Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | Torin1 | 1 | 72 | 0.032 | 2393.3 | 3250.8 | 1279.8 | -1.49 | 0.593 | 0.736 | 1.345 | HCC70 Torin1 0 1 72 |
| HCC70 | Torin1 | 1 | 72 | 0.1 | 2067.3 | 3250.8 | 1279.8 | -1.0 | 0.428 | 0.636 | 1.345 | HCC70 Torin1 0 1 72 |
| HCC70 | Torin1 | 1 | 72 | 0.32 | 1648.5 | 3250.8 | 1279.8 | -0.495 | 0.207 | 0.507 | 1.345 | HCC70 Torin1 0 1 72 |
| HCC70 | Torin1 | 1 | 72 | 1.0 | 1545.0 | 3250.8 | 1279.8 | 0.0 | 0.150 | 0.475 | 1.345 | HCC70 Torin1 0 1 72 |
| HCC70 | Torin1 | 1 | 72 | 3.2 | 1655.5 | 3250.8 | 1279.8 | 0.505 | 0.211 | 0.509 | 1.345 | HCC70 Torin1 0 1 72 |
| HCC70 | Torin2 | 1 | 72 | 0.001 | 3100.0 | 3294.3 | 1279.8 | -3.0 | 0.913 | 0.941 | 1.364 | HCC70 Torin2 0 1 72 |
| HCC70 | Torin2 | 1 | 72 | 0.0032 | 2749.5 | 3294.3 | 1279.8 | -2.49 | 0.752 | 0.835 | 1.364 | HCC70 Torin2 0 1 72 |
| HCC70 | Torin2 | 1 | 72 | 0.01 | 2597.5 | 3294.3 | 1279.8 | -2.0 | 0.680 | 0.788 | 1.364 | HCC70 Torin2 0 1 72 |
| HCC70 | Torin2 | 1 | 72 | 0.032 | 2134.3 | 3294.3 | 1279.8 | -1.49 | 0.455 | 0.648 | 1.364 | HCC70 Torin2 0 1 72 |
| HCC70 | Torin2 | 1 | 72 | 0.1 | 1809.5 | 3294.3 | 1279.8 | -1.0 | 0.289 | 0.549 | 1.364 | HCC70 Torin2 0 1 72 |
| HCC70 | Torin2 | 1 | 72 | 0.32 | 957.5 | 3294.3 | 1279.8 | -0.495 | -0.192 | 0.291 | 1.364 | HCC70 Torin2 0 1 72 |
| HCC70 | Torin2 | 1 | 72 | 1.0 | 526.5 | 3294.3 | 1279.8 | 0.0 | -0.479 | 0.160 | 1.364 | HCC70 Torin2 0 1 72 |
| HCC70 | Torin2 | 1 | 72 | 3.2 | 212.0 | 3294.3 | 1279.8 | 0.505 | -0.732 | 0.064 | 1.364 | HCC70 Torin2 0 1 72 |
| HCC70 | Trametinib | 1 | 72 | 0.001 | 3041.3 | 3427.3 | 1279.8 | -3.0 | 0.839 | 0.887 | 1.421 | HCC70 Trametinib 0 1 72 |
| HCC70 | Trametinib | 1 | 72 | 0.0032 | 2779.5 | 3427.3 | 1279.8 | -2.49 | 0.726 | 0.811 | 1.421 | HCC70 Trametinib 0 1 72 |
| HCC70 | Trametinib | 1 | 72 | 0.01 | 2320.3 | 3427.3 | 1279.8 | -2.0 | 0.520 | 0.677 | 1.421 | HCC70 Trametinib 0 1 72 |
| HCC70 | Trametinib | 1 | 72 | 0.032 | 2250.5 | 3427.3 | 1279.8 | -1.49 | 0.488 | 0.657 | 1.421 | HCC70 Trametinib 0 1 72 |
| HCC70 | Trametinib | 1 | 72 | 0.1 | 1891.0 | 3427.3 | 1279.8 | -1.0 | 0.316 | 0.552 | 1.421 | HCC70 Trametinib 0 1 72 |
| HCC70 | Trametinib | 1 | 72 | 0.32 | 1968.0 | 3427.3 | 1279.8 | -0.495 | 0.354 | 0.574 | 1.421 | HCC70 Trametinib 0 1 72 |
| HCC70 | Trametinib | 1 | 72 | 1.0 | 1938.3 | 3427.3 | 1279.8 | 0.0 | 0.339 | 0.566 | 1.421 | HCC70 Trametinib 0 1 72 |
| HCC70 | Trametinib | 1 | 72 | 3.2 | 2009.0 | 3427.3 | 1279.8 | 0.505 | 0.373 | 0.586 | 1.421 | HCC70 Trametinib 0 1 72 |
| HCC70 | WYE-125132 | 1 | 72 | 0.001 | 3120.8 | 3334.5 | 1279.8 | -3.0 | 0.906 | 0.936 | 1.382 | HCC70 WYE125132 0 1 72 |
| HCC70 | WYE-125132 | 1 | 72 | 0.0032 | 3184.5 | 3334.5 | 1279.8 | -2.49 | 0.934 | 0.955 | 1.382 | HCC70 WYE125132 0 1 72 |
| HCC70 | WYE-125132 | 1 | 72 | 0.01 | 2861.0 | 3334.5 | 1279.8 | -2.0 | 0.790 | 0.858 | 1.382 | HCC70 WYE125132 0 1 72 |
| HCC70 | WYE-125132 | 1 | 72 | 0.032 | 2333.3 | 3334.5 | 1279.8 | -1.49 | 0.544 | 0.700 | 1.382 | HCC70 WYE125132 0 1 72 |