Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | Torin2 | 3 | 72 | 3.2 | 185.0 | 4103.3 | 571.3 | 0.505 | -0.327 | 0.045 | 2.844 | Hs578T Torin2 3 |
| BT-549 | Buparlisib | 1 | 72 | 3.2 | 756.0 | 5555.8 | 1554.9 | 0.505 | -0.325 | 0.136 | 1.837 | BT549 BKM120 0 1 72 |
| HCC38 | BX-912 | 1 | 72 | 3.2 | 654.3 | 4388.5 | 1295.5 | 0.505 | -0.322 | 0.149 | 1.760 | HCC38 BX912 0 1 72 |
| HCC38 | Torin2 | 1 | 72 | 3.2 | 656.5 | 4443.3 | 1295.5 | 0.505 | -0.318 | 0.148 | 1.778 | HCC38 Torin2 0 1 72 |
| HCC38 | Omipalisib | 1 | 72 | 3.2 | 664.0 | 4389.3 | 1295.5 | 0.505 | -0.316 | 0.151 | 1.760 | HCC38 GSK458 0 1 72 |
| HCC70 | GDC-0980 | 1 | 72 | 3.2 | 772.8 | 3261.8 | 1279.8 | 0.505 | -0.312 | 0.237 | 1.350 | HCC70 GDC0980 0 1 72 |
| HCC1806 | Omipalisib | 2 | 72 | 3.2 | 569.3 | 11840.0 | 1643.3 | 0.505 | -0.311 | 0.048 | 2.849 | HCC1806 GSK458 0 2 72 |
| BT-20 | Omipalisib | 2 | 72 | 0.32 | 541.3 | 3349.0 | 1018.6 | -0.495 | -0.308 | 0.162 | 1.717 | BT20 GSK458 0 2 |
| BT-549 | Buparlisib | 2 | 72 | 3.2 | 621.8 | 4705.0 | 1249.6 | 0.505 | -0.306 | 0.132 | 1.913 | BT549 BKM120 0 2 72 |
| BT-20 | Buparlisib | 3 | 72 | 3.2 | 235.8 | 3388.3 | 586.9 | 0.505 | -0.303 | 0.070 | 2.529 | BT20 BKM120 0 3 |
| Hs 578T | Omipalisib | 2 | 72 | 1.0 | 258.0 | 3550.3 | 624.7 | 0.0 | -0.297 | 0.073 | 2.507 | Hs578T GSK458 2 |
| BT-549 | Omipalisib | 2 | 72 | 3.2 | 630.0 | 4963.8 | 1249.6 | 0.505 | -0.291 | 0.127 | 1.990 | BT549 GSK458 0 2 72 |
| BT-20 | GDC-0980 | 1 | 72 | 3.2 | 730.3 | 5778.5 | 1443.3 | 0.505 | -0.289 | 0.126 | 2.001 | BT20 GDC0980 0 1 |
| HCC70 | Omipalisib | 3 | 72 | 1.0 | 228.8 | 2841.5 | 517.3 | 0.0 | -0.283 | 0.081 | 2.458 | HCC70 GSK458 0 3 72 |
| BT-549 | Torin2 | 2 | 72 | 3.2 | 684.3 | 4425.3 | 1249.6 | 0.505 | -0.281 | 0.155 | 1.824 | BT549 Torin2 0 2 72 |
| BT-20 | AZD8055 | 2 | 72 | 1.0 | 575.0 | 3421.5 | 1018.6 | 0.0 | -0.279 | 0.168 | 1.748 | BT20 AZD8055 0 2 |
| HCC70 | Buparlisib | 2 | 72 | 3.2 | 418.0 | 2387.5 | 722.8 | 0.505 | -0.272 | 0.175 | 1.724 | HCC70 BKM120 0 2 72 |
| HCC70 | ZSTK474 | 1 | 72 | 3.2 | 849.3 | 3221.8 | 1279.8 | 0.505 | -0.265 | 0.264 | 1.332 | HCC70 ZSTK474 0 1 72 |
| BT-20 | GDC-0980 | 2 | 72 | 1.0 | 611.3 | 3217.8 | 1018.6 | 0.0 | -0.265 | 0.190 | 1.659 | BT20 GDC0980 0 2 |
| Hs 578T | Torin2 | 1 | 72 | 1.0 | 467.0 | 3568.0 | 873.1 | 0.0 | -0.265 | 0.131 | 2.031 | Hs578T Torin2 1 |
| Hs 578T | Omipalisib | 1 | 72 | 1.0 | 465.3 | 3689.5 | 873.1 | 0.0 | -0.261 | 0.126 | 2.079 | Hs578T GSK458 1 |
| HCC1806 | Buparlisib | 3 | 72 | 3.2 | 493.8 | 11660.8 | 1273.3 | 0.505 | -0.257 | 0.042 | 3.195 | HCC1806 BKM120 0 3 72 |
| BT-549 | Torin2 | 3 | 72 | 3.2 | 733.3 | 3597.8 | 1175.8 | 0.505 | -0.254 | 0.204 | 1.613 | BT549 Torin2 0 3 72 |
| HCC70 | Omipalisib | 2 | 72 | 0.1 | 443.3 | 2319.3 | 722.8 | -1.0 | -0.252 | 0.191 | 1.682 | HCC70 GSK458 0 2 72 |
| HCC38 | Torin2 | 3 | 72 | 0.32 | 791.8 | 3083.5 | 1180.5 | -0.495 | -0.251 | 0.257 | 1.385 | HCC38 Torin2 0 3 72 |