Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| BT-20 | AZD5363 | 1.72900360981 | 0.1717 | 0.3013 | 86.6237 | -1.0000 | 0.2807 | 0.8604 | 2.05393480002e-11 |
| BT-20 | MK 1775 | 1.80498033053 | -0.6583 | 0.2015 | 4.1869 | -1.0000 | 1.3057 | 0.9322 | 2.44249065418e-15 |
| BT-20 | AZD6738 | 5.68190940846 | 0.1069 | -0.0571 | 5.4098 | 0.1088 | 5.0000 | 0.8298 | 2.43821740575e-10 |
| BT-20 | THZ1 | 0.497469085347 | -0.4365 | 0.0947 | 0.7408 | -1.0000 | 2.7590 | 0.9734 | 1.11022302463e-16 |
| BT-20 | THZ531 | 1.39952715577 | 0.5663 | 0.0377 | 3.3807 | -1.0000 | 1.2457 | 0.6737 | 8.31588281125e-07 |
| BT-20 | BMS-265246 | 0.0017956253308 | -0.0805 | 0.8520 | 0.0041 | -0.1756 | 0.3616 | 0.9532 | 1.11022302463e-16 |
| BT-20 | Senexin B | 2.23064370113 | 0.0956 | 0.2772 | 71.2131 | -1.0000 | 0.3172 | 0.7918 | 3.02648173189e-09 |
| BT-549 | SHP099 | 2619.73295091 | 0.8306 | 0.0279 | 21.5161 | 0.4877 | 0.7710 | 0.6498 | 2.01339374906e-06 |
| BT-549 | THZ1 | 0.0507973383595 | -0.4458 | 0.3738 | 0.0826 | -0.4271 | 1.2714 | 0.9715 | 1.11022302463e-16 |
| BT-549 | Rucaparib | inf | 0.8808 | 0.0404 | 0.0000 | 0.9550 | 0.0100 | 0.0000 | 1.0 |
| BT-549 | THZ531 | 0.288722955947 | -0.3189 | 0.1797 | 0.5487 | -0.8192 | 1.5112 | 0.9852 | 1.11022302463e-16 |
| BT-549 | Ribociclib | inf | 0.9258 | 0.0097 | 0.0000 | 0.9885 | 0.0100 | 0.0000 | 0.489440623384 |
| BT-549 | LY3023414 | 0.000704789836999 | -0.4244 | 0.7781 | 1.5836 | -0.9316 | 0.1363 | 0.8143 | 7.2423111952e-10 |
| BT-549 | AZD2014 | 0.149914841094 | 0.0235 | 0.4823 | 23.5998 | -1.0000 | 0.2172 | 0.9241 | 1.01030295241e-14 |
| BT-549 | MK 1775 | 0.285141860039 | -0.4630 | 0.4365 | 2.2824 | -1.0000 | 0.5282 | 0.9608 | 1.11022302463e-16 |
| BT-549 | RO-3306 | -inf | -0.1143 | ||||||
| BT-549 | Senexin B | 598505.801069 | 0.6142 | 0.1855 | 1.2265 | 0.4833 | 0.2593 | 0.6553 | 1.65276736008e-06 |
| BT-549 | BMS-265246 | 0.000876906453272 | -0.1682 | 0.9458 | 0.0017 | -0.1811 | 0.4642 | 0.9714 | 1.11022302463e-16 |
| BT-549 | Ulixertinib | 14.0227864348 | 0.4913 | 0.1080 | 138.8541 | -1.0000 | 0.4792 | 0.8946 | 6.09512440519e-13 |
| BT-549 | AZD6738 | 3.78928346904 | -0.1598 | 0.0782 | 5.9672 | -0.5898 | 1.7158 | 0.9614 | 1.11022302463e-16 |
| BT-549 | Alvocidib | 0.161331919984 | -0.4334 | 0.2463 | 0.3134 | -0.7128 | 1.3342 | 0.9894 | 1.11022302463e-16 |
| BT-549 | AZD5363 | 43.7006769506 | 0.4943 | 0.2130 | 1000.0000 | -0.4263 | 0.1970 | 0.7620 | 1.61378319596e-08 |
| BT-549 | GSK2334470 | 39.8431993112 | 0.6627 | 0.0914 | 431.7005 | -1.0000 | 0.4611 | 0.6922 | 4.01254562132e-07 |
| CAL-120 | THZ1 | -inf | -0.1577 | ||||||
| CAL-120 | SHP099 | 13.63352074 | 0.7924 | 0.0042 | 16.9837 | -1.0000 | 5.0000 | 0.4392 | 0.000724955 |