Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| HCC38 | GSK2334470 | 362.2276812 | 0.7326 | 0.0411 | 1000.0000 | -0.2309 | 0.3738 | 0.3294 | 0.006774661 |
| HCC38 | Ribociclib | 0.517768611 | 0.2321 | 0.4237 | 305.2273 | -1.0000 | 0.1722 | 0.8460 | 6.98e-11 |
| HCC38 | LY3023414 | 0.003293109 | -0.0192 | 0.6632 | 57.0896 | -0.9609 | 0.1099 | 0.8238 | 3.77e-10 |
| HCC38 | RO-3306 | 7.435051917 | -0.2110 | 0.0493 | 9.2621 | -1.0000 | 5.0000 | 0.9513 | 1.11e-16 |
| HCC38 | Rucaparib | 3274.321387 | 0.6293 | 0.1296 | 1000.0000 | 0.1004 | 0.1890 | 0.3579 | 0.003936714 |
| HCC38 | Senexin B | 15.63810324 | 0.5236 | 0.1411 | 269.9088 | -0.9985 | 0.3853 | 0.5885 | 1.51e-05 |
| HCC70 | Senexin B | 16.531300381 | 0.4078 | 0.2194 | 1000.0000 | -0.7732 | 0.2278 | 0.4788 | 0.000290238214042 |
| HCC70 | MK 1775 | 0.000494343213706 | -0.7213 | 1.1390 | 0.0113 | -0.7848 | 0.3020 | 0.9292 | 4.21884749358e-15 |
| HCC70 | AZD2014 | 0.000212092429893 | 0.0222 | 0.7748 | 0.0025 | -0.2340 | 0.1552 | 0.8423 | 9.37158128878e-11 |
| HCC70 | AZD5363 | 0.0251705169742 | -0.2793 | 0.6653 | 0.5821 | -0.6722 | 0.2713 | 0.8708 | 7.80986386673e-12 |
| HCC70 | AZD6738 | 1.73555477677 | -0.5435 | 0.2705 | 4.4527 | -1.0000 | 1.1660 | 0.9336 | 1.88737914186e-15 |
| HCC70 | BMS-265246 | 0.00319357669583 | -0.1940 | 0.9108 | 0.0045 | -0.1529 | 0.7677 | 0.9705 | 1.11022302463e-16 |
| HCC70 | Ulixertinib | 1.412958526 | 0.3819 | 0.2819 | 0.0475 | 0.4787 | 0.9295 | 0.8473 | 6.27075058546e-11 |
| HCC70 | Alvocidib | 0.0750808131344 | -0.8534 | 0.4131 | 0.1347 | -0.9337 | 1.8026 | 0.9849 | 1.11022302463e-16 |
| HCC70 | GSK2334470 | 1.24076593852 | 0.1570 | 0.2931 | 2.9247 | -0.2245 | 0.4326 | 0.8858 | 1.66633373766e-12 |
| HCC70 | Ribociclib | inf | 1.0564 | -0.0040 | 0.0000 | 1.0000 | 0.0100 | -0.1699 | 1.0 |
| HCC70 | LY3023414 | 0.00246998519581 | -0.7413 | 0.7828 | 0.7825 | -1.0000 | 0.1908 | 0.6120 | 7.2607777184e-06 |
| HCC70 | RO-3306 | 4.56146799487 | -0.1657 | 0.1027 | 4.8784 | -0.1996 | 5.0000 | 0.9160 | 3.58602036954e-14 |
| HCC70 | Rucaparib | inf | 1.1144 | -0.0414 | 0.0000 | 1.0000 | 0.0100 | -0.1078 | 1.0 |
| HCC70 | SHP099 | 9764.61460436 | 0.6611 | 0.0633 | 4.4265 | 0.4969 | 0.6621 | 0.6369 | 3.16734529349e-06 |
| HCC70 | THZ1 | -inf | -0.8868 | ||||||
| HCC70 | THZ531 | 0.0645734883647 | -0.8397 | 0.4266 | 0.0849 | -0.7832 | 3.4505 | 0.9663 | 1.11022302463e-16 |
| HME1 | AZD2014 | 0.017460717 | 0.1122 | 0.5969 | 0.3948 | -0.3458 | 0.1686 | 0.9585 | 1.11e-16 |
| HME1 | MK 1775 | 0.311734421 | -0.1519 | 0.4391 | 7.7966 | -1.0000 | 0.3413 | 0.9413 | 4.44e-16 |
| HME1 | THZ531 | 0.22121156 | -0.1882 | 0.1768 | 0.2567 | -0.2330 | 2.5689 | 0.9759 | 1.11e-16 |