Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TGX221 | 2 | 72 | 0.001 | 3441.5 | 3441.3 | 624.7 | -3.0 | 1.000 | 1.000 | 2.462 | Hs578T TGX221 2 |
| Hs 578T | Torin1 | 2 | 72 | 0.001 | 3381.5 | 3653.5 | 624.7 | -3.0 | 0.940 | 0.926 | 2.548 | Hs578T Torin1 2 |
| Hs 578T | Torin2 | 2 | 72 | 0.001 | 3230.5 | 3604.3 | 624.7 | -3.0 | 0.915 | 0.896 | 2.528 | Hs578T Torin2 2 |
| Hs 578T | Trametinib | 2 | 72 | 0.001 | 2454.8 | 3491.8 | 624.7 | -3.0 | 0.735 | 0.703 | 2.483 | Hs578T Trametinib 2 |
| Hs 578T | WYE-125132 | 2 | 72 | 0.001 | 3450.3 | 3642.3 | 624.7 | -3.0 | 0.958 | 0.947 | 2.544 | Hs578T WYE125132 2 |
| Hs 578T | XL147 | 2 | 72 | 0.001 | 3450.8 | 3556.8 | 624.7 | -3.0 | 0.976 | 0.970 | 2.509 | Hs578T XL147 2 |
| Hs 578T | ZSTK474 | 2 | 72 | 0.001 | 3461.3 | 3668.0 | 624.7 | -3.0 | 0.955 | 0.944 | 2.554 | Hs578T ZSTK474 2 |
| Hs 578T | AS605240 | 3 | 72 | 0.001 | 4217.0 | 4137.8 | 571.3 | -3.0 | 1.010 | 1.020 | 2.856 | Hs578T AS605240 3 |
| Hs 578T | AZD-6482 | 3 | 72 | 0.001 | 4052.5 | 4067.8 | 571.3 | -3.0 | 0.997 | 0.996 | 2.832 | Hs578T AZD6482 3 |
| Hs 578T | AZD8055 | 3 | 72 | 0.001 | 3907.0 | 4224.8 | 571.3 | -3.0 | 0.947 | 0.925 | 2.886 | Hs578T AZD8055 3 |
| Hs 578T | Dactolisib | 3 | 72 | 0.001 | 3761.0 | 4081.0 | 571.3 | -3.0 | 0.943 | 0.922 | 2.837 | Hs578T BEZ235 3 |
| Hs 578T | Buparlisib | 3 | 72 | 0.001 | 4118.3 | 4235.0 | 571.3 | -3.0 | 0.981 | 0.972 | 2.890 | Hs578T BKM120 3 |
| Hs 578T | BX-912 | 3 | 72 | 0.001 | 4175.8 | 3993.8 | 571.3 | -3.0 | 1.030 | 1.050 | 2.805 | Hs578T BX912 3 |
| Hs 578T | Alpelisib | 3 | 72 | 0.001 | 4208.5 | 4137.8 | 571.3 | -3.0 | 1.010 | 1.020 | 2.856 | Hs578T BYL719 3 |
| Hs 578T | CAL-101 | 3 | 72 | 0.001 | 4189.5 | 4189.5 | 571.3 | -3.0 | 1.000 | 1.000 | 2.874 | Hs578T CAL101 3 |
| Hs 578T | Everolimus | 3 | 72 | 0.001 | 2787.3 | 4114.8 | 571.3 | -3.0 | 0.744 | 0.677 | 2.848 | Hs578T Everolimus 3 |
| Hs 578T | Pictilisib | 3 | 72 | 0.001 | 4322.0 | 4297.8 | 571.3 | -3.0 | 1.000 | 1.010 | 2.911 | Hs578T GDC0941 3 |
| Hs 578T | GDC-0980 | 3 | 72 | 0.001 | 4093.0 | 4064.8 | 571.3 | -3.0 | 1.000 | 1.010 | 2.831 | Hs578T GDC0980 3 |
| Hs 578T | Omipalisib | 3 | 72 | 0.001 | 3564.8 | 4175.0 | 571.3 | -3.0 | 0.893 | 0.854 | 2.869 | Hs578T GSK458 3 |
| Hs 578T | KIN001-244 | 3 | 72 | 0.001 | 4053.8 | 4230.0 | 571.3 | -3.0 | 0.971 | 0.958 | 2.888 | Hs578T KIN001-244 3 |
| Hs 578T | MK2206 | 3 | 72 | 0.001 | 4169.3 | 4213.3 | 571.3 | -3.0 | 0.993 | 0.990 | 2.883 | Hs578T MK2206 3 |
| Hs 578T | PI103 | 3 | 72 | 0.001 | 4138.5 | 3999.0 | 571.3 | -3.0 | 1.020 | 1.030 | 2.807 | Hs578T PI103 3 |
| Hs 578T | PIK-93 | 3 | 72 | 0.001 | 4137.8 | 4023.5 | 571.3 | -3.0 | 1.020 | 1.030 | 2.816 | Hs578T PIK93 3 |
| Hs 578T | Sirolimus | 3 | 72 | 0.001 | 2611.5 | 4078.5 | 571.3 | -3.0 | 0.709 | 0.640 | 2.836 | Hs578T Rapamycin 3 |
| Hs 578T | TGX221 | 3 | 72 | 0.001 | 4078.5 | 4028.3 | 571.3 | -3.0 | 1.010 | 1.010 | 2.818 | Hs578T TGX221 3 |