Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | Pictilisib | 3 | 72 | 0.001 | 2889.0 | 2827.0 | 517.3 | -3.0 | 1.020 | 1.020 | 2.450 | HCC70 GDC0941 0 3 72 |
| HCC1806 | ZSTK474 | 2 | 72 | 0.0032 | 11595.8 | 11395.8 | 1643.3 | -2.49 | 1.010 | 1.020 | 2.794 | HCC1806 ZSTK474 0 2 72 |
| HCC1806 | KIN001-244 | 2 | 72 | 0.001 | 11912.3 | 11660.3 | 1643.3 | -3.0 | 1.020 | 1.020 | 2.827 | HCC1806 KIN001-244 0 2 72 |
| HCC70 | Alpelisib | 2 | 72 | 0.32 | 2573.5 | 2514.5 | 722.8 | -0.495 | 1.030 | 1.020 | 1.799 | HCC70 BYL719 0 2 72 |
| HCC1806 | GDC-0980 | 2 | 72 | 0.001 | 11516.0 | 11293.0 | 1643.3 | -3.0 | 1.010 | 1.020 | 2.781 | HCC1806 GDC0980 0 2 72 |
| HCC1806 | AZD-6482 | 2 | 72 | 3.2 | 11967.3 | 11709.8 | 1643.3 | 0.505 | 1.020 | 1.020 | 2.833 | HCC1806 AZD6482 0 2 72 |
| BT-20 | PI103 | 3 | 72 | 0.032 | 3367.3 | 3311.5 | 586.9 | -1.49 | 1.010 | 1.020 | 2.496 | BT20 PI103 0 3 |
| HCC38 | CAL-101 | 2 | 72 | 0.032 | 3149.8 | 3073.0 | 690.5 | -1.49 | 1.020 | 1.020 | 2.154 | HCC38 CAL101 0 2 72 |
| HCC1806 | TGX221 | 2 | 72 | 0.032 | 11433.8 | 11158.5 | 1643.3 | -1.49 | 1.020 | 1.020 | 2.763 | HCC1806 TGX221 0 2 72 |
| HCC1806 | ZSTK474 | 2 | 72 | 0.01 | 11648.8 | 11395.8 | 1643.3 | -2.0 | 1.020 | 1.020 | 2.794 | HCC1806 ZSTK474 0 2 72 |
| HCC38 | CAL-101 | 1 | 72 | 0.01 | 4368.3 | 4275.5 | 1295.5 | -2.0 | 1.030 | 1.020 | 1.723 | HCC38 CAL101 0 1 72 |
| HCC38 | TGX221 | 1 | 72 | 0.001 | 4377.5 | 4281.3 | 1295.5 | -3.0 | 1.030 | 1.020 | 1.724 | HCC38 TGX221 0 1 72 |
| HCC38 | AS605240 | 2 | 72 | 0.0032 | 3249.3 | 3173.5 | 690.5 | -2.49 | 1.020 | 1.020 | 2.200 | HCC38 AS605240 0 2 72 |
| HCC70 | KIN001-244 | 3 | 72 | 0.1 | 2917.3 | 2870.0 | 517.3 | -1.0 | 1.010 | 1.020 | 2.472 | HCC70 KIN001-244 0 3 72 |
| HCC70 | XL147 | 1 | 72 | 0.01 | 3449.5 | 3367.3 | 1279.8 | -2.0 | 1.030 | 1.020 | 1.396 | HCC70 XL147 0 1 72 |
| HCC70 | BX-912 | 2 | 72 | 0.32 | 2383.0 | 2337.5 | 722.8 | -0.495 | 1.020 | 1.020 | 1.693 | HCC70 BX912 0 2 72 |
| BT-20 | TGX221 | 1 | 72 | 3.2 | 5857.5 | 5723.8 | 1443.3 | 0.505 | 1.020 | 1.020 | 1.988 | BT20 TGX221 0 1 |
| BT-20 | TGX221 | 1 | 72 | 1.0 | 5819.3 | 5723.8 | 1443.3 | 0.0 | 1.020 | 1.020 | 1.988 | BT20 TGX221 0 1 |
| BT-20 | TGX221 | 1 | 72 | 0.32 | 5838.0 | 5723.8 | 1443.3 | -0.495 | 1.020 | 1.020 | 1.988 | BT20 TGX221 0 1 |
| HCC70 | PI103 | 2 | 72 | 0.0032 | 2457.8 | 2413.0 | 722.8 | -2.49 | 1.020 | 1.020 | 1.739 | HCC70 PI103 0 2 72 |
| BT-20 | TGX221 | 1 | 72 | 0.1 | 5830.8 | 5723.8 | 1443.3 | -1.0 | 1.020 | 1.020 | 1.988 | BT20 TGX221 0 1 |
| HCC70 | GDC-0980 | 1 | 72 | 0.01 | 3329.8 | 3261.8 | 1279.8 | -2.0 | 1.030 | 1.020 | 1.350 | HCC70 GDC0980 0 1 72 |
| HCC1806 | AZD-6482 | 2 | 72 | 0.032 | 11940.3 | 11709.8 | 1643.3 | -1.49 | 1.010 | 1.020 | 2.833 | HCC1806 AZD6482 0 2 72 |
| HCC1806 | ZSTK474 | 1 | 72 | 0.01 | 11648.8 | 11395.8 | 1742.8 | -2.0 | 1.020 | 1.020 | 2.709 | HCC1806 ZSTK474 0 1 72 |
| HCC1806 | ZSTK474 | 1 | 72 | 0.0032 | 11595.8 | 11395.8 | 1742.8 | -2.49 | 1.010 | 1.020 | 2.709 | HCC1806 ZSTK474 0 1 72 |