Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | AZD8055 | 2 | 72 | 3.2 | 947.0 | 3018.8 | 690.5 | 0.505 | 0.160 | 0.314 | 2.128 | HCC38 AZD8055 0 2 72 |
| HCC38 | Dactolisib | 3 | 72 | 1.0 | 951.0 | 3265.3 | 1180.5 | 0.0 | -0.137 | 0.291 | 1.468 | HCC38 BEZ235 0 3 72 |
| HCC70 | Torin2 | 1 | 72 | 0.32 | 957.5 | 3294.3 | 1279.8 | -0.495 | -0.192 | 0.291 | 1.364 | HCC70 Torin2 0 1 72 |
| BT-20 | Dactolisib | 3 | 72 | 0.1 | 959.5 | 3141.3 | 586.9 | -1.0 | 0.225 | 0.305 | 2.420 | BT20 BEZ235 0 3 |
| Hs 578T | Torin1 | 3 | 72 | 1.0 | 963.3 | 4147.8 | 571.3 | 0.0 | 0.200 | 0.232 | 2.860 | Hs578T Torin1 3 |
| HCC38 | AZD8055 | 2 | 72 | 1.0 | 968.3 | 3018.8 | 690.5 | 0.0 | 0.172 | 0.321 | 2.128 | HCC38 AZD8055 0 2 72 |
| HCC70 | Omipalisib | 1 | 72 | 0.032 | 968.5 | 3280.0 | 1279.8 | -1.49 | -0.186 | 0.295 | 1.358 | HCC70 GSK458 0 1 72 |
| Hs 578T | ZSTK474 | 2 | 72 | 3.2 | 968.8 | 3668.0 | 624.7 | 0.505 | 0.187 | 0.264 | 2.554 | Hs578T ZSTK474 2 |
| Hs 578T | Trametinib | 3 | 72 | 0.1 | 969.5 | 4062.0 | 571.3 | -1.0 | 0.205 | 0.239 | 2.830 | Hs578T Trametinib 3 |
| HCC38 | Torin1 | 2 | 72 | 0.32 | 974.3 | 3034.5 | 690.5 | -0.495 | 0.175 | 0.321 | 2.136 | HCC38 Torin1 0 2 72 |
| BT-20 | Dactolisib | 3 | 72 | 0.032 | 979.8 | 3141.3 | 586.9 | -1.49 | 0.236 | 0.312 | 2.420 | BT20 BEZ235 0 3 |
| HCC38 | Torin1 | 3 | 72 | 1.0 | 980.5 | 3204.3 | 1180.5 | 0.0 | -0.121 | 0.306 | 1.441 | HCC38 Torin1 0 3 72 |
| Hs 578T | WYE-125132 | 1 | 72 | 1.0 | 982.0 | 3529.8 | 873.1 | 0.0 | 0.060 | 0.278 | 2.015 | Hs578T WYE125132 1 |
| BT-20 | ZSTK474 | 3 | 72 | 1.0 | 982.5 | 3579.5 | 586.9 | 0.0 | 0.218 | 0.274 | 2.609 | BT20 ZSTK474 0 3 |
| HCC38 | WYE-125132 | 2 | 72 | 1.0 | 985.5 | 3050.0 | 690.5 | 0.0 | 0.181 | 0.323 | 2.143 | HCC38 WYE125132 0 2 72 |
| BT-20 | Buparlisib | 2 | 72 | 1.0 | 986.5 | 3408.8 | 1018.6 | 0.0 | -0.018 | 0.289 | 1.743 | BT20 BKM120 0 2 |
| HCC70 | Pictilisib | 3 | 72 | 3.2 | 992.8 | 2827.0 | 517.3 | 0.505 | 0.305 | 0.351 | 2.450 | HCC70 GDC0941 0 3 72 |
| HCC1806 | Torin2 | 3 | 72 | 1.0 | 999.5 | 11795.0 | 1273.3 | 0.0 | -0.073 | 0.085 | 3.212 | HCC1806 Torin2 0 3 72 |
| HCC1806 | Torin2 | 2 | 72 | 1.0 | 999.5 | 11795.0 | 1643.3 | 0.0 | -0.160 | 0.085 | 2.843 | HCC1806 Torin2 0 2 72 |
| HCC1806 | Torin2 | 1 | 72 | 1.0 | 999.5 | 11795.0 | 1742.8 | 0.0 | -0.183 | 0.085 | 2.759 | HCC1806 Torin2 0 1 72 |
| BT-20 | Omipalisib | 1 | 72 | 0.1 | 1000.3 | 6095.3 | 1443.3 | -1.0 | -0.162 | 0.164 | 2.078 | BT20 GSK458 0 1 |
| BT-20 | Torin1 | 3 | 72 | 0.1 | 1001.5 | 3483.3 | 586.9 | -1.0 | 0.231 | 0.288 | 2.569 | BT20 Torin1 0 3 |
| BT-20 | Buparlisib | 3 | 72 | 1.0 | 1004.3 | 3388.3 | 586.9 | 0.0 | 0.237 | 0.296 | 2.529 | BT20 BKM120 0 3 |
| Hs 578T | Omipalisib | 2 | 72 | 0.1 | 1004.5 | 3550.3 | 624.7 | -1.0 | 0.209 | 0.283 | 2.507 | Hs578T GSK458 2 |
| Hs 578T | AZD8055 | 1 | 72 | 3.2 | 1005.8 | 3514.5 | 873.1 | 0.505 | 0.073 | 0.286 | 2.009 | Hs578T AZD8055 1 |