Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | GDC-0980 | 2 | 72 | 0.001 | 3333.5 | 3217.8 | 1018.6 | -3.0 | 1.040 | 1.040 | 1.659 | BT20 GDC0980 0 2 |
| BT-20 | GDC-0980 | 2 | 72 | 0.32 | 749.3 | 3217.8 | 1018.6 | -0.495 | -0.169 | 0.233 | 1.659 | BT20 GDC0980 0 2 |
| BT-20 | GDC-0980 | 2 | 72 | 0.01 | 3079.3 | 3217.8 | 1018.6 | -2.0 | 0.948 | 0.957 | 1.659 | BT20 GDC0980 0 2 |
| BT-20 | GDC-0980 | 2 | 72 | 1.0 | 611.3 | 3217.8 | 1018.6 | 0.0 | -0.265 | 0.190 | 1.659 | BT20 GDC0980 0 2 |
| BT-20 | GDC-0980 | 2 | 72 | 3.2 | 420.0 | 3217.8 | 1018.6 | 0.505 | -0.414 | 0.131 | 1.659 | BT20 GDC0980 0 2 |
| BT-20 | GDC-0980 | 2 | 72 | 0.032 | 2409.5 | 3217.8 | 1018.6 | -1.49 | 0.680 | 0.749 | 1.659 | BT20 GDC0980 0 2 |
| BT-20 | GDC-0980 | 3 | 72 | 0.32 | 807.5 | 3324.8 | 586.9 | -0.495 | 0.136 | 0.243 | 2.502 | BT20 GDC0980 0 3 |
| BT-20 | GDC-0980 | 3 | 72 | 1.0 | 578.3 | 3324.8 | 586.9 | 0.0 | -0.006 | 0.174 | 2.502 | BT20 GDC0980 0 3 |
| BT-20 | GDC-0980 | 3 | 72 | 3.2 | 432.8 | 3324.8 | 586.9 | 0.505 | -0.115 | 0.130 | 2.502 | BT20 GDC0980 0 3 |
| BT-20 | GDC-0980 | 3 | 72 | 0.1 | 1475.0 | 3324.8 | 586.9 | -1.0 | 0.445 | 0.444 | 2.502 | BT20 GDC0980 0 3 |
| BT-20 | GDC-0980 | 3 | 72 | 0.032 | 2882.3 | 3324.8 | 586.9 | -1.49 | 0.889 | 0.867 | 2.502 | BT20 GDC0980 0 3 |
| BT-20 | GDC-0980 | 3 | 72 | 0.01 | 3349.8 | 3324.8 | 586.9 | -2.0 | 1.010 | 1.010 | 2.502 | BT20 GDC0980 0 3 |
| BT-20 | GDC-0980 | 3 | 72 | 0.0032 | 3421.5 | 3324.8 | 586.9 | -2.49 | 1.020 | 1.030 | 2.502 | BT20 GDC0980 0 3 |
| BT-20 | GDC-0980 | 3 | 72 | 0.001 | 3400.5 | 3324.8 | 586.9 | -3.0 | 1.020 | 1.020 | 2.502 | BT20 GDC0980 0 3 |
| BT-20 | Omipalisib | 1 | 72 | 0.001 | 5515.0 | 6095.3 | 1443.3 | -3.0 | 0.906 | 0.905 | 2.078 | BT20 GSK458 0 1 |
| BT-20 | Omipalisib | 1 | 72 | 3.2 | 95.5 | 6095.3 | 1443.3 | 0.505 | -0.729 | 0.016 | 2.078 | BT20 GSK458 0 1 |
| BT-20 | Omipalisib | 1 | 72 | 1.0 | 262.3 | 6095.3 | 1443.3 | 0.0 | -0.560 | 0.043 | 2.078 | BT20 GSK458 0 1 |
| BT-20 | Omipalisib | 1 | 72 | 0.32 | 819.0 | 6095.3 | 1443.3 | -0.495 | -0.239 | 0.134 | 2.078 | BT20 GSK458 0 1 |
| BT-20 | Omipalisib | 1 | 72 | 0.1 | 1000.3 | 6095.3 | 1443.3 | -1.0 | -0.162 | 0.164 | 2.078 | BT20 GSK458 0 1 |
| BT-20 | Omipalisib | 1 | 72 | 0.032 | 1381.0 | 6095.3 | 1443.3 | -1.49 | -0.021 | 0.227 | 2.078 | BT20 GSK458 0 1 |
| BT-20 | Omipalisib | 1 | 72 | 0.01 | 2601.0 | 6095.3 | 1443.3 | -2.0 | 0.328 | 0.427 | 2.078 | BT20 GSK458 0 1 |
| BT-20 | Omipalisib | 1 | 72 | 0.0032 | 4184.5 | 6095.3 | 1443.3 | -2.49 | 0.669 | 0.687 | 2.078 | BT20 GSK458 0 1 |
| BT-20 | Omipalisib | 2 | 72 | 0.0032 | 2069.3 | 3349.0 | 1018.6 | -2.49 | 0.511 | 0.618 | 1.717 | BT20 GSK458 0 2 |
| BT-20 | Omipalisib | 2 | 72 | 0.1 | 664.8 | 3349.0 | 1018.6 | -1.0 | -0.220 | 0.199 | 1.717 | BT20 GSK458 0 2 |
| BT-20 | Omipalisib | 2 | 72 | 0.32 | 541.3 | 3349.0 | 1018.6 | -0.495 | -0.308 | 0.162 | 1.717 | BT20 GSK458 0 2 |