Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | Torin2 | 3 | 72 | 3.2 | 160.0 | 2778.8 | 517.3 | 0.505 | -0.384 | 0.058 | 2.425 | HCC70 Torin2 0 3 72 |
| Hs 578T | Torin2 | 2 | 72 | 1.0 | 212.3 | 3604.3 | 624.7 | 0.0 | -0.347 | 0.059 | 2.528 | Hs578T Torin2 2 |
| HCC38 | Omipalisib | 2 | 72 | 3.2 | 179.0 | 3009.3 | 690.5 | 0.505 | -0.470 | 0.060 | 2.124 | HCC38 GSK458 0 2 72 |
| HCC70 | Torin2 | 1 | 72 | 3.2 | 212.0 | 3294.3 | 1279.8 | 0.505 | -0.732 | 0.064 | 1.364 | HCC70 Torin2 0 1 72 |
| HCC70 | Omipalisib | 2 | 72 | 1.0 | 158.0 | 2319.3 | 722.8 | 0.0 | -0.595 | 0.068 | 1.682 | HCC70 GSK458 0 2 72 |
| BT-20 | Omipalisib | 2 | 72 | 1.0 | 235.0 | 3349.0 | 1018.6 | 0.0 | -0.574 | 0.070 | 1.717 | BT20 GSK458 0 2 |
| BT-20 | Buparlisib | 3 | 72 | 3.2 | 235.8 | 3388.3 | 586.9 | 0.505 | -0.303 | 0.070 | 2.529 | BT20 BKM120 0 3 |
| HCC70 | Torin2 | 2 | 72 | 3.2 | 187.8 | 2562.3 | 722.8 | 0.505 | -0.522 | 0.073 | 1.826 | HCC70 Torin2 0 2 72 |
| Hs 578T | Omipalisib | 2 | 72 | 1.0 | 258.0 | 3550.3 | 624.7 | 0.0 | -0.297 | 0.073 | 2.507 | Hs578T GSK458 2 |
| HCC70 | Omipalisib | 1 | 72 | 1.0 | 253.0 | 3280.0 | 1279.8 | 0.0 | -0.697 | 0.077 | 1.358 | HCC70 GSK458 0 1 72 |
| BT-20 | Buparlisib | 1 | 72 | 3.2 | 495.8 | 6321.8 | 1443.3 | 0.505 | -0.394 | 0.078 | 2.131 | BT20 BKM120 0 1 |
| BT-20 | Torin2 | 1 | 72 | 1.0 | 457.3 | 5846.0 | 1443.3 | 0.0 | -0.434 | 0.078 | 2.018 | BT20 Torin2 0 1 |
| HCC1806 | Torin2 | 1 | 72 | 3.2 | 931.5 | 11795.0 | 1742.8 | 0.505 | -0.203 | 0.079 | 2.759 | HCC1806 Torin2 0 1 72 |
| HCC1806 | Torin2 | 2 | 72 | 3.2 | 931.5 | 11795.0 | 1643.3 | 0.505 | -0.181 | 0.079 | 2.843 | HCC1806 Torin2 0 2 72 |
| HCC1806 | Torin2 | 3 | 72 | 3.2 | 931.5 | 11795.0 | 1273.3 | 0.505 | -0.093 | 0.079 | 3.212 | HCC1806 Torin2 0 3 72 |
| HCC70 | Omipalisib | 3 | 72 | 1.0 | 228.8 | 2841.5 | 517.3 | 0.0 | -0.283 | 0.081 | 2.458 | HCC70 GSK458 0 3 72 |
| Hs 578T | Torin2 | 3 | 72 | 1.0 | 337.8 | 4103.3 | 571.3 | 0.0 | -0.169 | 0.082 | 2.844 | Hs578T Torin2 3 |
| HCC1806 | Torin2 | 2 | 72 | 1.0 | 999.5 | 11795.0 | 1643.3 | 0.0 | -0.160 | 0.085 | 2.843 | HCC1806 Torin2 0 2 72 |
| Hs 578T | Torin2 | 1 | 72 | 3.2 | 303.8 | 3568.0 | 873.1 | 0.505 | -0.405 | 0.085 | 2.031 | Hs578T Torin2 1 |
| HCC1806 | Torin2 | 3 | 72 | 1.0 | 999.5 | 11795.0 | 1273.3 | 0.0 | -0.073 | 0.085 | 3.212 | HCC1806 Torin2 0 3 72 |
| HCC1806 | Torin2 | 1 | 72 | 1.0 | 999.5 | 11795.0 | 1742.8 | 0.0 | -0.183 | 0.085 | 2.759 | HCC1806 Torin2 0 1 72 |
| BT-20 | Torin2 | 3 | 72 | 1.0 | 307.3 | 3225.3 | 586.9 | 0.0 | -0.231 | 0.095 | 2.458 | BT20 Torin2 0 3 |
| HCC38 | Torin2 | 2 | 72 | 1.0 | 295.3 | 3044.5 | 690.5 | 0.0 | -0.328 | 0.097 | 2.140 | HCC38 Torin2 0 2 72 |
| Hs 578T | Omipalisib | 3 | 72 | 3.2 | 412.8 | 4175.0 | 571.3 | 0.505 | -0.107 | 0.099 | 2.869 | Hs578T GSK458 3 |
| HCC38 | Torin2 | 3 | 72 | 3.2 | 304.0 | 3083.5 | 1180.5 | 0.505 | -0.624 | 0.099 | 1.385 | HCC38 Torin2 0 3 72 |