Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | Torin2 | 3 | 72 | 0.32 | 1227.5 | 11795.0 | 1273.3 | -0.495 | -0.011 | 0.104 | 3.212 | HCC1806 Torin2 0 3 72 |
| HCC1806 | Torin2 | 1 | 72 | 0.32 | 1227.5 | 11795.0 | 1742.8 | -0.495 | -0.119 | 0.104 | 2.759 | HCC1806 Torin2 0 1 72 |
| HCC1806 | Torin2 | 2 | 72 | 0.32 | 1227.5 | 11795.0 | 1643.3 | -0.495 | -0.098 | 0.104 | 2.843 | HCC1806 Torin2 0 2 72 |
| BT-20 | Buparlisib | 2 | 72 | 3.2 | 359.5 | 3408.8 | 1018.6 | 0.505 | -0.450 | 0.105 | 1.743 | BT20 BKM120 0 2 |
| HCC70 | Omipalisib | 1 | 72 | 0.32 | 383.8 | 3280.0 | 1279.8 | -0.495 | -0.588 | 0.117 | 1.358 | HCC70 GSK458 0 1 72 |
| HCC1806 | Dactolisib | 2 | 72 | 3.2 | 1409.8 | 11670.0 | 1643.3 | 0.505 | -0.053 | 0.121 | 2.828 | HCC1806 BEZ235 0 2 72 |
| HCC1806 | Dactolisib | 3 | 72 | 3.2 | 1409.8 | 11670.0 | 1273.3 | 0.505 | 0.032 | 0.121 | 3.196 | HCC1806 BEZ235 0 3 72 |
| HCC1806 | Dactolisib | 1 | 72 | 3.2 | 1409.8 | 11670.0 | 1742.8 | 0.505 | -0.074 | 0.121 | 2.743 | HCC1806 BEZ235 0 1 72 |
| HCC70 | Omipalisib | 2 | 72 | 0.32 | 281.3 | 2319.3 | 722.8 | -0.495 | -0.429 | 0.121 | 1.682 | HCC70 GSK458 0 2 72 |
| HCC70 | Buparlisib | 3 | 72 | 3.2 | 341.8 | 2804.3 | 517.3 | 0.505 | -0.156 | 0.122 | 2.439 | HCC70 BKM120 0 3 72 |
| BT-20 | AZD8055 | 2 | 72 | 3.2 | 419.0 | 3421.5 | 1018.6 | 0.505 | -0.398 | 0.122 | 1.748 | BT20 AZD8055 0 2 |
| HCC38 | BX-912 | 2 | 72 | 3.2 | 390.8 | 3142.0 | 690.5 | 0.505 | -0.229 | 0.124 | 2.186 | HCC38 BX912 0 2 72 |
| BT-20 | GDC-0980 | 1 | 72 | 3.2 | 730.3 | 5778.5 | 1443.3 | 0.505 | -0.289 | 0.126 | 2.001 | BT20 GDC0980 0 1 |
| Hs 578T | Omipalisib | 1 | 72 | 1.0 | 465.3 | 3689.5 | 873.1 | 0.0 | -0.261 | 0.126 | 2.079 | Hs578T GSK458 1 |
| BT-549 | Omipalisib | 2 | 72 | 3.2 | 630.0 | 4963.8 | 1249.6 | 0.505 | -0.291 | 0.127 | 1.990 | BT549 GSK458 0 2 72 |
| HCC70 | Torin2 | 3 | 72 | 1.0 | 358.5 | 2778.8 | 517.3 | 0.0 | -0.140 | 0.129 | 2.425 | HCC70 Torin2 0 3 72 |
| BT-20 | GDC-0980 | 3 | 72 | 3.2 | 432.8 | 3324.8 | 586.9 | 0.505 | -0.115 | 0.130 | 2.502 | BT20 GDC0980 0 3 |
| BT-20 | GDC-0980 | 2 | 72 | 3.2 | 420.0 | 3217.8 | 1018.6 | 0.505 | -0.414 | 0.131 | 1.659 | BT20 GDC0980 0 2 |
| Hs 578T | Torin2 | 1 | 72 | 1.0 | 467.0 | 3568.0 | 873.1 | 0.0 | -0.265 | 0.131 | 2.031 | Hs578T Torin2 1 |
| BT-549 | Buparlisib | 3 | 72 | 3.2 | 540.8 | 4081.3 | 1175.8 | 0.505 | -0.351 | 0.132 | 1.795 | BT549 BKM120 0 3 72 |
| BT-549 | Buparlisib | 2 | 72 | 3.2 | 621.8 | 4705.0 | 1249.6 | 0.505 | -0.306 | 0.132 | 1.913 | BT549 BKM120 0 2 72 |
| HCC70 | Omipalisib | 3 | 72 | 0.32 | 379.8 | 2841.5 | 517.3 | -0.495 | -0.118 | 0.134 | 2.458 | HCC70 GSK458 0 3 72 |
| BT-20 | Omipalisib | 3 | 72 | 0.32 | 473.0 | 3523.0 | 586.9 | -0.495 | -0.080 | 0.134 | 2.586 | BT20 GSK458 0 3 |
| HCC38 | Omipalisib | 3 | 72 | 3.2 | 429.5 | 3215.3 | 1180.5 | 0.505 | -0.503 | 0.134 | 1.446 | HCC38 GSK458 0 3 72 |
| BT-20 | Omipalisib | 1 | 72 | 0.32 | 819.0 | 6095.3 | 1443.3 | -0.495 | -0.239 | 0.134 | 2.078 | BT20 GSK458 0 1 |