Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | AZD8055 | 3 | 72 | 0.01 | 10460.5 | 11579.3 | 1273.3 | -2.0 | 0.937 | 0.903 | 3.185 | HCC1806 AZD8055 0 3 72 |
| HCC70 | AZD8055 | 3 | 72 | 0.1 | 1703.5 | 2811.8 | 517.3 | -1.0 | 0.629 | 0.606 | 2.442 | HCC70 AZD8055 0 3 72 |
| HCC70 | AZD8055 | 3 | 72 | 0.32 | 1565.0 | 2811.8 | 517.3 | -0.495 | 0.573 | 0.557 | 2.442 | HCC70 AZD8055 0 3 72 |
| BT-549 | AZD8055 | 1 | 72 | 0.001 | 5177.5 | 5342.3 | 1554.9 | -3.0 | 0.965 | 0.969 | 1.781 | BT549 AZD8055 0 1 72 |
| HCC38 | AZD8055 | 2 | 72 | 0.1 | 1413.3 | 3018.8 | 690.5 | -1.0 | 0.400 | 0.468 | 2.128 | HCC38 AZD8055 0 2 72 |
| HCC70 | AZD8055 | 3 | 72 | 0.032 | 1819.5 | 2811.8 | 517.3 | -1.49 | 0.674 | 0.647 | 2.442 | HCC70 AZD8055 0 3 72 |
| HCC38 | AZD8055 | 3 | 72 | 0.001 | 3024.8 | 3151.3 | 1180.5 | -3.0 | 0.943 | 0.960 | 1.417 | HCC38 AZD8055 0 3 72 |
| HCC70 | AZD8055 | 3 | 72 | 1.0 | 1584.0 | 2811.8 | 517.3 | 0.0 | 0.581 | 0.563 | 2.442 | HCC70 AZD8055 0 3 72 |
| HCC70 | AZD8055 | 3 | 72 | 3.2 | 1558.3 | 2811.8 | 517.3 | 0.505 | 0.571 | 0.554 | 2.442 | HCC70 AZD8055 0 3 72 |
| BT-549 | AZD8055 | 1 | 72 | 0.01 | 4136.8 | 5342.3 | 1554.9 | -2.0 | 0.732 | 0.774 | 1.781 | BT549 AZD8055 0 1 72 |
| BT-20 | AZD8055 | 1 | 72 | 0.1 | 2922.5 | 5941.5 | 1443.3 | -1.0 | 0.413 | 0.492 | 2.041 | BT20 AZD8055 0 1 |
| HCC38 | AZD8055 | 1 | 72 | 0.1 | 2302.5 | 4427.3 | 1295.5 | -1.0 | 0.383 | 0.520 | 1.773 | HCC38 AZD8055 0 1 72 |
| BT-20 | AZD8055 | 1 | 72 | 0.032 | 3968.5 | 5941.5 | 1443.3 | -1.49 | 0.641 | 0.668 | 2.041 | BT20 AZD8055 0 1 |
| BT-549 | AZD8055 | 1 | 72 | 3.2 | 2039.5 | 5342.3 | 1554.9 | 0.505 | 0.165 | 0.382 | 1.781 | BT549 AZD8055 0 1 72 |
| HCC38 | AZD8055 | 3 | 72 | 0.0032 | 2957.0 | 3151.3 | 1180.5 | -2.49 | 0.912 | 0.938 | 1.417 | HCC38 AZD8055 0 3 72 |
| HCC70 | AZD8055 | 3 | 72 | 0.01 | 2231.8 | 2811.8 | 517.3 | -2.0 | 0.819 | 0.794 | 2.442 | HCC70 AZD8055 0 3 72 |
| HCC1806 | AZD8055 | 3 | 72 | 0.032 | 9150.5 | 11579.3 | 1273.3 | -1.49 | 0.858 | 0.790 | 3.185 | HCC1806 AZD8055 0 3 72 |
| BT-549 | AZD8055 | 2 | 72 | 1.0 | 1721.3 | 4500.0 | 1249.6 | 0.0 | 0.189 | 0.383 | 1.848 | BT549 AZD8055 0 2 72 |
| BT-549 | AZD8055 | 1 | 72 | 1.0 | 2083.3 | 5342.3 | 1554.9 | 0.0 | 0.179 | 0.390 | 1.781 | BT549 AZD8055 0 1 72 |
| BT-549 | AZD8055 | 2 | 72 | 3.2 | 1591.7 | 4500.0 | 1249.6 | 0.505 | 0.140 | 0.354 | 1.848 | BT549 AZD8055 0 2 72 |
| BT-549 | AZD8055 | 2 | 72 | 0.001 | 4481.3 | 4500.0 | 1249.6 | -3.0 | 0.995 | 0.996 | 1.848 | BT549 AZD8055 0 2 72 |
| BT-549 | AZD8055 | 2 | 72 | 0.32 | 1583.8 | 4500.0 | 1249.6 | -0.495 | 0.137 | 0.352 | 1.848 | BT549 AZD8055 0 2 72 |
| HCC1806 | AZD8055 | 2 | 72 | 1.0 | 5727.5 | 11579.3 | 1643.3 | 0.0 | 0.558 | 0.495 | 2.817 | HCC1806 AZD8055 0 2 72 |
| HCC1806 | AZD8055 | 2 | 72 | 0.1 | 7212.5 | 11579.3 | 1643.3 | -1.0 | 0.691 | 0.623 | 2.817 | HCC1806 AZD8055 0 2 72 |
| HCC38 | AZD8055 | 3 | 72 | 0.1 | 1727.0 | 3151.3 | 1180.5 | -1.0 | 0.308 | 0.548 | 1.417 | HCC38 AZD8055 0 3 72 |