Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | Torin2 | 3 | 72 | 0.32 | 791.8 | 3083.5 | 1180.5 | -0.495 | -0.251 | 0.257 | 1.385 | HCC38 Torin2 0 3 72 |
| BT-20 | PI103 | 1 | 72 | 3.2 | 1411.8 | 5476.0 | 1443.3 | 0.505 | -0.011 | 0.258 | 1.924 | BT20 PI103 0 1 |
| Hs 578T | AZD8055 | 3 | 72 | 3.2 | 1096.0 | 4224.8 | 571.3 | 0.505 | 0.253 | 0.259 | 2.886 | Hs578T AZD8055 3 |
| BT-20 | Alpelisib | 2 | 72 | 3.2 | 853.3 | 3290.8 | 1018.6 | 0.505 | -0.099 | 0.259 | 1.692 | BT20 BYL719 0 2 |
| HCC38 | Torin2 | 1 | 72 | 0.32 | 1150.3 | 4443.3 | 1295.5 | -0.495 | -0.065 | 0.259 | 1.778 | HCC38 Torin2 0 1 72 |
| BT-20 | Alpelisib | 1 | 72 | 3.2 | 1584.5 | 6091.5 | 1443.3 | 0.505 | 0.046 | 0.260 | 2.077 | BT20 BYL719 0 1 |
| HCC1806 | Buparlisib | 2 | 72 | 1.0 | 3030.5 | 11660.8 | 1643.3 | 0.0 | 0.242 | 0.260 | 2.827 | HCC1806 BKM120 0 2 72 |
| Hs 578T | PI103 | 2 | 72 | 1.0 | 919.5 | 3540.3 | 624.7 | 0.0 | 0.167 | 0.260 | 2.503 | Hs578T PI103 2 |
| Hs 578T | Torin2 | 2 | 72 | 0.1 | 937.8 | 3604.3 | 624.7 | -1.0 | 0.174 | 0.260 | 2.528 | Hs578T Torin2 2 |
| HCC1806 | Buparlisib | 3 | 72 | 1.0 | 3030.5 | 11660.8 | 1273.3 | 0.0 | 0.312 | 0.260 | 3.195 | HCC1806 BKM120 0 3 72 |
| HCC1806 | Buparlisib | 1 | 72 | 1.0 | 3030.5 | 11660.8 | 1742.8 | 0.0 | 0.224 | 0.260 | 2.742 | HCC1806 BKM120 0 1 72 |
| Hs 578T | Torin2 | 3 | 72 | 0.1 | 1072.5 | 4103.3 | 571.3 | -1.0 | 0.248 | 0.261 | 2.844 | Hs578T Torin2 3 |
| HCC38 | Dactolisib | 3 | 72 | 3.2 | 855.8 | 3265.3 | 1180.5 | 0.505 | -0.197 | 0.262 | 1.468 | HCC38 BEZ235 0 3 72 |
| HCC38 | Dactolisib | 1 | 72 | 3.2 | 1202.0 | 4578.0 | 1295.5 | 0.505 | -0.040 | 0.263 | 1.821 | HCC38 BEZ235 0 1 72 |
| Hs 578T | AZD8055 | 3 | 72 | 0.32 | 1113.3 | 4224.8 | 571.3 | -0.495 | 0.260 | 0.264 | 2.886 | Hs578T AZD8055 3 |
| Hs 578T | ZSTK474 | 2 | 72 | 3.2 | 968.8 | 3668.0 | 624.7 | 0.505 | 0.187 | 0.264 | 2.554 | Hs578T ZSTK474 2 |
| BT-20 | GDC-0980 | 1 | 72 | 0.32 | 1527.5 | 5778.5 | 1443.3 | -0.495 | 0.029 | 0.264 | 2.001 | BT20 GDC0980 0 1 |
| HCC70 | ZSTK474 | 1 | 72 | 3.2 | 849.3 | 3221.8 | 1279.8 | 0.505 | -0.265 | 0.264 | 1.332 | HCC70 ZSTK474 0 1 72 |
| BT-20 | Dactolisib | 3 | 72 | 0.32 | 833.5 | 3141.3 | 586.9 | -0.495 | 0.156 | 0.265 | 2.420 | BT20 BEZ235 0 3 |
| HCC70 | ZSTK474 | 3 | 72 | 3.2 | 776.5 | 2931.3 | 517.3 | 0.505 | 0.176 | 0.265 | 2.502 | HCC70 ZSTK474 0 3 72 |
| BT-549 | Dactolisib | 2 | 72 | 3.2 | 1229.3 | 4628.8 | 1249.6 | 0.505 | -0.009 | 0.266 | 1.889 | BT549 BEZ235 0 2 72 |
| HCC38 | Torin1 | 3 | 72 | 3.2 | 853.0 | 3204.3 | 1180.5 | 0.505 | -0.202 | 0.266 | 1.441 | HCC38 Torin1 0 3 72 |
| Hs 578T | Torin1 | 1 | 72 | 3.2 | 904.5 | 3386.5 | 873.1 | 0.505 | 0.018 | 0.267 | 1.956 | Hs578T Torin1 1 |
| Hs 578T | Trametinib | 2 | 72 | 0.1 | 935.8 | 3491.8 | 624.7 | -1.0 | 0.177 | 0.268 | 2.483 | Hs578T Trametinib 2 |
| HCC70 | BX-912 | 3 | 72 | 3.2 | 767.5 | 2856.5 | 517.3 | 0.505 | 0.174 | 0.269 | 2.465 | HCC70 BX912 0 3 72 |