Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | AS605240 | 3 | 72 | 0.01 | 2809.8 | 2821.5 | 517.3 | -2.0 | 0.997 | 0.996 | 2.447 | HCC70 AS605240 0 3 72 |
| HCC70 | AS605240 | 3 | 72 | 0.032 | 2913.0 | 2821.5 | 517.3 | -1.49 | 1.030 | 1.030 | 2.447 | HCC70 AS605240 0 3 72 |
| HCC70 | AS605240 | 3 | 72 | 0.32 | 2196.8 | 2821.5 | 517.3 | -0.495 | 0.806 | 0.779 | 2.447 | HCC70 AS605240 0 3 72 |
| HCC70 | AS605240 | 3 | 72 | 1.0 | 1850.8 | 2821.5 | 517.3 | 0.0 | 0.683 | 0.656 | 2.447 | HCC70 AS605240 0 3 72 |
| HCC70 | AS605240 | 3 | 72 | 0.1 | 2523.0 | 2821.5 | 517.3 | -1.0 | 0.911 | 0.894 | 2.447 | HCC70 AS605240 0 3 72 |
| HCC70 | Pictilisib | 3 | 72 | 0.032 | 2930.3 | 2827.0 | 517.3 | -1.49 | 1.030 | 1.040 | 2.450 | HCC70 GDC0941 0 3 72 |
| HCC70 | Pictilisib | 3 | 72 | 0.0032 | 3088.5 | 2827.0 | 517.3 | -2.49 | 1.070 | 1.090 | 2.450 | HCC70 GDC0941 0 3 72 |
| HCC70 | Pictilisib | 3 | 72 | 1.0 | 1619.0 | 2827.0 | 517.3 | 0.0 | 0.593 | 0.573 | 2.450 | HCC70 GDC0941 0 3 72 |
| HCC70 | Pictilisib | 3 | 72 | 0.001 | 2889.0 | 2827.0 | 517.3 | -3.0 | 1.020 | 1.020 | 2.450 | HCC70 GDC0941 0 3 72 |
| HCC70 | Pictilisib | 3 | 72 | 0.1 | 2809.0 | 2827.0 | 517.3 | -1.0 | 0.995 | 0.994 | 2.450 | HCC70 GDC0941 0 3 72 |
| HCC70 | Pictilisib | 3 | 72 | 3.2 | 992.8 | 2827.0 | 517.3 | 0.505 | 0.305 | 0.351 | 2.450 | HCC70 GDC0941 0 3 72 |
| HCC70 | Pictilisib | 3 | 72 | 0.32 | 2468.3 | 2827.0 | 517.3 | -0.495 | 0.892 | 0.873 | 2.450 | HCC70 GDC0941 0 3 72 |
| HCC70 | Pictilisib | 3 | 72 | 0.01 | 2986.0 | 2827.0 | 517.3 | -2.0 | 1.050 | 1.060 | 2.450 | HCC70 GDC0941 0 3 72 |
| HCC70 | Omipalisib | 3 | 72 | 1.0 | 228.8 | 2841.5 | 517.3 | 0.0 | -0.283 | 0.081 | 2.458 | HCC70 GSK458 0 3 72 |
| HCC70 | Omipalisib | 3 | 72 | 0.1 | 554.0 | 2841.5 | 517.3 | -1.0 | 0.028 | 0.195 | 2.458 | HCC70 GSK458 0 3 72 |
| HCC70 | Omipalisib | 3 | 72 | 0.032 | 856.0 | 2841.5 | 517.3 | -1.49 | 0.227 | 0.301 | 2.458 | HCC70 GSK458 0 3 72 |
| HCC70 | Omipalisib | 3 | 72 | 3.2 | 145.0 | 2841.5 | 517.3 | 0.505 | -0.404 | 0.051 | 2.458 | HCC70 GSK458 0 3 72 |
| HCC70 | Omipalisib | 3 | 72 | 0.0032 | 2327.0 | 2841.5 | 517.3 | -2.49 | 0.844 | 0.819 | 2.458 | HCC70 GSK458 0 3 72 |
| HCC70 | Omipalisib | 3 | 72 | 0.001 | 2652.0 | 2841.5 | 517.3 | -3.0 | 0.945 | 0.933 | 2.458 | HCC70 GSK458 0 3 72 |
| HCC70 | Omipalisib | 3 | 72 | 0.32 | 379.8 | 2841.5 | 517.3 | -0.495 | -0.118 | 0.134 | 2.458 | HCC70 GSK458 0 3 72 |
| HCC70 | Omipalisib | 3 | 72 | 0.01 | 1722.3 | 2841.5 | 517.3 | -2.0 | 0.631 | 0.606 | 2.458 | HCC70 GSK458 0 3 72 |
| HCC70 | TGX221 | 3 | 72 | 0.0032 | 2821.3 | 2844.8 | 517.3 | -2.49 | 0.993 | 0.992 | 2.459 | HCC70 TGX221 0 3 72 |
| HCC70 | TGX221 | 3 | 72 | 0.001 | 2874.3 | 2844.8 | 517.3 | -3.0 | 1.010 | 1.010 | 2.459 | HCC70 TGX221 0 3 72 |
| HCC70 | TGX221 | 3 | 72 | 3.2 | 1908.0 | 2844.8 | 517.3 | 0.505 | 0.700 | 0.671 | 2.459 | HCC70 TGX221 0 3 72 |
| HCC70 | TGX221 | 3 | 72 | 0.1 | 2521.5 | 2844.8 | 517.3 | -1.0 | 0.904 | 0.886 | 2.459 | HCC70 TGX221 0 3 72 |