Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | Alpelisib | 1 | 72 | 0.032 | 5912.0 | 6091.5 | 1443.3 | -1.49 | 0.971 | 0.971 | 2.077 | BT20 BYL719 0 1 |
| BT-20 | Alpelisib | 1 | 72 | 0.1 | 5660.0 | 6091.5 | 1443.3 | -1.0 | 0.931 | 0.929 | 2.077 | BT20 BYL719 0 1 |
| BT-20 | Alpelisib | 1 | 72 | 0.32 | 5140.8 | 6091.5 | 1443.3 | -0.495 | 0.843 | 0.844 | 2.077 | BT20 BYL719 0 1 |
| BT-20 | Alpelisib | 1 | 72 | 1.0 | 3559.0 | 6091.5 | 1443.3 | 0.0 | 0.544 | 0.584 | 2.077 | BT20 BYL719 0 1 |
| BT-20 | Alpelisib | 1 | 72 | 3.2 | 1584.5 | 6091.5 | 1443.3 | 0.505 | 0.046 | 0.260 | 2.077 | BT20 BYL719 0 1 |
| BT-20 | Alpelisib | 3 | 72 | 0.01 | 3139.5 | 3415.3 | 586.9 | -2.0 | 0.935 | 0.919 | 2.541 | BT20 BYL719 0 3 |
| BT-20 | Alpelisib | 3 | 72 | 0.0032 | 3274.5 | 3415.3 | 586.9 | -2.49 | 0.967 | 0.959 | 2.541 | BT20 BYL719 0 3 |
| BT-20 | Alpelisib | 3 | 72 | 3.2 | 930.3 | 3415.3 | 586.9 | 0.505 | 0.199 | 0.272 | 2.541 | BT20 BYL719 0 3 |
| BT-20 | Alpelisib | 3 | 72 | 0.032 | 2758.3 | 3415.3 | 586.9 | -1.49 | 0.839 | 0.808 | 2.541 | BT20 BYL719 0 3 |
| BT-20 | Alpelisib | 3 | 72 | 1.0 | 1703.0 | 3415.3 | 586.9 | 0.0 | 0.521 | 0.499 | 2.541 | BT20 BYL719 0 3 |
| BT-20 | Alpelisib | 3 | 72 | 0.32 | 2797.8 | 3415.3 | 586.9 | -0.495 | 0.849 | 0.819 | 2.541 | BT20 BYL719 0 3 |
| BT-20 | Alpelisib | 3 | 72 | 0.1 | 3078.5 | 3415.3 | 586.9 | -1.0 | 0.920 | 0.901 | 2.541 | BT20 BYL719 0 3 |
| BT-549 | Alpelisib | 1 | 72 | 0.001 | 5371.8 | 5499.0 | 1554.9 | -3.0 | 0.974 | 0.977 | 1.822 | BT549 BYL719 0 1 72 |
| BT-20 | Alpelisib | 2 | 72 | 0.01 | 3212.8 | 3290.8 | 1018.6 | -2.0 | 0.972 | 0.976 | 1.692 | BT20 BYL719 0 2 |
| BT-549 | Alpelisib | 2 | 72 | 0.0032 | 4897.0 | 4752.0 | 1249.6 | -2.49 | 1.030 | 1.030 | 1.927 | BT549 BYL719 0 2 72 |
| BT-549 | Alpelisib | 2 | 72 | 0.01 | 4783.8 | 4752.0 | 1249.6 | -2.0 | 1.010 | 1.010 | 1.927 | BT549 BYL719 0 2 72 |
| BT-549 | Alpelisib | 2 | 72 | 0.32 | 4462.5 | 4752.0 | 1249.6 | -0.495 | 0.936 | 0.939 | 1.927 | BT549 BYL719 0 2 72 |
| BT-549 | Alpelisib | 2 | 72 | 1.0 | 4414.5 | 4752.0 | 1249.6 | 0.0 | 0.925 | 0.929 | 1.927 | BT549 BYL719 0 2 72 |
| BT-20 | Alpelisib | 2 | 72 | 3.2 | 853.3 | 3290.8 | 1018.6 | 0.505 | -0.099 | 0.259 | 1.692 | BT20 BYL719 0 2 |
| BT-20 | Alpelisib | 2 | 72 | 0.0032 | 2510.5 | 3290.8 | 1018.6 | -2.49 | 0.704 | 0.763 | 1.692 | BT20 BYL719 0 2 |
| BT-20 | Alpelisib | 2 | 72 | 1.0 | 1205.3 | 3290.8 | 1018.6 | 0.0 | 0.105 | 0.366 | 1.692 | BT20 BYL719 0 2 |
| BT-549 | Alpelisib | 3 | 72 | 0.032 | 3569.0 | 3936.8 | 1175.8 | -1.49 | 0.891 | 0.907 | 1.743 | BT549 BYL719 0 3 72 |
| BT-20 | Alpelisib | 2 | 72 | 0.032 | 2570.0 | 3290.8 | 1018.6 | -1.49 | 0.728 | 0.781 | 1.692 | BT20 BYL719 0 2 |
| HCC70 | Alpelisib | 1 | 72 | 0.01 | 3355.5 | 3338.5 | 1279.8 | -2.0 | 1.010 | 1.010 | 1.383 | HCC70 BYL719 0 1 72 |
| HCC70 | Alpelisib | 1 | 72 | 0.0032 | 2960.5 | 3338.5 | 1279.8 | -2.49 | 0.834 | 0.887 | 1.383 | HCC70 BYL719 0 1 72 |