Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | TGX221 | 1 | 72 | 0.0032 | 11187.8 | 11158.5 | 1742.8 | -2.49 | 1.000 | 1.000 | 2.679 | HCC1806 TGX221 0 1 72 |
| HCC1806 | PIK-93 | 1 | 72 | 0.0032 | 11204.3 | 11752.8 | 1742.8 | -2.49 | 0.966 | 0.953 | 2.753 | HCC1806 PIK93 0 1 72 |
| HCC1806 | PIK-93 | 2 | 72 | 0.0032 | 11204.3 | 11752.8 | 1643.3 | -2.49 | 0.967 | 0.953 | 2.838 | HCC1806 PIK93 0 2 72 |
| HCC1806 | PIK-93 | 3 | 72 | 0.0032 | 11204.3 | 11752.8 | 1273.3 | -2.49 | 0.970 | 0.953 | 3.206 | HCC1806 PIK93 0 3 72 |
| HCC1806 | TGX221 | 2 | 72 | 1.0 | 11205.8 | 11158.5 | 1643.3 | 0.0 | 1.000 | 1.000 | 2.763 | HCC1806 TGX221 0 2 72 |
| HCC1806 | TGX221 | 1 | 72 | 1.0 | 11205.8 | 11158.5 | 1742.8 | 0.0 | 1.000 | 1.000 | 2.679 | HCC1806 TGX221 0 1 72 |
| HCC1806 | TGX221 | 3 | 72 | 1.0 | 11205.8 | 11158.5 | 1273.3 | 0.0 | 1.000 | 1.000 | 3.132 | HCC1806 TGX221 0 3 72 |
| HCC1806 | GDC-0980 | 1 | 72 | 0.01 | 11207.3 | 11293.0 | 1742.8 | -2.0 | 0.994 | 0.992 | 2.696 | HCC1806 GDC0980 0 1 72 |
| HCC1806 | GDC-0980 | 2 | 72 | 0.01 | 11207.3 | 11293.0 | 1643.3 | -2.0 | 0.995 | 0.992 | 2.781 | HCC1806 GDC0980 0 2 72 |
| HCC1806 | GDC-0980 | 3 | 72 | 0.01 | 11207.3 | 11293.0 | 1273.3 | -2.0 | 0.995 | 0.992 | 3.149 | HCC1806 GDC0980 0 3 72 |
| HCC1806 | Alpelisib | 3 | 72 | 1.0 | 11213.0 | 11894.0 | 1273.3 | 0.0 | 0.964 | 0.943 | 3.224 | HCC1806 BYL719 0 3 72 |
| HCC1806 | Alpelisib | 1 | 72 | 1.0 | 11213.0 | 11894.0 | 1742.8 | 0.0 | 0.958 | 0.943 | 2.771 | HCC1806 BYL719 0 1 72 |
| HCC1806 | Alpelisib | 2 | 72 | 1.0 | 11213.0 | 11894.0 | 1643.3 | 0.0 | 0.959 | 0.943 | 2.856 | HCC1806 BYL719 0 2 72 |
| HCC1806 | GDC-0980 | 2 | 72 | 0.0032 | 11217.3 | 11293.0 | 1643.3 | -2.49 | 0.995 | 0.993 | 2.781 | HCC1806 GDC0980 0 2 72 |
| HCC1806 | GDC-0980 | 1 | 72 | 0.0032 | 11217.3 | 11293.0 | 1742.8 | -2.49 | 0.995 | 0.993 | 2.696 | HCC1806 GDC0980 0 1 72 |
| HCC1806 | GDC-0980 | 3 | 72 | 0.0032 | 11217.3 | 11293.0 | 1273.3 | -2.49 | 0.996 | 0.993 | 3.149 | HCC1806 GDC0980 0 3 72 |
| HCC1806 | TGX221 | 3 | 72 | 0.01 | 11230.5 | 11158.5 | 1273.3 | -2.0 | 1.000 | 1.010 | 3.132 | HCC1806 TGX221 0 3 72 |
| HCC1806 | TGX221 | 1 | 72 | 0.01 | 11230.5 | 11158.5 | 1742.8 | -2.0 | 1.000 | 1.010 | 2.679 | HCC1806 TGX221 0 1 72 |
| HCC1806 | TGX221 | 2 | 72 | 0.01 | 11230.5 | 11158.5 | 1643.3 | -2.0 | 1.000 | 1.010 | 2.763 | HCC1806 TGX221 0 2 72 |
| HCC1806 | CAL-101 | 3 | 72 | 0.001 | 11230.8 | 11282.8 | 1273.3 | -3.0 | 0.997 | 0.995 | 3.147 | HCC1806 CAL101 0 3 72 |
| HCC1806 | CAL-101 | 2 | 72 | 0.001 | 11230.8 | 11282.8 | 1643.3 | -3.0 | 0.997 | 0.995 | 2.779 | HCC1806 CAL101 0 2 72 |
| HCC1806 | CAL-101 | 1 | 72 | 0.001 | 11230.8 | 11282.8 | 1742.8 | -3.0 | 0.997 | 0.995 | 2.695 | HCC1806 CAL101 0 1 72 |
| HCC1806 | PIK-93 | 2 | 72 | 0.32 | 11233.8 | 11752.8 | 1643.3 | -0.495 | 0.968 | 0.956 | 2.838 | HCC1806 PIK93 0 2 72 |
| HCC1806 | PIK-93 | 3 | 72 | 0.32 | 11233.8 | 11752.8 | 1273.3 | -0.495 | 0.972 | 0.956 | 3.206 | HCC1806 PIK93 0 3 72 |
| HCC1806 | PIK-93 | 1 | 72 | 0.32 | 11233.8 | 11752.8 | 1742.8 | -0.495 | 0.967 | 0.956 | 2.753 | HCC1806 PIK93 0 1 72 |