Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | AS605240 | 1 | 72 | 0.01 | 4351.3 | 4340.3 | 1295.5 | -2.0 | 1.000 | 1.000 | 1.744 | HCC38 AS605240 0 1 72 |
| HCC1806 | AS605240 | 1 | 72 | 0.32 | 11293.3 | 11546.3 | 1742.8 | -0.495 | 0.984 | 0.978 | 2.728 | HCC1806 AS605240 0 1 72 |
| HCC1806 | AS605240 | 1 | 72 | 3.2 | 10191.5 | 11546.3 | 1742.8 | 0.505 | 0.911 | 0.883 | 2.728 | HCC1806 AS605240 0 1 72 |
| HCC1806 | AS605240 | 1 | 72 | 0.032 | 11947.8 | 11546.3 | 1742.8 | -1.49 | 1.030 | 1.030 | 2.728 | HCC1806 AS605240 0 1 72 |
| HCC1806 | AS605240 | 1 | 72 | 0.1 | 11678.3 | 11546.3 | 1742.8 | -1.0 | 1.010 | 1.010 | 2.728 | HCC1806 AS605240 0 1 72 |
| HCC70 | AS605240 | 1 | 72 | 0.1 | 3016.3 | 3347.8 | 1279.8 | -1.0 | 0.855 | 0.901 | 1.387 | HCC70 AS605240 0 1 72 |
| HCC38 | AS605240 | 3 | 72 | 1.0 | 2963.5 | 2994.3 | 1180.5 | 0.0 | 0.985 | 0.990 | 1.343 | HCC38 AS605240 0 3 72 |
| BT-20 | AS605240 | 3 | 72 | 3.2 | 2896.3 | 3575.0 | 586.9 | 0.505 | 0.845 | 0.810 | 2.607 | BT20 AS605240 0 3 |
| BT-549 | AS605240 | 3 | 72 | 0.0032 | 3907.5 | 4082.5 | 1175.8 | -2.49 | 0.952 | 0.957 | 1.796 | BT549 AS605240 0 3 72 |
| HCC1806 | AS605240 | 1 | 72 | 0.001 | 11618.8 | 11546.3 | 1742.8 | -3.0 | 1.000 | 1.010 | 2.728 | HCC1806 AS605240 0 1 72 |
| HCC38 | AS605240 | 3 | 72 | 0.1 | 3083.5 | 2994.3 | 1180.5 | -1.0 | 1.040 | 1.030 | 1.343 | HCC38 AS605240 0 3 72 |
| HCC38 | AS605240 | 3 | 72 | 0.32 | 3034.0 | 2994.3 | 1180.5 | -0.495 | 1.020 | 1.010 | 1.343 | HCC38 AS605240 0 3 72 |
| HCC38 | AS605240 | 3 | 72 | 3.2 | 2910.0 | 2994.3 | 1180.5 | 0.505 | 0.958 | 0.972 | 1.343 | HCC38 AS605240 0 3 72 |
| BT-549 | AS605240 | 3 | 72 | 0.032 | 3855.5 | 4082.5 | 1175.8 | -1.49 | 0.937 | 0.944 | 1.796 | BT549 AS605240 0 3 72 |
| HCC1806 | AS605240 | 1 | 72 | 0.0032 | 11624.3 | 11546.3 | 1742.8 | -2.49 | 1.000 | 1.010 | 2.728 | HCC1806 AS605240 0 1 72 |
| HCC38 | AS605240 | 2 | 72 | 1.0 | 2465.5 | 3173.5 | 690.5 | 0.0 | 0.783 | 0.777 | 2.200 | HCC38 AS605240 0 2 72 |
| BT-20 | AS605240 | 1 | 72 | 0.1 | 5634.5 | 6371.0 | 1443.3 | -1.0 | 0.889 | 0.884 | 2.142 | BT20 AS605240 0 1 |
| HCC1806 | AS605240 | 1 | 72 | 0.01 | 11617.5 | 11546.3 | 1742.8 | -2.0 | 1.000 | 1.010 | 2.728 | HCC1806 AS605240 0 1 72 |
| HCC38 | AS605240 | 3 | 72 | 0.001 | 3065.8 | 2994.3 | 1180.5 | -3.0 | 1.040 | 1.020 | 1.343 | HCC38 AS605240 0 3 72 |
| BT-20 | AS605240 | 3 | 72 | 0.0032 | 3254.5 | 3575.0 | 586.9 | -2.49 | 0.929 | 0.910 | 2.607 | BT20 AS605240 0 3 |
| HCC38 | AS605240 | 3 | 72 | 0.0032 | 2991.0 | 2994.3 | 1180.5 | -2.49 | 0.998 | 0.999 | 1.343 | HCC38 AS605240 0 3 72 |
| HCC70 | AS605240 | 3 | 72 | 0.1 | 2523.0 | 2821.5 | 517.3 | -1.0 | 0.911 | 0.894 | 2.447 | HCC70 AS605240 0 3 72 |
| BT-20 | AS605240 | 3 | 72 | 0.01 | 3575.3 | 3575.0 | 586.9 | -2.0 | 1.000 | 1.000 | 2.607 | BT20 AS605240 0 3 |
| BT-549 | AS605240 | 1 | 72 | 3.2 | 4915.0 | 5429.5 | 1554.9 | 0.505 | 0.893 | 0.905 | 1.804 | BT549 AS605240 0 1 72 |
| HCC70 | AS605240 | 3 | 72 | 0.32 | 2196.8 | 2821.5 | 517.3 | -0.495 | 0.806 | 0.779 | 2.447 | HCC70 AS605240 0 3 72 |