Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| T47D | PB49673382 | 72 | 3.64102000587 | -0.0634 | 0.3384 | 3.7853 | -0.0626 | 3.0337 |
| T47D | Degrasyn | 72 | 1.65739001923 | -0.6099 | 0.5646 | 2.1976 | -0.5077 | 2.4843 |
| T47D | HY-17542 | 72 | 60.7583842474 | 0.5918 | 0.0384 | 120.2191 | -1.0000 | 1.6099 |
| T47D | Pevonedistat | 72 | 0.0485963385259 | -0.0543 | 0.9154 | 0.0536 | -0.1256 | 2.2893 |
| T47D | SJB2-043 | 72 | 0.418884416082 | -0.3821 | 0.5842 | 0.6165 | -0.3642 | 1.4158 |
| T47D | Vialinin A | 72 | 5.62945811704 | -0.3676 | 0.2949 | 7.5227 | -0.3834 | 1.9635 |
| T47D | GW7647 | 72 | 29.2962645783 | -0.3773 | 0.0975 | 40.0903 | -1.0000 | 3.5024 |
| T47D | HY-17541A | 72 | 6.09725713645 | -0.5568 | 0.3223 | 17.5481 | -1.0000 | 1.0393 |
| T47D | IU1 | 72 | inf | 0.5230 | 0.0543 | 0.0000 | 0.9042 | 0.0100 |
| T47D | ML-323 | 72 | 13.4276900688 | 0.0649 | 0.2011 | 60.0348 | -0.9911 | 0.7296 |
| T47D | SB1-F-21 | 72 | 0.605682620995 | -0.5948 | 0.6994 | 0.9625 | -0.5534 | 1.6087 |
| T47D | SB1-F-22 | 72 | 156.804339896 | 0.7134 | 0.0621 | 286.2396 | -0.2481 | 0.6696 |
| T47D | SJB3-019A | 72 | 0.197447266274 | -0.5628 | 0.9021 | 0.3562 | -0.5619 | 1.2767 |
| T47D | STK547622 | 72 | inf | 0.9428 | 0.0182 | 0.0000 | 0.9914 | 0.0100 |
| T47D | 1247825-37-1 | 72 | 11.5296139364 | -0.2221 | 0.1900 | 12.3560 | -0.2068 | 5.0000 |
| T47D | USP7-IN-1 | 72 | 35.2358506575 | 0.3921 | 0.1491 | 300.7608 | -1.0000 | 0.5124 |
| T47D | HBX19818 | 72 | 19.8447349854 | -0.2828 | 0.1712 | 37.7631 | -1.0000 | 1.7075 |
| T47D | HBX 41108 | 72 | 1.00606977934 | -0.4470 | 0.6172 | 1.2542 | -0.4170 | 2.7516 |
| T47D | HY-50736 | 72 | 0.739108069654 | -0.3225 | 0.6531 | 0.9282 | -0.3566 | 2.3631 |
| T47D | HY-50737A | 72 | 4.05537288518 | -0.2242 | 0.3936 | 4.4286 | -0.2752 | 4.9803 |
| T47D | LDN57444 | 72 | 5.98029149748 | -0.4896 | 0.3206 | 18.7611 | -0.9206 | 0.9133 |
| T47D | MI-2 | 72 | 0.443682151865 | -0.4886 | 0.7738 | 0.5068 | -0.4479 | 4.8114 |
| T47D | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 0.9421 | 0.0700 | 0.0000 | 0.9383 | 0.0100 |
| T47D | b-AP15 | 72 | 0.150241064877 | -0.5598 | 0.9131 | 0.1831 | -0.4234 | 3.0977 |
| T47D | Sepantronium | 72 | 0.0256731457276 | -0.5680 | 1.2354 | 0.0464 | -0.5390 | 1.2377 |