Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
HCC70 Omipalisib 2 72
0.1
 443.3 2319.3 722.8
-1.0
 -0.252 0.191 1.682
HCC70 GSK458 0 2 72
HCC70 Omipalisib 2 72
0.32
 281.3 2319.3 722.8
-0.495
 -0.429 0.121 1.682
HCC70 GSK458 0 2 72
HCC70 Omipalisib 2 72
3.2
 92.5 2319.3 722.8
0.505
 -0.705 0.040 1.682
HCC70 GSK458 0 2 72
HCC70 Omipalisib 2 72
0.0032
 1914.8 2319.3 722.8
-2.49
 0.785 0.826 1.682
HCC70 GSK458 0 2 72
HCC70 Omipalisib 2 72
0.01
 1292.5 2319.3 722.8
-2.0
 0.413 0.557 1.682
HCC70 GSK458 0 2 72
HCC70 Omipalisib 2 72
0.032
 711.8 2319.3 722.8
-1.49
 -0.009 0.307 1.682
HCC70 GSK458 0 2 72
HCC70 Omipalisib 2 72
0.001
 1942.5 2319.3 722.8
-3.0
 0.800 0.838 1.682
HCC70 GSK458 0 2 72
HCC70 KIN001-244 2 72
0.1
 2388.8 2323.3 722.8
-1.0
 1.030 1.030 1.684
HCC70 KIN001-244 0 2 72
HCC70 KIN001-244 2 72
0.32
 2345.3 2323.3 722.8
-0.495
 1.010 1.010 1.684
HCC70 KIN001-244 0 2 72
HCC70 KIN001-244 2 72
0.032
 2347.8 2323.3 722.8
-1.49
 1.010 1.010 1.684
HCC70 KIN001-244 0 2 72
HCC70 KIN001-244 2 72
1.0
 2412.3 2323.3 722.8
0.0
 1.050 1.040 1.684
HCC70 KIN001-244 0 2 72
HCC70 KIN001-244 2 72
0.001
 2278.0 2323.3 722.8
-3.0
 0.977 0.981 1.684
HCC70 KIN001-244 0 2 72
HCC70 KIN001-244 2 72
0.0032
 2411.5 2323.3 722.8
-2.49
 1.040 1.040 1.684
HCC70 KIN001-244 0 2 72
HCC70 KIN001-244 2 72
0.01
 2436.0 2323.3 722.8
-2.0
 1.060 1.050 1.684
HCC70 KIN001-244 0 2 72
HCC70 KIN001-244 2 72
3.2
 2127.5 2323.3 722.8
0.505
 0.898 0.916 1.684
HCC70 KIN001-244 0 2 72
HCC70 MK2206 2 72
0.001
 2488.5 2332.3 722.8
-3.0
 1.080 1.070 1.690
HCC70 MK2206 0 2 72
HCC70 MK2206 2 72
3.2
 1045.5 2332.3 722.8
0.505
 0.244 0.448 1.690
HCC70 MK2206 0 2 72
HCC70 MK2206 2 72
0.032
 2371.0 2332.3 722.8
-1.49
 1.020 1.020 1.690
HCC70 MK2206 0 2 72
HCC70 MK2206 2 72
0.1
 2029.8 2332.3 722.8
-1.0
 0.842 0.870 1.690
HCC70 MK2206 0 2 72
HCC70 MK2206 2 72
0.32
 1610.5 2332.3 722.8
-0.495
 0.606 0.691 1.690
HCC70 MK2206 0 2 72
HCC70 MK2206 2 72
0.0032
 2410.8 2332.3 722.8
-2.49
 1.040 1.030 1.690
HCC70 MK2206 0 2 72
HCC70 MK2206 2 72
0.01
 2536.8 2332.3 722.8
-2.0
 1.100 1.090 1.690
HCC70 MK2206 0 2 72
HCC70 MK2206 2 72
1.0
 1172.5 2332.3 722.8
0.0
 0.331 0.503 1.690
HCC70 MK2206 0 2 72
HCC70 BX-912 2 72
1.0
 1866.5 2337.5 722.8
0.0
 0.751 0.799 1.693
HCC70 BX912 0 2 72
HCC70 BX-912 2 72
0.1
 2469.0 2337.5 722.8
-1.0
 1.070 1.060 1.693
HCC70 BX912 0 2 72