Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)

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Cell Small Molecule GR50 GRmax GR_AOC GEC50 GRinf GR Hill Coefficient GR r2 pval_GR
SUM159PT AZD6738
10.0174126
 0.4273 -0.0067 12.5628 -1.0000 4.8522 0.9120
6.41e-14
SUM159PT AZD5363
9.699048275
 0.4042 0.1679 240.6645 -1.0000 0.3421 0.9046
1.77e-13
SUM159PT AZD2014
0.175359057
 0.0970 0.4747 4.2801 -0.5797 0.2409 0.9735
1.11e-16
T47D THZ531
0.113575449
 -0.1534 0.2161 0.1189 -0.1295 5.0000 0.9624
1.11e-16
T47D AZD2014
3.57e-05
 -0.0845 0.9793 0.0001 -0.1251 0.2870 0.8093
1.01e-09
T47D AZD5363
0.013673243
 0.1402 0.6141 0.0075 0.1295 0.5033 0.9281
5.11e-15
T47D AZD6738
inf
 0.6619 -0.2131 0.0000 1.0000 0.0100 -0.9822
0.211726496
T47D BMS-265246
0.014946978
 -0.0154 0.6421 2.6347 -0.7862 0.1827 0.8936
6.85e-13
T47D Ulixertinib
3.528421043
 0.1952 0.2003 28.8265 -1.0000 0.5230 0.8600
2.12e-11
T47D Alvocidib
0.115068759
 -0.1548 0.2473 0.2275 -0.4346 0.9177 0.9066
1.35e-13
T47D GSK2334470
0.455522213
 0.1531 0.3958 0.9464 -0.1424 0.3428 0.9385
6.66e-16
T47D Ribociclib
-inf
 0.0709
T47D LY3023414
0.000116934
 -0.3084 0.9068 0.4558 -1.0000 0.1329 0.9366
1.11e-15
T47D RO-3306
7.208767727
 -0.0474 0.1168 9.9142 -1.0000 3.4475 0.8495
5.24e-11
T47D Rucaparib
inf
 0.8130 0.0415 0.0000 0.9307 0.0100 0.0000
0.073451061
T47D Senexin B
1.2300495
 0.1684 0.3222 54.5356 -1.0000 0.2897 0.9170
3.08e-14
T47D SHP099
inf
 0.6931 -0.0080 0.0000 0.9839 0.0100 0.0000
0.180531821
T47D THZ1
0.02898118
 -0.2718 0.4598 0.0353 -0.2278 1.8920 0.9732
1.11e-16
T47D MK 1775
5.03699179
 0.0963 0.1055 14.4307 -1.0000 1.0438 0.8167
6.18e-10