Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | Omipalisib | 2 | 72 | 1.0 | 235.0 | 3349.0 | 1018.6 | 0.0 | -0.574 | 0.070 | 1.717 | BT20 GSK458 0 2 |
| BT-20 | Buparlisib | 3 | 72 | 3.2 | 235.8 | 3388.3 | 586.9 | 0.505 | -0.303 | 0.070 | 2.529 | BT20 BKM120 0 3 |
| HCC70 | Omipalisib | 1 | 72 | 1.0 | 253.0 | 3280.0 | 1279.8 | 0.0 | -0.697 | 0.077 | 1.358 | HCC70 GSK458 0 1 72 |
| Hs 578T | Omipalisib | 2 | 72 | 1.0 | 258.0 | 3550.3 | 624.7 | 0.0 | -0.297 | 0.073 | 2.507 | Hs578T GSK458 2 |
| BT-20 | Omipalisib | 1 | 72 | 1.0 | 262.3 | 6095.3 | 1443.3 | 0.0 | -0.560 | 0.043 | 2.078 | BT20 GSK458 0 1 |
| HCC70 | Omipalisib | 2 | 72 | 0.32 | 281.3 | 2319.3 | 722.8 | -0.495 | -0.429 | 0.121 | 1.682 | HCC70 GSK458 0 2 72 |
| HCC38 | Torin2 | 2 | 72 | 1.0 | 295.3 | 3044.5 | 690.5 | 0.0 | -0.328 | 0.097 | 2.140 | HCC38 Torin2 0 2 72 |
| Hs 578T | Torin2 | 1 | 72 | 3.2 | 303.8 | 3568.0 | 873.1 | 0.505 | -0.405 | 0.085 | 2.031 | Hs578T Torin2 1 |
| HCC38 | Torin2 | 3 | 72 | 3.2 | 304.0 | 3083.5 | 1180.5 | 0.505 | -0.624 | 0.099 | 1.385 | HCC38 Torin2 0 3 72 |
| BT-20 | Torin2 | 3 | 72 | 1.0 | 307.3 | 3225.3 | 586.9 | 0.0 | -0.231 | 0.095 | 2.458 | BT20 Torin2 0 3 |
| Hs 578T | Torin2 | 3 | 72 | 1.0 | 337.8 | 4103.3 | 571.3 | 0.0 | -0.169 | 0.082 | 2.844 | Hs578T Torin2 3 |
| HCC70 | Buparlisib | 3 | 72 | 3.2 | 341.8 | 2804.3 | 517.3 | 0.505 | -0.156 | 0.122 | 2.439 | HCC70 BKM120 0 3 72 |
| HCC70 | Torin2 | 3 | 72 | 1.0 | 358.5 | 2778.8 | 517.3 | 0.0 | -0.140 | 0.129 | 2.425 | HCC70 Torin2 0 3 72 |
| BT-20 | Buparlisib | 2 | 72 | 3.2 | 359.5 | 3408.8 | 1018.6 | 0.505 | -0.450 | 0.105 | 1.743 | BT20 BKM120 0 2 |
| HCC70 | Omipalisib | 3 | 72 | 0.32 | 379.8 | 2841.5 | 517.3 | -0.495 | -0.118 | 0.134 | 2.458 | HCC70 GSK458 0 3 72 |
| HCC70 | Omipalisib | 1 | 72 | 0.32 | 383.8 | 3280.0 | 1279.8 | -0.495 | -0.588 | 0.117 | 1.358 | HCC70 GSK458 0 1 72 |
| HCC38 | BX-912 | 2 | 72 | 3.2 | 390.8 | 3142.0 | 690.5 | 0.505 | -0.229 | 0.124 | 2.186 | HCC38 BX912 0 2 72 |
| Hs 578T | Omipalisib | 3 | 72 | 3.2 | 412.8 | 4175.0 | 571.3 | 0.505 | -0.107 | 0.099 | 2.869 | Hs578T GSK458 3 |
| HCC70 | Buparlisib | 2 | 72 | 3.2 | 418.0 | 2387.5 | 722.8 | 0.505 | -0.272 | 0.175 | 1.724 | HCC70 BKM120 0 2 72 |
| BT-20 | AZD8055 | 2 | 72 | 3.2 | 419.0 | 3421.5 | 1018.6 | 0.505 | -0.398 | 0.122 | 1.748 | BT20 AZD8055 0 2 |
| BT-20 | GDC-0980 | 2 | 72 | 3.2 | 420.0 | 3217.8 | 1018.6 | 0.505 | -0.414 | 0.131 | 1.659 | BT20 GDC0980 0 2 |
| HCC38 | Omipalisib | 3 | 72 | 3.2 | 429.5 | 3215.3 | 1180.5 | 0.505 | -0.503 | 0.134 | 1.446 | HCC38 GSK458 0 3 72 |
| BT-20 | GDC-0980 | 3 | 72 | 3.2 | 432.8 | 3324.8 | 586.9 | 0.505 | -0.115 | 0.130 | 2.502 | BT20 GDC0980 0 3 |
| HCC70 | Omipalisib | 2 | 72 | 0.1 | 443.3 | 2319.3 | 722.8 | -1.0 | -0.252 | 0.191 | 1.682 | HCC70 GSK458 0 2 72 |
| HCC38 | Buparlisib | 2 | 72 | 3.2 | 445.0 | 3048.5 | 690.5 | 0.505 | -0.185 | 0.146 | 2.142 | HCC38 BKM120 0 2 72 |