Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | XL147 | 3 | 72 | 0.1 | 4330.0 | 4203.0 | 571.3 | -1.0 | 1.020 | 1.030 | 2.879 | Hs578T XL147 3 |
| Hs 578T | XL147 | 3 | 72 | 0.32 | 4162.5 | 4203.0 | 571.3 | -0.495 | 0.993 | 0.990 | 2.879 | Hs578T XL147 3 |
| Hs 578T | XL147 | 3 | 72 | 3.2 | 4031.5 | 4203.0 | 571.3 | 0.505 | 0.971 | 0.959 | 2.879 | Hs578T XL147 3 |
| Hs 578T | XL147 | 3 | 72 | 0.01 | 4398.8 | 4203.0 | 571.3 | -2.0 | 1.030 | 1.050 | 2.879 | Hs578T XL147 3 |
| Hs 578T | XL147 | 3 | 72 | 0.0032 | 4271.5 | 4203.0 | 571.3 | -2.49 | 1.010 | 1.020 | 2.879 | Hs578T XL147 3 |
| Hs 578T | XL147 | 3 | 72 | 0.032 | 4383.0 | 4203.0 | 571.3 | -1.49 | 1.030 | 1.040 | 2.879 | Hs578T XL147 3 |
| Hs 578T | XL147 | 3 | 72 | 0.001 | 4128.5 | 4203.0 | 571.3 | -3.0 | 0.988 | 0.982 | 2.879 | Hs578T XL147 3 |
| Hs 578T | XL147 | 2 | 72 | 3.2 | 3449.5 | 3556.8 | 624.7 | 0.505 | 0.976 | 0.970 | 2.509 | Hs578T XL147 2 |
| Hs 578T | XL147 | 2 | 72 | 0.032 | 3605.5 | 3556.8 | 624.7 | -1.49 | 1.010 | 1.010 | 2.509 | Hs578T XL147 2 |
| Hs 578T | XL147 | 2 | 72 | 0.1 | 3594.0 | 3556.8 | 624.7 | -1.0 | 1.010 | 1.010 | 2.509 | Hs578T XL147 2 |
| Hs 578T | XL147 | 2 | 72 | 0.32 | 3631.0 | 3556.8 | 624.7 | -0.495 | 1.020 | 1.020 | 2.509 | Hs578T XL147 2 |
| Hs 578T | XL147 | 2 | 72 | 0.001 | 3450.8 | 3556.8 | 624.7 | -3.0 | 0.976 | 0.970 | 2.509 | Hs578T XL147 2 |
| Hs 578T | XL147 | 2 | 72 | 0.0032 | 3536.3 | 3556.8 | 624.7 | -2.49 | 0.995 | 0.994 | 2.509 | Hs578T XL147 2 |
| Hs 578T | XL147 | 2 | 72 | 1.0 | 3462.3 | 3556.8 | 624.7 | 0.0 | 0.979 | 0.973 | 2.509 | Hs578T XL147 2 |
| Hs 578T | XL147 | 2 | 72 | 0.01 | 3614.3 | 3556.8 | 624.7 | -2.0 | 1.010 | 1.020 | 2.509 | Hs578T XL147 2 |
| Hs 578T | XL147 | 1 | 72 | 0.32 | 3396.3 | 3524.5 | 873.1 | -0.495 | 0.964 | 0.964 | 2.013 | Hs578T XL147 1 |
| Hs 578T | XL147 | 1 | 72 | 1.0 | 3408.8 | 3524.5 | 873.1 | 0.0 | 0.967 | 0.967 | 2.013 | Hs578T XL147 1 |
| Hs 578T | XL147 | 1 | 72 | 0.01 | 3634.8 | 3524.5 | 873.1 | -2.0 | 1.030 | 1.030 | 2.013 | Hs578T XL147 1 |
| Hs 578T | XL147 | 1 | 72 | 0.032 | 3640.8 | 3524.5 | 873.1 | -1.49 | 1.030 | 1.030 | 2.013 | Hs578T XL147 1 |
| Hs 578T | XL147 | 1 | 72 | 0.0032 | 3642.0 | 3524.5 | 873.1 | -2.49 | 1.030 | 1.030 | 2.013 | Hs578T XL147 1 |
| Hs 578T | XL147 | 1 | 72 | 3.2 | 3463.8 | 3524.5 | 873.1 | 0.505 | 0.983 | 0.983 | 2.013 | Hs578T XL147 1 |
| Hs 578T | XL147 | 1 | 72 | 0.1 | 3484.3 | 3524.5 | 873.1 | -1.0 | 0.989 | 0.989 | 2.013 | Hs578T XL147 1 |
| Hs 578T | XL147 | 1 | 72 | 0.001 | 3279.5 | 3524.5 | 873.1 | -3.0 | 0.930 | 0.930 | 2.013 | Hs578T XL147 1 |
| Hs 578T | WYE-125132 | 3 | 72 | 0.1 | 1489.8 | 4195.3 | 571.3 | -1.0 | 0.395 | 0.355 | 2.876 | Hs578T WYE125132 3 |
| Hs 578T | WYE-125132 | 3 | 72 | 0.032 | 2208.3 | 4195.3 | 571.3 | -1.49 | 0.600 | 0.526 | 2.876 | Hs578T WYE125132 3 |