Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-453 | Ulixertinib | 7.626205493 | 0.3905 | 0.0734 | 22.8576 | -1.0000 | 1.0008 | 0.7623 | 1.58e-08 |
| MDA-MB-453 | Alvocidib | 0.131746612 | -0.1949 | 0.2615 | 0.1512 | -0.1882 | 2.3212 | 0.9251 | 8.55e-15 |
| MDA-MB-453 | GSK2334470 | 2.045052119 | 0.1203 | 0.2628 | 36.8285 | -1.0000 | 0.3800 | 0.7865 | 4.15e-09 |
| MDA-MB-453 | Ribociclib | 0.036110625 | 0.1975 | 0.5328 | 0.0251 | 0.0538 | 0.3126 | 0.8276 | 2.86e-10 |
| MDA-MB-453 | LY3023414 | 0.000358181 | -0.6542 | 0.8640 | 0.5638 | -1.0000 | 0.1492 | 0.6094 | 7.89e-06 |
| MDA-MB-453 | RO-3306 | 5.832801693 | 0.0432 | 0.0980 | 10.4904 | -1.0000 | 1.8717 | 0.8565 | 2.89e-11 |
| MDA-MB-453 | Rucaparib | 6.427531839 | 0.1853 | 0.1565 | 12.4048 | -1.0000 | 1.6709 | 0.7065 | 2.21e-07 |
| MDA-MB-453 | Senexin B | 3.773643259 | 0.1441 | 0.1970 | 20.6751 | -1.0000 | 0.6459 | 0.6523 | 1.84e-06 |
| MDA-MB-453 | SHP099 | 11.54207272 | 0.7015 | 0.0178 | 14.3805 | -1.0000 | 4.9966 | 0.3055 | 0.010499523 |
| MDA-MB-453 | THZ1 | 0.01132408 | -0.3194 | 0.5368 | 0.0145 | -0.2023 | 1.3641 | 0.9524 | 1.11e-16 |
| MDA-MB-453 | THZ531 | 0.023156638 | -0.2594 | 0.5244 | 0.0292 | -0.3042 | 2.0411 | 0.9573 | 1.11e-16 |
| MDA-MB-468 | MK 1775 | 0.262235497 | -0.5155 | 0.4993 | 3.2089 | -1.0000 | 0.4387 | 0.8844 | 1.93e-12 |
| MDA-MB-468 | AZD2014 | 0.530882864 | 0.1867 | 0.3912 | 8.6918 | -0.5185 | 0.2545 | 0.9132 | 5.41e-14 |
| MDA-MB-468 | AZD5363 | 23.1790046 | 0.5103 | 0.1319 | 558.0456 | -1.0000 | 0.3453 | 0.7227 | 1.09e-07 |
| MDA-MB-468 | AZD6738 | 10.56189758 | 0.4777 | 0.0335 | 23.3227 | -0.9834 | 1.3728 | 0.7330 | 6.79e-08 |
| MDA-MB-468 | BMS-265246 | 0.129448207 | -0.1039 | 0.5150 | 7.7796 | -1.0000 | 0.2682 | 0.8711 | 7.57e-12 |
| MDA-MB-468 | Ulixertinib | 1.621194239 | 0.3429 | 0.2660 | 0.2539 | 0.3452 | 0.6324 | 0.9377 | 8.88e-16 |
| MDA-MB-468 | Alvocidib | 0.173077952 | -0.4235 | 0.2942 | 0.4622 | -0.9850 | 1.1084 | 0.9659 | 1.11e-16 |
| MDA-MB-468 | GSK2334470 | 10.51361506 | 0.4709 | 0.0792 | 20.7908 | -0.9912 | 1.6026 | 0.6636 | 1.22e-06 |
| MDA-MB-468 | Ribociclib | inf | 0.7972 | 0.0091 | 0.0000 | 0.9779 | 0.0100 | 0.0000 | 1.0 |
| MDA-MB-468 | LY3023414 | 0.012514366 | -0.2268 | 0.6656 | 5.3535 | -1.0000 | 0.1813 | 0.8899 | 1.05e-12 |
| MDA-MB-468 | RO-3306 | 4.552342144 | -0.3316 | 0.1790 | 7.7188 | -1.0000 | 2.0806 | 0.9133 | 5.33e-14 |
| MDA-MB-468 | Rucaparib | 8.561308874 | 0.3358 | 0.1029 | 13.5705 | -1.0000 | 2.3849 | 0.7696 | 1.08e-08 |
| MDA-MB-468 | Senexin B | 1.994645521 | 0.1170 | 0.2810 | 51.8931 | -1.0000 | 0.3371 | 0.8162 | 6.38e-10 |
| MDA-MB-468 | SHP099 | 15.69903996 | 0.5419 | 0.1218 | 54.5394 | -0.4817 | 0.5418 | 0.5522 | 4.35e-05 |