.032 | 11750.3 | 11113.3 | 1742.8 | -1.49 | 1.040 | 1.060 | 2.673 | HCC1806 PI103 0 1 72 |
| HCC1806 | PI103 | 3 | 72 | 0.032 | 11750.3 | 11113.3 | 1273.3 | -1.49 | 1.040 | 1.060 | 3.126 | HCC1806 PI103 0 3 72 |
| HCC1806 | BX-912 | 3 | 72 | 0.032 | 11715.5 | 11641.0 | 1273.3 | -1.49 | 1.000 | 1.010 | 3.193 | HCC1806 BX912 0 3 72 |
| HCC1806 | BX-912 | 1 | 72 | 0.032 | 11715.5 | 11641.0 | 1742.8 | -1.49 | 1.000 | 1.010 | 2.740 | HCC1806 BX912 0 1 72 |
| HCC1806 | BX-912 | 2 | 72 | 0.032 | 11715.5 | 11641.0 | 1643.3 | -1.49 | 1.000 | 1.010 | 2.825 | HCC1806 BX912 0 2 72 |
| HCC1806 | AS605240 | 2 | 72 | 0.1 | 11678.3 | 11546.3 | 1643.3 | -1.0 | 1.010 | 1.010 | 2.813 | HCC1806 AS605240 0 2 72 |
| HCC1806 | AS605240 | 1 | 72 | 0.1 | 11678.3 | 11546.3 | 1742.8 | -1.0 | 1.010 | 1.010 | 2.728 | HCC1806 AS605240 0 1 72 |
| HCC1806 | AS605240 | 3 | 72 | 0.1 | 11678.3 | 11546.3 | 1273.3 | -1.0 | 1.010 | 1.010 | 3.181 | HCC1806 AS605240 0 3 72 |
| HCC1806 | PI103 | 3 | 72 | 0.01 | 11663.8 | 11113.3 | 1273.3 | -2.0 | 1.030 | 1.050 | 3.126 | HCC1806 PI103 0 3 72 |
| HCC1806 | PI103 | 2 | 72 | 0.01 | 11663.8 | 11113.3 | 1643.3 | -2.0 | 1.040 | 1.050 | 2.758 | HCC1806 PI103 0 2 72 |
| HCC1806 | PI103 | 1 | 72 | 0.01 | 11663.8 | 11113.3 | 1742.8 | -2.0 | 1.040 | 1.050 | 2.673 | HCC1806 PI103 0 1 72 |
| HCC1806 | PIK-93 | 3 | 72 | 0.001 | 11663.0 | 11752.8 | 1273.3 | -3.0 | 0.995 | 0.992 | 3.206 | HCC1806 PIK93 0 3 72 |
| HCC1806 | PIK-93 | 1 | 72 | 0.001 | 11663.0 | 11752.8 | 1742.8 | -3.0 | 0.994 | 0.992 | 2.753 | HCC1806 PIK93 0 1 72 |