Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | WYE-125132 | 1 | 72 | 0.32 | 1730.5 | 4231.5 | 1295.5 | -0.495 | 0.185 | 0.409 | 1.708 | HCC38 WYE125132 0 1 72 |
| HCC38 | WYE-125132 | 1 | 72 | 1.0 | 1629.0 | 4231.5 | 1295.5 | 0.0 | 0.144 | 0.385 | 1.708 | HCC38 WYE125132 0 1 72 |
| HCC38 | WYE-125132 | 1 | 72 | 3.2 | 1624.3 | 4231.5 | 1295.5 | 0.505 | 0.142 | 0.384 | 1.708 | HCC38 WYE125132 0 1 72 |
| HCC38 | XL147 | 1 | 72 | 0.001 | 4140.8 | 4362.8 | 1295.5 | -3.0 | 0.941 | 0.949 | 1.752 | HCC38 XL147 0 1 72 |
| HCC38 | XL147 | 1 | 72 | 0.0032 | 4326.5 | 4362.8 | 1295.5 | -2.49 | 0.990 | 0.992 | 1.752 | HCC38 XL147 0 1 72 |
| HCC38 | XL147 | 1 | 72 | 0.01 | 4253.5 | 4362.8 | 1295.5 | -2.0 | 0.971 | 0.975 | 1.752 | HCC38 XL147 0 1 72 |
| HCC38 | XL147 | 1 | 72 | 0.032 | 4278.3 | 4362.8 | 1295.5 | -1.49 | 0.978 | 0.981 | 1.752 | HCC38 XL147 0 1 72 |
| HCC38 | XL147 | 1 | 72 | 0.1 | 4418.0 | 4362.8 | 1295.5 | -1.0 | 1.010 | 1.010 | 1.752 | HCC38 XL147 0 1 72 |
| HCC38 | XL147 | 1 | 72 | 0.32 | 4187.3 | 4362.8 | 1295.5 | -0.495 | 0.954 | 0.960 | 1.752 | HCC38 XL147 0 1 72 |
| HCC38 | XL147 | 1 | 72 | 1.0 | 4168.0 | 4362.8 | 1295.5 | 0.0 | 0.949 | 0.955 | 1.752 | HCC38 XL147 0 1 72 |
| HCC38 | XL147 | 1 | 72 | 3.2 | 4313.0 | 4362.8 | 1295.5 | 0.505 | 0.987 | 0.989 | 1.752 | HCC38 XL147 0 1 72 |
| HCC38 | ZSTK474 | 1 | 72 | 0.001 | 4237.8 | 4334.5 | 1295.5 | -3.0 | 0.974 | 0.978 | 1.742 | HCC38 ZSTK474 0 1 72 |
| HCC38 | ZSTK474 | 1 | 72 | 0.0032 | 4297.0 | 4334.5 | 1295.5 | -2.49 | 0.990 | 0.991 | 1.742 | HCC38 ZSTK474 0 1 72 |
| HCC38 | ZSTK474 | 1 | 72 | 0.01 | 4395.8 | 4334.5 | 1295.5 | -2.0 | 1.020 | 1.010 | 1.742 | HCC38 ZSTK474 0 1 72 |
| HCC38 | ZSTK474 | 1 | 72 | 0.032 | 4233.3 | 4334.5 | 1295.5 | -1.49 | 0.973 | 0.977 | 1.742 | HCC38 ZSTK474 0 1 72 |
| HCC38 | ZSTK474 | 1 | 72 | 0.1 | 4065.8 | 4334.5 | 1295.5 | -1.0 | 0.928 | 0.938 | 1.742 | HCC38 ZSTK474 0 1 72 |
| HCC38 | ZSTK474 | 1 | 72 | 0.32 | 3576.3 | 4334.5 | 1295.5 | -0.495 | 0.791 | 0.825 | 1.742 | HCC38 ZSTK474 0 1 72 |
| HCC38 | ZSTK474 | 1 | 72 | 1.0 | 3154.3 | 4334.5 | 1295.5 | 0.0 | 0.666 | 0.728 | 1.742 | HCC38 ZSTK474 0 1 72 |
| HCC38 | ZSTK474 | 1 | 72 | 3.2 | 2494.0 | 4334.5 | 1295.5 | 0.505 | 0.456 | 0.575 | 1.742 | HCC38 ZSTK474 0 1 72 |
| HCC38 | AS605240 | 2 | 72 | 0.001 | 2978.5 | 3173.5 | 690.5 | -3.0 | 0.943 | 0.939 | 2.200 | HCC38 AS605240 0 2 72 |
| HCC38 | AS605240 | 2 | 72 | 0.0032 | 3249.3 | 3173.5 | 690.5 | -2.49 | 1.020 | 1.020 | 2.200 | HCC38 AS605240 0 2 72 |
| HCC38 | AS605240 | 2 | 72 | 0.01 | 3011.8 | 3173.5 | 690.5 | -2.0 | 0.953 | 0.949 | 2.200 | HCC38 AS605240 0 2 72 |
| HCC38 | AS605240 | 2 | 72 | 0.032 | 3030.0 | 3173.5 | 690.5 | -1.49 | 0.958 | 0.955 | 2.200 | HCC38 AS605240 0 2 72 |
| HCC38 | AS605240 | 2 | 72 | 0.1 | 2827.5 | 3173.5 | 690.5 | -1.0 | 0.898 | 0.891 | 2.200 | HCC38 AS605240 0 2 72 |
| HCC38 | AS605240 | 2 | 72 | 0.32 | 2502.5 | 3173.5 | 690.5 | -0.495 | 0.795 | 0.789 | 2.200 | HCC38 AS605240 0 2 72 |