Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
Hs 578T MK2206 2 72
0.0032
 3583.0 3607.8 624.7
-2.49
 0.995 0.993 2.530
Hs578T MK2206 2
Hs 578T MK2206 2 72
3.2
 2956.8 3607.8 624.7
0.505
 0.849 0.820 2.530
Hs578T MK2206 2
Hs 578T MK2206 2 72
1.0
 2266.0 3607.8 624.7
0.0
 0.664 0.628 2.530
Hs578T MK2206 2
Hs 578T MK2206 2 72
0.32
 2629.8 3607.8 624.7
-0.495
 0.765 0.729 2.530
Hs578T MK2206 2
Hs 578T MK2206 2 72
0.1
 3038.5 3607.8 624.7
-1.0
 0.869 0.842 2.530
Hs578T MK2206 2
Hs 578T MK2206 2 72
0.032
 3360.8 3607.8 624.7
-1.49
 0.945 0.932 2.530
Hs578T MK2206 2
Hs 578T MK2206 2 72
0.01
 3314.8 3607.8 624.7
-2.0
 0.934 0.919 2.530
Hs578T MK2206 2
Hs 578T MK2206 2 72
0.001
 3466.3 3607.8 624.7
-3.0
 0.969 0.961 2.530
Hs578T MK2206 2
Hs 578T MK2206 3 72
0.001
 4169.3 4213.3 571.3
-3.0
 0.993 0.990 2.883
Hs578T MK2206 3
Hs 578T MK2206 3 72
0.0032
 4157.8 4213.3 571.3
-2.49
 0.991 0.987 2.883
Hs578T MK2206 3
Hs 578T MK2206 3 72
0.01
 4132.8 4213.3 571.3
-2.0
 0.987 0.981 2.883
Hs578T MK2206 3
Hs 578T MK2206 3 72
0.032
 4056.0 4213.3 571.3
-1.49
 0.974 0.963 2.883
Hs578T MK2206 3
Hs 578T MK2206 3 72
0.1
 3787.8 4213.3 571.3
-1.0
 0.927 0.899 2.883
Hs578T MK2206 3
Hs 578T MK2206 3 72
0.32
 3171.5 4213.3 571.3
-0.495
 0.812 0.753 2.883
Hs578T MK2206 3
Hs 578T MK2206 3 72
1.0
 2805.5 4213.3 571.3
0.0
 0.737 0.666 2.883
Hs578T MK2206 3
Hs 578T MK2206 3 72
3.2
 3111.8 4213.3 571.3
0.505
 0.800 0.739 2.883
Hs578T MK2206 3
Hs 578T PI103 1 72
3.2
 744.5 3645.8 873.1
0.505
 -0.074 0.204 2.062
Hs578T PI103 1
Hs 578T PI103 1 72
1.0
 884.3 3645.8 873.1
0.0
 0.006 0.243 2.062
Hs578T PI103 1
Hs 578T PI103 1 72
0.32
 1476.3 3645.8 873.1
-0.495
 0.290 0.405 2.062
Hs578T PI103 1
Hs 578T PI103 1 72
0.1
 2154.8 3645.8 873.1
-1.0
 0.550 0.591 2.062
Hs578T PI103 1
Hs 578T PI103 1 72
0.032
 3009.5 3645.8 873.1
-1.49
 0.822 0.825 2.062
Hs578T PI103 1
Hs 578T PI103 1 72
0.01
 3296.8 3645.8 873.1
-2.0
 0.905 0.904 2.062
Hs578T PI103 1
Hs 578T PI103 1 72
0.0032
 3491.0 3645.8 873.1
-2.49
 0.958 0.958 2.062
Hs578T PI103 1
Hs 578T PI103 1 72
0.001
 3457.5 3645.8 873.1
-3.0
 0.949 0.948 2.062
Hs578T PI103 1
Hs 578T PI103 2 72
0.0032
 3439.5 3540.3 624.7
-2.49
 0.977 0.972 2.503
Hs578T PI103 2