Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| BT-549 | AZD5363 | 43.7006769506 | 0.4943 | 0.2130 | 1000.0000 | -0.4263 | 0.1970 | 0.7620 | 1.61378319596e-08 |
| BT-549 | AZD6738 | 3.78928346904 | -0.1598 | 0.0782 | 5.9672 | -0.5898 | 1.7158 | 0.9614 | 1.11022302463e-16 |
| BT-549 | BMS-265246 | 0.000876906453272 | -0.1682 | 0.9458 | 0.0017 | -0.1811 | 0.4642 | 0.9714 | 1.11022302463e-16 |
| BT-549 | Ulixertinib | 14.0227864348 | 0.4913 | 0.1080 | 138.8541 | -1.0000 | 0.4792 | 0.8946 | 6.09512440519e-13 |
| BT-549 | Alvocidib | 0.161331919984 | -0.4334 | 0.2463 | 0.3134 | -0.7128 | 1.3342 | 0.9894 | 1.11022302463e-16 |
| BT-549 | GSK2334470 | 39.8431993112 | 0.6627 | 0.0914 | 431.7005 | -1.0000 | 0.4611 | 0.6922 | 4.01254562132e-07 |
| BT-549 | Ribociclib | inf | 0.9258 | 0.0097 | 0.0000 | 0.9885 | 0.0100 | 0.0000 | 0.489440623384 |
| BT-549 | LY3023414 | 0.000704789836999 | -0.4244 | 0.7781 | 1.5836 | -0.9316 | 0.1363 | 0.8143 | 7.2423111952e-10 |
| BT-549 | RO-3306 | -inf | -0.1143 | ||||||
| BT-549 | Rucaparib | inf | 0.8808 | 0.0404 | 0.0000 | 0.9550 | 0.0100 | 0.0000 | 1.0 |
| BT-549 | SHP099 | 2619.73295091 | 0.8306 | 0.0279 | 21.5161 | 0.4877 | 0.7710 | 0.6498 | 2.01339374906e-06 |
| BT-549 | THZ1 | 0.0507973383595 | -0.4458 | 0.3738 | 0.0826 | -0.4271 | 1.2714 | 0.9715 | 1.11022302463e-16 |
| BT-549 | THZ531 | 0.288722955947 | -0.3189 | 0.1797 | 0.5487 | -0.8192 | 1.5112 | 0.9852 | 1.11022302463e-16 |
| BT-549 | Senexin B | 598505.801069 | 0.6142 | 0.1855 | 1.2265 | 0.4833 | 0.2593 | 0.6553 | 1.65276736008e-06 |
| HCC1806 | MK 1775 | 0.0128166062504 | -0.4617 | 0.8151 | 0.0380 | -0.4095 | 0.5503 | 0.9684 | 1.11022302463e-16 |
| HCC1806 | AZD2014 | 1.79837045193 | 0.3811 | 0.3438 | 2.3555 | -0.0311 | 0.2238 | 0.8823 | 2.43538522682e-12 |
| HCC1806 | AZD5363 | 1097.05246074 | 0.6869 | 0.0528 | 1000.0000 | 0.0138 | 0.3031 | 0.3511 | 0.00448557172627 |
| HCC1806 | AZD6738 | 1.14078689634 | -0.2827 | 0.2797 | 3.6562 | -0.8273 | 0.8382 | 0.9812 | 1.11022302463e-16 |
| HCC1806 | BMS-265246 | -inf | -0.0075 | ||||||
| HCC1806 | Ulixertinib | 37.8339826121 | 0.7126 | 0.0346 | 196.9739 | -1.0000 | 0.6659 | 0.6968 | 3.32864045105e-07 |
| HCC1806 | Alvocidib | 0.165238718298 | -0.4850 | 0.2588 | 0.4377 | -1.0000 | 1.1279 | 0.9859 | 1.11022302463e-16 |
| HCC1806 | GSK2334470 | 44.5159354048 | 0.8389 | 0.0198 | 86.1125 | -0.5419 | 1.1127 | 0.3134 | 0.00908806432112 |
| HCC1806 | Ribociclib | 168.232015049 | 0.6251 | 0.1419 | 317.3038 | -0.1285 | 0.3606 | 0.3213 | 0.00787309835959 |
| HCC1806 | LY3023414 | 0.347508533485 | -0.0312 | 0.4262 | 128.5881 | -1.0000 | 0.1858 | 0.6743 | 8.14403017468e-07 |
| HCC1806 | RO-3306 | 5.34198338119 | -0.1128 | 0.0801 | 5.6376 | -0.1545 | 5.0000 | 0.9818 | 1.11022302463e-16 |