Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | Torin2 | 2 | 72 | 0.032 | 911.5 | 3386.5 | 1018.6 | -1.49 | -0.062 | 0.269 | 1.733 | BT20 Torin2 0 2 |
| HCC70 | GDC-0980 | 2 | 72 | 3.2 | 623.0 | 2310.0 | 722.8 | 0.505 | -0.085 | 0.270 | 1.676 | HCC70 GDC0980 0 2 72 |
| HCC38 | Omipalisib | 2 | 72 | 0.32 | 814.8 | 3009.3 | 690.5 | -0.495 | 0.081 | 0.271 | 2.124 | HCC38 GSK458 0 2 72 |
| BT-549 | Omipalisib | 3 | 72 | 0.32 | 1093.3 | 4029.3 | 1175.8 | -0.495 | -0.040 | 0.271 | 1.777 | BT549 GSK458 0 3 72 |
| BT-20 | Pictilisib | 2 | 72 | 3.2 | 927.8 | 3416.0 | 1018.6 | 0.505 | -0.052 | 0.272 | 1.746 | BT20 GDC0941 0 2 |
| HCC1806 | Torin1 | 1 | 72 | 3.2 | 3197.0 | 11764.8 | 1742.8 | 0.505 | 0.246 | 0.272 | 2.755 | HCC1806 Torin1 0 1 72 |
| BT-20 | AZD8055 | 2 | 72 | 0.1 | 929.8 | 3421.5 | 1018.6 | -1.0 | -0.051 | 0.272 | 1.748 | BT20 AZD8055 0 2 |
| BT-20 | ZSTK474 | 1 | 72 | 3.2 | 1504.8 | 5537.8 | 1443.3 | 0.505 | 0.022 | 0.272 | 1.940 | BT20 ZSTK474 0 1 |
| HCC1806 | Torin1 | 2 | 72 | 3.2 | 3197.0 | 11764.8 | 1643.3 | 0.505 | 0.264 | 0.272 | 2.840 | HCC1806 Torin1 0 2 72 |
| BT-20 | Alpelisib | 3 | 72 | 3.2 | 930.3 | 3415.3 | 586.9 | 0.505 | 0.199 | 0.272 | 2.541 | BT20 BYL719 0 3 |
| HCC1806 | Torin1 | 3 | 72 | 3.2 | 3197.0 | 11764.8 | 1273.3 | 0.505 | 0.332 | 0.272 | 3.208 | HCC1806 Torin1 0 3 72 |
| BT-20 | WYE-125132 | 3 | 72 | 0.32 | 917.3 | 3344.0 | 586.9 | -0.495 | 0.195 | 0.274 | 2.510 | BT20 WYE125132 0 3 |
| BT-20 | ZSTK474 | 3 | 72 | 1.0 | 982.5 | 3579.5 | 586.9 | 0.0 | 0.218 | 0.274 | 2.609 | BT20 ZSTK474 0 3 |
| BT-549 | GDC-0980 | 2 | 72 | 3.2 | 1314.3 | 4792.0 | 1249.6 | 0.505 | 0.026 | 0.274 | 1.939 | BT549 GDC0980 0 2 72 |
| BT-549 | Dactolisib | 1 | 72 | 3.2 | 1533.0 | 5568.8 | 1554.9 | 0.505 | -0.008 | 0.275 | 1.840 | BT549 BEZ235 0 1 72 |
| Hs 578T | Torin1 | 1 | 72 | 1.0 | 935.0 | 3386.5 | 873.1 | 0.0 | 0.036 | 0.276 | 1.956 | Hs578T Torin1 1 |
| Hs 578T | WYE-125132 | 2 | 72 | 0.32 | 1007.0 | 3642.3 | 624.7 | -0.495 | 0.206 | 0.276 | 2.544 | Hs578T WYE125132 2 |
| BT-20 | PI103 | 2 | 72 | 1.0 | 929.3 | 3367.0 | 1018.6 | 0.0 | -0.052 | 0.276 | 1.725 | BT20 PI103 0 2 |
| Hs 578T | WYE-125132 | 3 | 72 | 0.32 | 1162.5 | 4195.3 | 571.3 | -0.495 | 0.280 | 0.277 | 2.876 | Hs578T WYE125132 3 |
| HCC38 | Torin2 | 2 | 72 | 0.1 | 847.0 | 3044.5 | 690.5 | -1.0 | 0.100 | 0.278 | 2.140 | HCC38 Torin2 0 2 72 |
| Hs 578T | WYE-125132 | 1 | 72 | 1.0 | 982.0 | 3529.8 | 873.1 | 0.0 | 0.060 | 0.278 | 2.015 | Hs578T WYE125132 1 |
| BT-549 | Torin2 | 2 | 72 | 0.32 | 1231.8 | 4425.3 | 1249.6 | -0.495 | -0.008 | 0.278 | 1.824 | BT549 Torin2 0 2 72 |
| BT-549 | PI103 | 2 | 72 | 3.2 | 1297.5 | 4640.0 | 1249.6 | 0.505 | 0.020 | 0.280 | 1.893 | BT549 PI103 0 2 72 |
| HCC70 | ZSTK474 | 2 | 72 | 3.2 | 673.8 | 2409.0 | 722.8 | 0.505 | -0.040 | 0.280 | 1.737 | HCC70 ZSTK474 0 2 72 |
| Hs 578T | GDC-0980 | 3 | 72 | 1.0 | 1138.5 | 4064.8 | 571.3 | 0.0 | 0.276 | 0.280 | 2.831 | Hs578T GDC0980 3 |