Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | Everolimus | 1 | 72 | 3.2 | 8863.5 | 12020.5 | 1742.8 | 0.505 | 0.793 | 0.737 | 2.786 | HCC1806 Everolimus 0 1 72 |
| HCC1806 | Pictilisib | 1 | 72 | 0.001 | 11432.3 | 11984.0 | 1742.8 | -3.0 | 0.966 | 0.954 | 2.782 | HCC1806 GDC0941 0 1 72 |
| HCC1806 | Pictilisib | 1 | 72 | 0.0032 | 11408.5 | 11984.0 | 1742.8 | -2.49 | 0.965 | 0.952 | 2.782 | HCC1806 GDC0941 0 1 72 |
| HCC1806 | Pictilisib | 1 | 72 | 0.01 | 11154.5 | 11984.0 | 1742.8 | -2.0 | 0.949 | 0.931 | 2.782 | HCC1806 GDC0941 0 1 72 |
| HCC1806 | Pictilisib | 1 | 72 | 0.032 | 11917.8 | 11984.0 | 1742.8 | -1.49 | 0.996 | 0.994 | 2.782 | HCC1806 GDC0941 0 1 72 |
| HCC1806 | Pictilisib | 1 | 72 | 0.1 | 11495.5 | 11984.0 | 1742.8 | -1.0 | 0.970 | 0.959 | 2.782 | HCC1806 GDC0941 0 1 72 |
| HCC1806 | Pictilisib | 1 | 72 | 0.32 | 11380.8 | 11984.0 | 1742.8 | -0.495 | 0.963 | 0.950 | 2.782 | HCC1806 GDC0941 0 1 72 |
| HCC1806 | Pictilisib | 1 | 72 | 1.0 | 10951.3 | 11984.0 | 1742.8 | 0.0 | 0.936 | 0.914 | 2.782 | HCC1806 GDC0941 0 1 72 |
| HCC1806 | Pictilisib | 1 | 72 | 3.2 | 8798.5 | 11984.0 | 1742.8 | 0.505 | 0.790 | 0.734 | 2.782 | HCC1806 GDC0941 0 1 72 |
| HCC1806 | GDC-0980 | 1 | 72 | 0.001 | 11516.0 | 11293.0 | 1742.8 | -3.0 | 1.010 | 1.020 | 2.696 | HCC1806 GDC0980 0 1 72 |
| HCC1806 | GDC-0980 | 1 | 72 | 0.0032 | 11217.3 | 11293.0 | 1742.8 | -2.49 | 0.995 | 0.993 | 2.696 | HCC1806 GDC0980 0 1 72 |
| HCC1806 | GDC-0980 | 1 | 72 | 0.01 | 11207.3 | 11293.0 | 1742.8 | -2.0 | 0.994 | 0.992 | 2.696 | HCC1806 GDC0980 0 1 72 |
| HCC1806 | GDC-0980 | 1 | 72 | 0.032 | 11461.8 | 11293.0 | 1742.8 | -1.49 | 1.010 | 1.010 | 2.696 | HCC1806 GDC0980 0 1 72 |
| HCC1806 | GDC-0980 | 1 | 72 | 0.1 | 10419.3 | 11293.0 | 1742.8 | -1.0 | 0.941 | 0.923 | 2.696 | HCC1806 GDC0980 0 1 72 |
| HCC1806 | GDC-0980 | 1 | 72 | 0.32 | 7985.5 | 11293.0 | 1742.8 | -0.495 | 0.759 | 0.707 | 2.696 | HCC1806 GDC0980 0 1 72 |
| HCC1806 | GDC-0980 | 1 | 72 | 1.0 | 5800.0 | 11293.0 | 1742.8 | 0.0 | 0.562 | 0.514 | 2.696 | HCC1806 GDC0980 0 1 72 |
| HCC1806 | GDC-0980 | 1 | 72 | 3.2 | 3828.3 | 11293.0 | 1742.8 | 0.505 | 0.339 | 0.339 | 2.696 | HCC1806 GDC0980 0 1 72 |
| HCC1806 | Omipalisib | 1 | 72 | 0.001 | 10878.5 | 11840.0 | 1742.8 | -3.0 | 0.940 | 0.919 | 2.764 | HCC1806 GSK458 0 1 72 |
| HCC1806 | Omipalisib | 1 | 72 | 0.0032 | 11552.0 | 11840.0 | 1742.8 | -2.49 | 0.982 | 0.976 | 2.764 | HCC1806 GSK458 0 1 72 |
| HCC1806 | Omipalisib | 1 | 72 | 0.01 | 10689.3 | 11840.0 | 1742.8 | -2.0 | 0.927 | 0.903 | 2.764 | HCC1806 GSK458 0 1 72 |
| HCC1806 | Omipalisib | 1 | 72 | 0.032 | 7012.3 | 11840.0 | 1742.8 | -1.49 | 0.655 | 0.592 | 2.764 | HCC1806 GSK458 0 1 72 |
| HCC1806 | Omipalisib | 1 | 72 | 0.1 | 4476.3 | 11840.0 | 1742.8 | -1.0 | 0.407 | 0.378 | 2.764 | HCC1806 GSK458 0 1 72 |
| HCC1806 | Omipalisib | 1 | 72 | 0.32 | 3470.8 | 11840.0 | 1742.8 | -0.495 | 0.283 | 0.293 | 2.764 | HCC1806 GSK458 0 1 72 |
| HCC1806 | Omipalisib | 1 | 72 | 1.0 | 1813.3 | 11840.0 | 1742.8 | 0.0 | 0.014 | 0.153 | 2.764 | HCC1806 GSK458 0 1 72 |
| HCC1806 | Omipalisib | 1 | 72 | 3.2 | 569.3 | 11840.0 | 1742.8 | 0.505 | -0.333 | 0.048 | 2.764 | HCC1806 GSK458 0 1 72 |