Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
HCC38 Buparlisib 2 72
1.0
 1471.0 3048.5 690.5
0.0
 0.423 0.483 2.142
HCC38 BKM120 0 2 72
HCC38 Buparlisib 2 72
0.032
 3141.0 3048.5 690.5
-1.49
 1.030 1.030 2.142
HCC38 BKM120 0 2 72
HCC38 Buparlisib 2 72
0.1
 2958.8 3048.5 690.5
-1.0
 0.972 0.971 2.142
HCC38 BKM120 0 2 72
HCC38 Buparlisib 2 72
0.32
 2663.3 3048.5 690.5
-0.495
 0.878 0.874 2.142
HCC38 BKM120 0 2 72
HCC38 WYE-125132 2 72
1.0
 985.5 3050.0 690.5
0.0
 0.181 0.323 2.143
HCC38 WYE125132 0 2 72
HCC38 WYE-125132 2 72
0.01
 2479.3 3050.0 690.5
-2.0
 0.816 0.813 2.143
HCC38 WYE125132 0 2 72
HCC38 WYE-125132 2 72
0.032
 1949.0 3050.0 690.5
-1.49
 0.623 0.639 2.143
HCC38 WYE125132 0 2 72
HCC38 WYE-125132 2 72
0.1
 1414.8 3050.0 690.5
-1.0
 0.398 0.464 2.143
HCC38 WYE125132 0 2 72
HCC38 WYE-125132 2 72
3.2
 929.8 3050.0 690.5
0.505
 0.149 0.305 2.143
HCC38 WYE125132 0 2 72
HCC38 WYE-125132 2 72
0.32
 1061.0 3050.0 690.5
-0.495
 0.222 0.348 2.143
HCC38 WYE125132 0 2 72
HCC38 WYE-125132 2 72
0.001
 2871.8 3050.0 690.5
-3.0
 0.945 0.942 2.143
HCC38 WYE125132 0 2 72
HCC38 WYE-125132 2 72
0.0032
 2749.3 3050.0 690.5
-2.49
 0.905 0.901 2.143
HCC38 WYE125132 0 2 72
HCC38 CAL-101 2 72
1.0
 2843.0 3073.0 690.5
0.0
 0.929 0.925 2.154
HCC38 CAL101 0 2 72
HCC38 CAL-101 2 72
0.001
 3075.8 3073.0 690.5
-3.0
 1.000 1.000 2.154
HCC38 CAL101 0 2 72
HCC38 CAL-101 2 72
0.32
 3061.5 3073.0 690.5
-0.495
 0.997 0.996 2.154
HCC38 CAL101 0 2 72
HCC38 CAL-101 2 72
0.0032
 3088.8 3073.0 690.5
-2.49
 1.000 1.010 2.154
HCC38 CAL101 0 2 72
HCC38 CAL-101 2 72
0.032
 3149.8 3073.0 690.5
-1.49
 1.020 1.020 2.154
HCC38 CAL101 0 2 72
HCC38 CAL-101 2 72
3.2
 2692.3 3073.0 690.5
0.505
 0.881 0.876 2.154
HCC38 CAL101 0 2 72
HCC38 CAL-101 2 72
0.1
 3062.0 3073.0 690.5
-1.0
 0.997 0.996 2.154
HCC38 CAL101 0 2 72
HCC38 CAL-101 2 72
0.01
 2962.3 3073.0 690.5
-2.0
 0.966 0.964 2.154
HCC38 CAL101 0 2 72
HCC38 PIK-93 3 72
3.2
 2257.8 3077.8 1180.5
0.505
 0.598 0.734 1.382
HCC38 PIK93 0 3 72
HCC38 PIK-93 3 72
0.032
 3023.8 3077.8 1180.5
-1.49
 0.975 0.982 1.382
HCC38 PIK93 0 3 72
HCC38 PIK-93 3 72
0.1
 3135.5 3077.8 1180.5
-1.0
 1.030 1.020 1.382
HCC38 PIK93 0 3 72
HCC38 PIK-93 3 72
0.32
 3011.8 3077.8 1180.5
-0.495
 0.969 0.979 1.382
HCC38 PIK93 0 3 72
HCC38 PIK-93 3 72
0.01
 2884.0 3077.8 1180.5
-2.0
 0.908 0.937 1.382
HCC38 PIK93 0 3 72