Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | TGX221 | 2 | 72 | 1.0 | 11205.8 | 11158.5 | 1643.3 | 0.0 | 1.000 | 1.000 | 2.763 | HCC1806 TGX221 0 2 72 |
| HCC1806 | TGX221 | 3 | 72 | 1.0 | 11205.8 | 11158.5 | 1273.3 | 0.0 | 1.000 | 1.000 | 3.132 | HCC1806 TGX221 0 3 72 |
| HCC1806 | PIK-93 | 1 | 72 | 0.0032 | 11204.3 | 11752.8 | 1742.8 | -2.49 | 0.966 | 0.953 | 2.753 | HCC1806 PIK93 0 1 72 |
| HCC1806 | PIK-93 | 3 | 72 | 0.0032 | 11204.3 | 11752.8 | 1273.3 | -2.49 | 0.970 | 0.953 | 3.206 | HCC1806 PIK93 0 3 72 |
| HCC1806 | PIK-93 | 2 | 72 | 0.0032 | 11204.3 | 11752.8 | 1643.3 | -2.49 | 0.967 | 0.953 | 2.838 | HCC1806 PIK93 0 2 72 |
| HCC1806 | TGX221 | 1 | 72 | 0.0032 | 11187.8 | 11158.5 | 1742.8 | -2.49 | 1.000 | 1.000 | 2.679 | HCC1806 TGX221 0 1 72 |
| HCC1806 | TGX221 | 2 | 72 | 0.0032 | 11187.8 | 11158.5 | 1643.3 | -2.49 | 1.000 | 1.000 | 2.763 | HCC1806 TGX221 0 2 72 |
| HCC1806 | TGX221 | 3 | 72 | 0.0032 | 11187.8 | 11158.5 | 1273.3 | -2.49 | 1.000 | 1.000 | 3.132 | HCC1806 TGX221 0 3 72 |
| HCC1806 | PI103 | 2 | 72 | 0.0032 | 11168.3 | 11113.3 | 1643.3 | -2.49 | 1.000 | 1.000 | 2.758 | HCC1806 PI103 0 2 72 |
| HCC1806 | PI103 | 1 | 72 | 0.0032 | 11168.3 | 11113.3 | 1742.8 | -2.49 | 1.000 | 1.000 | 2.673 | HCC1806 PI103 0 1 72 |
| HCC1806 | PI103 | 3 | 72 | 0.0032 | 11168.3 | 11113.3 | 1273.3 | -2.49 | 1.000 | 1.000 | 3.126 | HCC1806 PI103 0 3 72 |
| HCC1806 | Torin2 | 1 | 72 | 0.0032 | 11163.3 | 11795.0 | 1742.8 | -2.49 | 0.960 | 0.946 | 2.759 | HCC1806 Torin2 0 1 72 |
| HCC1806 | Torin2 | 3 | 72 | 0.0032 | 11163.3 | 11795.0 | 1273.3 | -2.49 | 0.966 | 0.946 | 3.212 | HCC1806 Torin2 0 3 72 |
| HCC1806 | Torin2 | 2 | 72 | 0.0032 | 11163.3 | 11795.0 | 1643.3 | -2.49 | 0.962 | 0.946 | 2.843 | HCC1806 Torin2 0 2 72 |
| HCC1806 | AZD8055 | 3 | 72 | 0.0032 | 11161.5 | 11579.3 | 1273.3 | -2.49 | 0.977 | 0.964 | 3.185 | HCC1806 AZD8055 0 3 72 |
| HCC1806 | AZD8055 | 2 | 72 | 0.0032 | 11161.5 | 11579.3 | 1643.3 | -2.49 | 0.974 | 0.964 | 2.817 | HCC1806 AZD8055 0 2 72 |
| HCC1806 | AZD8055 | 1 | 72 | 0.0032 | 11161.5 | 11579.3 | 1742.8 | -2.49 | 0.973 | 0.964 | 2.732 | HCC1806 AZD8055 0 1 72 |
| HCC1806 | Pictilisib | 3 | 72 | 0.01 | 11154.5 | 11984.0 | 1273.3 | -2.0 | 0.956 | 0.931 | 3.234 | HCC1806 GDC0941 0 3 72 |
| HCC1806 | Pictilisib | 2 | 72 | 0.01 | 11154.5 | 11984.0 | 1643.3 | -2.0 | 0.951 | 0.931 | 2.866 | HCC1806 GDC0941 0 2 72 |
| HCC1806 | Pictilisib | 1 | 72 | 0.01 | 11154.5 | 11984.0 | 1742.8 | -2.0 | 0.949 | 0.931 | 2.782 | HCC1806 GDC0941 0 1 72 |
| HCC1806 | Alpelisib | 1 | 72 | 0.32 | 11152.3 | 11894.0 | 1742.8 | -0.495 | 0.954 | 0.938 | 2.771 | HCC1806 BYL719 0 1 72 |
| HCC1806 | Alpelisib | 2 | 72 | 0.32 | 11152.3 | 11894.0 | 1643.3 | -0.495 | 0.955 | 0.938 | 2.856 | HCC1806 BYL719 0 2 72 |
| HCC1806 | Alpelisib | 3 | 72 | 0.32 | 11152.3 | 11894.0 | 1273.3 | -0.495 | 0.960 | 0.938 | 3.224 | HCC1806 BYL719 0 3 72 |
| HCC1806 | Torin1 | 2 | 72 | 0.0032 | 11138.3 | 11764.8 | 1643.3 | -2.49 | 0.962 | 0.947 | 2.840 | HCC1806 Torin1 0 2 72 |
| HCC1806 | Torin1 | 3 | 72 | 0.0032 | 11138.3 | 11764.8 | 1273.3 | -2.49 | 0.966 | 0.947 | 3.208 | HCC1806 Torin1 0 3 72 |