Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | XL147 | 1 | 72 | 0.1 | 5584.3 | 5624.3 | 1554.9 | -1.0 | 0.992 | 0.993 | 1.855 | BT549 XL147 0 1 72 |
| HCC70 | XL147 | 3 | 72 | 3.2 | 2979.3 | 2882.5 | 517.3 | 0.505 | 1.030 | 1.030 | 2.478 | HCC70 XL147 0 3 72 |
| BT-549 | XL147 | 1 | 72 | 0.01 | 5568.8 | 5624.3 | 1554.9 | -2.0 | 0.989 | 0.990 | 1.855 | BT549 XL147 0 1 72 |
| BT-20 | XL147 | 3 | 72 | 0.01 | 3287.5 | 3677.3 | 586.9 | -2.0 | 0.917 | 0.894 | 2.647 | BT20 XL147 0 3 |
| BT-20 | XL147 | 3 | 72 | 0.32 | 3482.5 | 3677.3 | 586.9 | -0.495 | 0.959 | 0.947 | 2.647 | BT20 XL147 0 3 |
| BT-20 | XL147 | 3 | 72 | 0.032 | 3323.3 | 3677.3 | 586.9 | -1.49 | 0.925 | 0.904 | 2.647 | BT20 XL147 0 3 |
| BT-20 | XL147 | 3 | 72 | 0.1 | 3310.0 | 3677.3 | 586.9 | -1.0 | 0.922 | 0.900 | 2.647 | BT20 XL147 0 3 |
| HCC38 | XL147 | 3 | 72 | 1.0 | 3028.8 | 3159.8 | 1180.5 | 0.0 | 0.941 | 0.959 | 1.420 | HCC38 XL147 0 3 72 |
| HCC70 | XL147 | 3 | 72 | 0.0032 | 2735.5 | 2882.5 | 517.3 | -2.49 | 0.958 | 0.949 | 2.478 | HCC70 XL147 0 3 72 |
| HCC70 | XL147 | 3 | 72 | 0.01 | 3058.8 | 2882.5 | 517.3 | -2.0 | 1.050 | 1.060 | 2.478 | HCC70 XL147 0 3 72 |
| HCC70 | XL147 | 3 | 72 | 0.032 | 2863.5 | 2882.5 | 517.3 | -1.49 | 0.995 | 0.993 | 2.478 | HCC70 XL147 0 3 72 |
| HCC70 | XL147 | 3 | 72 | 0.1 | 3026.5 | 2882.5 | 517.3 | -1.0 | 1.040 | 1.050 | 2.478 | HCC70 XL147 0 3 72 |
| BT-549 | XL147 | 3 | 72 | 0.1 | 3893.8 | 4015.3 | 1175.8 | -1.0 | 0.966 | 0.970 | 1.772 | BT549 XL147 0 3 72 |
| BT-549 | XL147 | 3 | 72 | 1.0 | 3918.0 | 4015.3 | 1175.8 | 0.0 | 0.973 | 0.976 | 1.772 | BT549 XL147 0 3 72 |
| BT-549 | XL147 | 3 | 72 | 0.032 | 3899.3 | 4015.3 | 1175.8 | -1.49 | 0.967 | 0.971 | 1.772 | BT549 XL147 0 3 72 |
| BT-549 | XL147 | 3 | 72 | 3.2 | 3779.0 | 4015.3 | 1175.8 | 0.505 | 0.933 | 0.941 | 1.772 | BT549 XL147 0 3 72 |
| BT-20 | XL147 | 3 | 72 | 3.2 | 2603.5 | 3677.3 | 586.9 | 0.505 | 0.755 | 0.708 | 2.647 | BT20 XL147 0 3 |
| BT-549 | XL147 | 3 | 72 | 0.01 | 3927.0 | 4015.3 | 1175.8 | -2.0 | 0.975 | 0.978 | 1.772 | BT549 XL147 0 3 72 |
| BT-549 | XL147 | 3 | 72 | 0.0032 | 3813.5 | 4015.3 | 1175.8 | -2.49 | 0.943 | 0.950 | 1.772 | BT549 XL147 0 3 72 |
| BT-549 | XL147 | 3 | 72 | 0.32 | 3977.8 | 4015.3 | 1175.8 | -0.495 | 0.989 | 0.991 | 1.772 | BT549 XL147 0 3 72 |
| HCC38 | XL147 | 3 | 72 | 0.0032 | 3240.0 | 3159.8 | 1180.5 | -2.49 | 1.040 | 1.030 | 1.420 | HCC38 XL147 0 3 72 |
| BT-549 | XL147 | 1 | 72 | 0.0032 | 5444.0 | 5624.3 | 1554.9 | -2.49 | 0.965 | 0.968 | 1.855 | BT549 XL147 0 1 72 |
| BT-549 | XL147 | 1 | 72 | 0.032 | 5383.3 | 5624.3 | 1554.9 | -1.49 | 0.953 | 0.957 | 1.855 | BT549 XL147 0 1 72 |
| BT-549 | XL147 | 1 | 72 | 0.32 | 5476.0 | 5624.3 | 1554.9 | -0.495 | 0.971 | 0.974 | 1.855 | BT549 XL147 0 1 72 |
| BT-20 | XL147 | 2 | 72 | 0.032 | 3497.3 | 3509.0 | 1018.6 | -1.49 | 0.996 | 0.997 | 1.784 | BT20 XL147 0 2 |