Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | TGX221 | 3 | 72 | 0.0032 | 11187.8 | 11158.5 | 1273.3 | -2.49 | 1.000 | 1.000 | 3.132 | HCC1806 TGX221 0 3 72 |
| HCC1806 | TGX221 | 3 | 72 | 0.01 | 11230.5 | 11158.5 | 1273.3 | -2.0 | 1.000 | 1.010 | 3.132 | HCC1806 TGX221 0 3 72 |
| HCC1806 | TGX221 | 3 | 72 | 0.032 | 11433.8 | 11158.5 | 1273.3 | -1.49 | 1.020 | 1.020 | 3.132 | HCC1806 TGX221 0 3 72 |
| HCC1806 | TGX221 | 3 | 72 | 0.1 | 11446.3 | 11158.5 | 1273.3 | -1.0 | 1.020 | 1.030 | 3.132 | HCC1806 TGX221 0 3 72 |
| HCC1806 | TGX221 | 3 | 72 | 0.32 | 11531.3 | 11158.5 | 1273.3 | -0.495 | 1.020 | 1.030 | 3.132 | HCC1806 TGX221 0 3 72 |
| HCC1806 | TGX221 | 3 | 72 | 1.0 | 11205.8 | 11158.5 | 1273.3 | 0.0 | 1.000 | 1.000 | 3.132 | HCC1806 TGX221 0 3 72 |
| HCC1806 | TGX221 | 3 | 72 | 3.2 | 11540.3 | 11158.5 | 1273.3 | 0.505 | 1.020 | 1.030 | 3.132 | HCC1806 TGX221 0 3 72 |
| HCC1806 | Torin1 | 3 | 72 | 0.001 | 11438.8 | 11764.8 | 1273.3 | -3.0 | 0.983 | 0.972 | 3.208 | HCC1806 Torin1 0 3 72 |
| HCC1806 | Torin1 | 3 | 72 | 0.0032 | 11138.3 | 11764.8 | 1273.3 | -2.49 | 0.966 | 0.947 | 3.208 | HCC1806 Torin1 0 3 72 |
| HCC1806 | Torin1 | 3 | 72 | 0.01 | 9981.5 | 11764.8 | 1273.3 | -2.0 | 0.900 | 0.848 | 3.208 | HCC1806 Torin1 0 3 72 |
| HCC1806 | Torin1 | 3 | 72 | 0.032 | 8862.3 | 11764.8 | 1273.3 | -1.49 | 0.831 | 0.753 | 3.208 | HCC1806 Torin1 0 3 72 |
| HCC1806 | Torin1 | 3 | 72 | 0.1 | 6527.8 | 11764.8 | 1273.3 | -1.0 | 0.664 | 0.555 | 3.208 | HCC1806 Torin1 0 3 72 |
| HCC1806 | Torin1 | 3 | 72 | 0.32 | 5149.3 | 11764.8 | 1273.3 | -0.495 | 0.546 | 0.438 | 3.208 | HCC1806 Torin1 0 3 72 |
| HCC1806 | Torin1 | 3 | 72 | 1.0 | 4599.5 | 11764.8 | 1273.3 | 0.0 | 0.492 | 0.391 | 3.208 | HCC1806 Torin1 0 3 72 |
| HCC1806 | Torin1 | 3 | 72 | 3.2 | 3197.0 | 11764.8 | 1273.3 | 0.505 | 0.332 | 0.272 | 3.208 | HCC1806 Torin1 0 3 72 |
| HCC1806 | Torin2 | 3 | 72 | 0.001 | 11442.3 | 11795.0 | 1273.3 | -3.0 | 0.981 | 0.970 | 3.212 | HCC1806 Torin2 0 3 72 |
| HCC1806 | Torin2 | 3 | 72 | 0.0032 | 11163.3 | 11795.0 | 1273.3 | -2.49 | 0.966 | 0.946 | 3.212 | HCC1806 Torin2 0 3 72 |
| HCC1806 | Torin2 | 3 | 72 | 0.01 | 9689.3 | 11795.0 | 1273.3 | -2.0 | 0.881 | 0.821 | 3.212 | HCC1806 Torin2 0 3 72 |
| HCC1806 | Torin2 | 3 | 72 | 0.032 | 7731.3 | 11795.0 | 1273.3 | -1.49 | 0.754 | 0.655 | 3.212 | HCC1806 Torin2 0 3 72 |
| HCC1806 | Torin2 | 3 | 72 | 0.1 | 3607.0 | 11795.0 | 1273.3 | -1.0 | 0.383 | 0.306 | 3.212 | HCC1806 Torin2 0 3 72 |
| HCC1806 | Torin2 | 3 | 72 | 0.32 | 1227.5 | 11795.0 | 1273.3 | -0.495 | -0.011 | 0.104 | 3.212 | HCC1806 Torin2 0 3 72 |
| HCC1806 | Torin2 | 3 | 72 | 1.0 | 999.5 | 11795.0 | 1273.3 | 0.0 | -0.073 | 0.085 | 3.212 | HCC1806 Torin2 0 3 72 |
| HCC1806 | Torin2 | 3 | 72 | 3.2 | 931.5 | 11795.0 | 1273.3 | 0.505 | -0.093 | 0.079 | 3.212 | HCC1806 Torin2 0 3 72 |
| HCC1806 | Trametinib | 3 | 72 | 0.001 | 11633.3 | 11736.5 | 1273.3 | -3.0 | 0.994 | 0.991 | 3.204 | HCC1806 Trametinib 0 3 72 |
| HCC1806 | Trametinib | 3 | 72 | 0.0032 | 10675.8 | 11736.5 | 1273.3 | -2.49 | 0.942 | 0.910 | 3.204 | HCC1806 Trametinib 0 3 72 |