Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | AS605240 | 2 | 72 | 0.0032 | 3249.3 | 3173.5 | 690.5 | -2.49 | 1.020 | 1.020 | 2.200 | HCC38 AS605240 0 2 72 |
| Hs 578T | PIK-93 | 2 | 72 | 0.001 | 3518.8 | 3455.0 | 624.7 | -3.0 | 1.010 | 1.020 | 2.467 | Hs578T PIK93 2 |
| Hs 578T | PIK-93 | 2 | 72 | 0.032 | 3509.5 | 3455.0 | 624.7 | -1.49 | 1.010 | 1.020 | 2.467 | Hs578T PIK93 2 |
| HCC1806 | TGX221 | 1 | 72 | 0.032 | 11433.8 | 11158.5 | 1742.8 | -1.49 | 1.020 | 1.020 | 2.679 | HCC1806 TGX221 0 1 72 |
| BT-20 | GDC-0980 | 3 | 72 | 0.001 | 3400.5 | 3324.8 | 586.9 | -3.0 | 1.020 | 1.020 | 2.502 | BT20 GDC0980 0 3 |
| HCC70 | Dactolisib | 2 | 72 | 0.001 | 2350.5 | 2310.8 | 722.8 | -3.0 | 1.020 | 1.020 | 1.677 | HCC70 BEZ235 0 2 72 |
| Hs 578T | TGX221 | 2 | 72 | 0.01 | 3496.5 | 3441.3 | 624.7 | -2.0 | 1.010 | 1.020 | 2.462 | Hs578T TGX221 2 |
| Hs 578T | TGX221 | 2 | 72 | 0.032 | 3499.3 | 3441.3 | 624.7 | -1.49 | 1.010 | 1.020 | 2.462 | Hs578T TGX221 2 |
| HCC1806 | KIN001-244 | 1 | 72 | 0.001 | 11912.3 | 11660.3 | 1742.8 | -3.0 | 1.020 | 1.020 | 2.742 | HCC1806 KIN001-244 0 1 72 |
| HCC38 | CAL-101 | 2 | 72 | 0.032 | 3149.8 | 3073.0 | 690.5 | -1.49 | 1.020 | 1.020 | 2.154 | HCC38 CAL101 0 2 72 |
| HCC1806 | GDC-0980 | 1 | 72 | 0.001 | 11516.0 | 11293.0 | 1742.8 | -3.0 | 1.010 | 1.020 | 2.696 | HCC1806 GDC0980 0 1 72 |
| HCC1806 | AZD-6482 | 1 | 72 | 3.2 | 11967.3 | 11709.8 | 1742.8 | 0.505 | 1.020 | 1.020 | 2.748 | HCC1806 AZD6482 0 1 72 |
| HCC1806 | AZD-6482 | 1 | 72 | 0.032 | 11940.3 | 11709.8 | 1742.8 | -1.49 | 1.010 | 1.020 | 2.748 | HCC1806 AZD6482 0 1 72 |
| Hs 578T | XL147 | 2 | 72 | 0.01 | 3614.3 | 3556.8 | 624.7 | -2.0 | 1.010 | 1.020 | 2.509 | Hs578T XL147 2 |
| Hs 578T | XL147 | 2 | 72 | 0.32 | 3631.0 | 3556.8 | 624.7 | -0.495 | 1.020 | 1.020 | 2.509 | Hs578T XL147 2 |
| HCC70 | ZSTK474 | 3 | 72 | 0.001 | 2995.3 | 2931.3 | 517.3 | -3.0 | 1.020 | 1.020 | 2.502 | HCC70 ZSTK474 0 3 72 |
| Hs 578T | AS605240 | 3 | 72 | 0.001 | 4217.0 | 4137.8 | 571.3 | -3.0 | 1.010 | 1.020 | 2.856 | Hs578T AS605240 3 |
| HCC38 | AS605240 | 3 | 72 | 0.001 | 3065.8 | 2994.3 | 1180.5 | -3.0 | 1.040 | 1.020 | 1.343 | HCC38 AS605240 0 3 72 |
| HCC38 | AS605240 | 3 | 72 | 0.01 | 3058.0 | 2994.3 | 1180.5 | -2.0 | 1.030 | 1.020 | 1.343 | HCC38 AS605240 0 3 72 |
| Hs 578T | AZD-6482 | 3 | 72 | 0.0032 | 4163.3 | 4067.8 | 571.3 | -2.49 | 1.020 | 1.020 | 2.832 | Hs578T AZD6482 3 |
| Hs 578T | AZD-6482 | 3 | 72 | 0.032 | 4133.5 | 4067.8 | 571.3 | -1.49 | 1.010 | 1.020 | 2.832 | Hs578T AZD6482 3 |
| HCC38 | AZD-6482 | 3 | 72 | 0.001 | 3207.3 | 3159.3 | 1180.5 | -3.0 | 1.020 | 1.020 | 1.420 | HCC38 AZD6482 0 3 72 |
| HCC70 | Torin1 | 3 | 72 | 0.001 | 2800.3 | 2758.5 | 517.3 | -3.0 | 1.010 | 1.020 | 2.415 | HCC70 Torin1 0 3 72 |
| HCC70 | PI103 | 3 | 72 | 0.0032 | 2870.3 | 2818.5 | 517.3 | -2.49 | 1.010 | 1.020 | 2.446 | HCC70 PI103 0 3 72 |
| HCC70 | KIN001-244 | 3 | 72 | 0.1 | 2917.3 | 2870.0 | 517.3 | -1.0 | 1.010 | 1.020 | 2.472 | HCC70 KIN001-244 0 3 72 |