Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | WYE-125132 | 2 | 72 | 0.32 | 1061.0 | 3050.0 | 690.5 | -0.495 | 0.222 | 0.348 | 2.143 | HCC38 WYE125132 0 2 72 |
| BT-20 | AZD-6482 | 2 | 72 | 3.2 | 1061.3 | 3186.5 | 1018.6 | 0.505 | 0.025 | 0.333 | 1.645 | BT20 AZD6482 0 2 |
| HCC38 | AZD8055 | 2 | 72 | 0.32 | 1064.5 | 3018.8 | 690.5 | -0.495 | 0.226 | 0.353 | 2.128 | HCC38 AZD8055 0 2 72 |
| BT-20 | Omipalisib | 2 | 72 | 0.01 | 1065.3 | 3349.0 | 1018.6 | -2.0 | 0.026 | 0.318 | 1.717 | BT20 GSK458 0 2 |
| Hs 578T | Torin2 | 3 | 72 | 0.1 | 1072.5 | 4103.3 | 571.3 | -1.0 | 0.248 | 0.261 | 2.844 | Hs578T Torin2 3 |
| HCC70 | AZD-6482 | 2 | 72 | 3.2 | 1082.3 | 2468.8 | 722.8 | 0.505 | 0.256 | 0.438 | 1.772 | HCC70 AZD6482 0 2 72 |
| BT-549 | Omipalisib | 3 | 72 | 0.32 | 1093.3 | 4029.3 | 1175.8 | -0.495 | -0.040 | 0.271 | 1.777 | BT549 GSK458 0 3 72 |
| Hs 578T | Dactolisib | 1 | 72 | 0.32 | 1095.0 | 3608.8 | 873.1 | -0.495 | 0.117 | 0.303 | 2.047 | Hs578T BEZ235 1 |
| Hs 578T | AZD8055 | 3 | 72 | 3.2 | 1096.0 | 4224.8 | 571.3 | 0.505 | 0.253 | 0.259 | 2.886 | Hs578T AZD8055 3 |
| HCC70 | ZSTK474 | 3 | 72 | 1.0 | 1101.3 | 2931.3 | 517.3 | 0.0 | 0.352 | 0.376 | 2.502 | HCC70 ZSTK474 0 3 72 |
| HCC70 | Pictilisib | 1 | 72 | 3.2 | 1105.0 | 3399.0 | 1279.8 | 0.505 | -0.099 | 0.325 | 1.409 | HCC70 GDC0941 0 1 72 |
| Hs 578T | AZD8055 | 3 | 72 | 0.32 | 1113.3 | 4224.8 | 571.3 | -0.495 | 0.260 | 0.264 | 2.886 | Hs578T AZD8055 3 |
| Hs 578T | Torin1 | 2 | 72 | 0.1 | 1119.5 | 3653.5 | 624.7 | -1.0 | 0.257 | 0.306 | 2.548 | Hs578T Torin1 2 |
| BT-549 | Torin2 | 3 | 72 | 0.32 | 1119.5 | 3597.8 | 1175.8 | -0.495 | -0.030 | 0.311 | 1.613 | BT549 Torin2 0 3 72 |
| BT-20 | GDC-0980 | 2 | 72 | 0.1 | 1119.8 | 3217.8 | 1018.6 | -1.0 | 0.059 | 0.348 | 1.659 | BT20 GDC0980 0 2 |
| Hs 578T | ZSTK474 | 1 | 72 | 3.2 | 1124.0 | 3415.3 | 873.1 | 0.505 | 0.137 | 0.329 | 1.968 | Hs578T ZSTK474 1 |
| Hs 578T | Torin1 | 1 | 72 | 0.32 | 1125.0 | 3386.5 | 873.1 | -0.495 | 0.138 | 0.332 | 1.956 | Hs578T Torin1 1 |
| BT-20 | WYE-125132 | 3 | 72 | 0.1 | 1137.8 | 3344.0 | 586.9 | -1.0 | 0.302 | 0.340 | 2.510 | BT20 WYE125132 0 3 |
| Hs 578T | GDC-0980 | 3 | 72 | 1.0 | 1138.5 | 4064.8 | 571.3 | 0.0 | 0.276 | 0.280 | 2.831 | Hs578T GDC0980 3 |
| HCC38 | Dactolisib | 3 | 72 | 0.32 | 1139.0 | 3265.3 | 1180.5 | -0.495 | -0.024 | 0.349 | 1.468 | HCC38 BEZ235 0 3 72 |
| Hs 578T | Torin2 | 1 | 72 | 0.1 | 1140.3 | 3568.0 | 873.1 | -1.0 | 0.140 | 0.320 | 2.031 | Hs578T Torin2 1 |
| Hs 578T | AZD8055 | 1 | 72 | 0.32 | 1141.3 | 3514.5 | 873.1 | -0.495 | 0.143 | 0.325 | 2.009 | Hs578T AZD8055 1 |
| HCC38 | Trametinib | 2 | 72 | 3.2 | 1143.3 | 3029.5 | 690.5 | 0.505 | 0.267 | 0.377 | 2.133 | HCC38 Trametinib 0 2 72 |
| HCC38 | WYE-125132 | 3 | 72 | 3.2 | 1143.8 | 3222.8 | 1180.5 | 0.505 | -0.022 | 0.355 | 1.449 | HCC38 WYE125132 0 3 72 |
| Hs 578T | WYE-125132 | 1 | 72 | 0.32 | 1144.5 | 3529.8 | 873.1 | -0.495 | 0.144 | 0.324 | 2.015 | Hs578T WYE125132 1 |