Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
HCC38 Everolimus 2 72
0.001
 2094.3 3106.8 690.5
-3.0
 0.668 0.674 2.170
HCC38 Everolimus 0 2 72
HCC38 Pictilisib 2 72
0.001
 2725.8 2985.8 690.5
-3.0
 0.916 0.913 2.112
HCC38 GDC0941 0 2 72
HCC38 GDC-0980 2 72
0.001
 3094.3 3084.3 690.5
-3.0
 1.000 1.000 2.159
HCC38 GDC0980 0 2 72
HCC38 Omipalisib 2 72
0.001
 2372.8 3009.3 690.5
-3.0
 0.788 0.788 2.124
HCC38 GSK458 0 2 72
HCC38 KIN001-244 2 72
0.001
 3129.0 3196.0 690.5
-3.0
 0.981 0.979 2.210
HCC38 KIN001-244 0 2 72
HCC38 MK2206 2 72
0.001
 3051.8 3083.8 690.5
-3.0
 0.990 0.990 2.159
HCC38 MK2206 0 2 72
HCC38 PI103 2 72
0.001
 2917.5 2947.5 690.5
-3.0
 0.990 0.990 2.094
HCC38 PI103 0 2 72
HCC38 PIK-93 2 72
0.001
 3053.0 2975.5 690.5
-3.0
 1.020 1.030 2.107
HCC38 PIK93 0 2 72
HCC38 Sirolimus 2 72
0.001
 2010.5 2971.8 690.5
-3.0
 0.661 0.677 2.106
HCC38 Rapamycin 0 2 72
HCC38 TGX221 2 72
0.001
 2867.3 2993.0 690.5
-3.0
 0.960 0.958 2.116
HCC38 TGX221 0 2 72
HCC38 Torin1 2 72
0.001
 2898.0 3034.5 690.5
-3.0
 0.957 0.955 2.136
HCC38 Torin1 0 2 72
HCC38 Torin2 2 72
0.001
 2849.5 3044.5 690.5
-3.0
 0.939 0.936 2.140
HCC38 Torin2 0 2 72
HCC38 Trametinib 2 72
0.001
 2720.8 3029.5 690.5
-3.0
 0.902 0.898 2.133
HCC38 Trametinib 0 2 72
HCC38 WYE-125132 2 72
0.001
 2871.8 3050.0 690.5
-3.0
 0.945 0.942 2.143
HCC38 WYE125132 0 2 72
HCC38 XL147 2 72
0.001
 2998.5 3158.8 690.5
-3.0
 0.953 0.949 2.194
HCC38 XL147 0 2 72
HCC38 ZSTK474 2 72
0.001
 3202.3 3291.0 690.5
-3.0
 0.976 0.973 2.253
HCC38 ZSTK474 0 2 72
HCC38 AS605240 3 72
0.001
 3065.8 2994.3 1180.5
-3.0
 1.040 1.020 1.343
HCC38 AS605240 0 3 72
HCC38 AZD-6482 3 72
0.001
 3207.3 3159.3 1180.5
-3.0
 1.020 1.020 1.420
HCC38 AZD6482 0 3 72
HCC38 AZD8055 3 72
0.001
 3024.8 3151.3 1180.5
-3.0
 0.943 0.960 1.417
HCC38 AZD8055 0 3 72
HCC38 Dactolisib 3 72
0.001
 2969.3 3265.3 1180.5
-3.0
 0.875 0.909 1.468
HCC38 BEZ235 0 3 72
HCC38 Buparlisib 3 72
0.001
 3052.5 3184.0 1180.5
-3.0
 0.942 0.959 1.431
HCC38 BKM120 0 3 72
HCC38 BX-912 3 72
0.001
 3071.5 3233.3 1180.5
-3.0
 0.931 0.950 1.454
HCC38 BX912 0 3 72
HCC38 Alpelisib 3 72
0.001
 2614.8 3111.0 1180.5
-3.0
 0.766 0.840 1.398
HCC38 BYL719 0 3 72
HCC38 CAL-101 3 72
0.001
 3140.0 3209.8 1180.5
-3.0
 0.970 0.978 1.443
HCC38 CAL101 0 3 72
HCC38 Everolimus 3 72
0.001
 2398.8 3195.8 1180.5
-3.0
 0.638 0.751 1.437
HCC38 Everolimus 0 3 72