Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | AS605240 | 2 | 72 | 0.32 | 11293.3 | 11546.3 | 1643.3 | -0.495 | 0.984 | 0.978 | 2.813 | HCC1806 AS605240 0 2 72 |
| HCC70 | AS605240 | 2 | 72 | 0.001 | 2419.8 | 2466.3 | 722.8 | -3.0 | 0.979 | 0.981 | 1.771 | HCC70 AS605240 0 2 72 |
| HCC1806 | AS605240 | 2 | 72 | 0.0032 | 11624.3 | 11546.3 | 1643.3 | -2.49 | 1.000 | 1.010 | 2.813 | HCC1806 AS605240 0 2 72 |
| HCC1806 | AS605240 | 2 | 72 | 0.01 | 11617.5 | 11546.3 | 1643.3 | -2.0 | 1.000 | 1.010 | 2.813 | HCC1806 AS605240 0 2 72 |
| HCC1806 | AS605240 | 2 | 72 | 0.001 | 11618.8 | 11546.3 | 1643.3 | -3.0 | 1.000 | 1.010 | 2.813 | HCC1806 AS605240 0 2 72 |
| HCC70 | AS605240 | 2 | 72 | 0.032 | 2332.0 | 2466.3 | 722.8 | -1.49 | 0.938 | 0.946 | 1.771 | HCC70 AS605240 0 2 72 |
| HCC70 | AS605240 | 2 | 72 | 0.1 | 2308.5 | 2466.3 | 722.8 | -1.0 | 0.927 | 0.936 | 1.771 | HCC70 AS605240 0 2 72 |
| HCC1806 | AS605240 | 2 | 72 | 0.032 | 11947.8 | 11546.3 | 1643.3 | -1.49 | 1.020 | 1.030 | 2.813 | HCC1806 AS605240 0 2 72 |
| HCC38 | AS605240 | 2 | 72 | 0.1 | 2827.5 | 3173.5 | 690.5 | -1.0 | 0.898 | 0.891 | 2.200 | HCC38 AS605240 0 2 72 |
| BT-20 | AS605240 | 1 | 72 | 3.2 | 5187.0 | 6371.0 | 1443.3 | 0.505 | 0.817 | 0.814 | 2.142 | BT20 AS605240 0 1 |
| HCC1806 | AS605240 | 3 | 72 | 0.1 | 11678.3 | 11546.3 | 1273.3 | -1.0 | 1.010 | 1.010 | 3.181 | HCC1806 AS605240 0 3 72 |
| Hs 578T | AS605240 | 1 | 72 | 0.1 | 2796.0 | 3529.0 | 873.1 | -1.0 | 0.782 | 0.792 | 2.015 | Hs578T AS605240 1 |
| Hs 578T | AS605240 | 2 | 72 | 0.032 | 3311.5 | 3652.0 | 624.7 | -1.49 | 0.925 | 0.907 | 2.547 | Hs578T AS605240 2 |
| BT-549 | AZD-6482 | 3 | 72 | 1.0 | 3139.3 | 3938.5 | 1175.8 | 0.0 | 0.756 | 0.797 | 1.744 | BT549 AZD6482 0 3 72 |
| BT-549 | AZD-6482 | 3 | 72 | 3.2 | 2715.8 | 3938.5 | 1175.8 | 0.505 | 0.616 | 0.690 | 1.744 | BT549 AZD6482 0 3 72 |
| BT-549 | AZD-6482 | 1 | 72 | 0.001 | 5306.0 | 5406.8 | 1554.9 | -3.0 | 0.979 | 0.981 | 1.798 | BT549 AZD6482 0 1 72 |
| BT-20 | AZD-6482 | 1 | 72 | 1.0 | 3655.0 | 5948.8 | 1443.3 | 0.0 | 0.576 | 0.614 | 2.043 | BT20 AZD6482 0 1 |
| HCC38 | AZD-6482 | 2 | 72 | 3.2 | 2707.3 | 3027.0 | 690.5 | 0.505 | 0.898 | 0.894 | 2.132 | HCC38 AZD6482 0 2 72 |
| HCC38 | AZD-6482 | 2 | 72 | 0.01 | 2990.5 | 3027.0 | 690.5 | -2.0 | 0.989 | 0.988 | 2.132 | HCC38 AZD6482 0 2 72 |
| BT-549 | AZD-6482 | 1 | 72 | 0.0032 | 5209.0 | 5406.8 | 1554.9 | -2.49 | 0.959 | 0.963 | 1.798 | BT549 AZD6482 0 1 72 |
| HCC38 | AZD-6482 | 2 | 72 | 0.032 | 3000.0 | 3027.0 | 690.5 | -1.49 | 0.992 | 0.991 | 2.132 | HCC38 AZD6482 0 2 72 |
| HCC38 | AZD-6482 | 2 | 72 | 0.0032 | 2939.3 | 3027.0 | 690.5 | -2.49 | 0.973 | 0.971 | 2.132 | HCC38 AZD6482 0 2 72 |
| HCC38 | AZD-6482 | 2 | 72 | 0.1 | 3010.8 | 3027.0 | 690.5 | -1.0 | 0.995 | 0.995 | 2.132 | HCC38 AZD6482 0 2 72 |
| BT-549 | AZD-6482 | 3 | 72 | 0.1 | 3789.3 | 3938.5 | 1175.8 | -1.0 | 0.956 | 0.962 | 1.744 | BT549 AZD6482 0 3 72 |
| HCC38 | AZD-6482 | 1 | 72 | 0.001 | 4232.0 | 4304.5 | 1295.5 | -3.0 | 0.980 | 0.983 | 1.732 | HCC38 AZD6482 0 1 72 |