Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| MDA-MB-231 | GW7647 | 72 | inf | 0.9369 | -0.0195 | 0.0000 | 1.0000 | 0.0100 |
| MDA-MB-231 | HBX19818 | 72 | 17.6158530759 | -0.6695 | 0.1856 | 28.5232 | -0.9794 | 2.2510 |
| MDA-MB-231 | HBX 41108 | 72 | 3.79238934604 | -0.3900 | 0.3944 | 5.0207 | -0.4010 | 2.0990 |
| MDA-MB-231 | HY-17541A | 72 | 4.06512520453 | -0.5762 | 0.3840 | 10.2476 | -0.9077 | 1.1195 |
| MDA-MB-231 | HY-17542 | 72 | inf | 0.9016 | 0.0417 | 0.0000 | 0.9547 | 0.0100 |
| MDA-MB-231 | HY-50736 | 72 | 1.15891799404 | -0.4598 | 0.5826 | 1.4403 | -0.4143 | 2.7766 |
| MDA-MB-231 | HY-50737A | 72 | 23.698925903 | 0.0363 | 0.0855 | 26.1146 | -0.1424 | 2.5817 |
| MDA-MB-231 | IU1 | 72 | inf | 0.8503 | 0.0614 | 0.0000 | 0.9320 | 0.0100 |
| MDA-MB-231 | LDN57444 | 72 | 4.94637461912 | -0.0113 | 0.2894 | 4.9647 | -0.0024 | 1.2750 |
| MDA-MB-231 | MI-2 | 72 | 0.537364787333 | -0.5738 | 0.7460 | 0.7155 | -0.5046 | 2.4370 |
| MDA-MB-231 | ML-323 | 72 | 60.8635339383 | 0.5091 | 0.0928 | 299.6220 | -1.0000 | 0.6893 |
| MDA-MB-231 | Pevonedistat | 72 | 0.304844361864 | -0.2071 | 0.6496 | 0.3496 | -0.1395 | 1.7956 |
| MDA-MB-231 | PB49673382 | 72 | 8.96593855475 | -0.0627 | 0.1864 | 9.0711 | -0.0300 | 5.0000 |
| MDA-MB-231 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 1.0514 | 0.0482 | 0.0000 | 0.9659 | 0.0100 |
| MDA-MB-231 | SB1-F-21 | 72 | 0.508989399047 | -0.2031 | 0.6186 | 0.6310 | -0.2064 | 1.6087 |
| MDA-MB-231 | SB1-F-22 | 72 | inf | 0.7278 | 0.0733 | 6.1857 | 0.7300 | 3.3947 |
| MDA-MB-231 | SJB2-043 | 72 | 0.531717815307 | -0.3147 | 0.5316 | 0.6346 | -0.2713 | 2.4513 |
| MDA-MB-231 | SJB3-019A | 72 | 0.347120433929 | -0.3529 | 0.7664 | 0.4218 | -0.3365 | 2.6418 |
| MDA-MB-231 | STK547622 | 72 | inf | 0.9830 | -0.0027 | 0.0000 | 1.0000 | 0.0100 |
| MDA-MB-231 | Vialinin A | 72 | 11.5071057567 | -0.1762 | 0.1553 | 14.2645 | -0.2485 | 1.8785 |
| MDA-MB-231 | Degrasyn | 72 | 1.69752469498 | -0.4482 | 0.5076 | 1.9606 | -0.3779 | 3.9073 |
| MDA-MB-231 | Sepantronium | 72 | 0.00234663809275 | -0.3665 | 1.2531 | 0.0040 | -0.3210 | 0.9233 |
| MDA-MB-231 | b-AP15 | 72 | 0.181306358554 | -0.4204 | 0.8575 | 0.2432 | -0.3944 | 1.9790 |
| MDA-MB-231 | Doxycycline | 72 | inf | 0.7772 | 0.0318 | 0.0000 | 0.9298 | 0.0100 |
| MDA-MB-231 | Mitoxantrone | 72 | 0.000221543574526 | -0.5445 | 1.2292 | 0.0275 | -0.8714 | 0.2093 |