Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| BT-20 | ML-323 | 72 | 211.396631725 | 0.7311 | 0.0653 | 1563.4058 | -1.0000 | 0.5491 |
| HCC1500 | Doxycycline | 72 | 22.0862589106 | -0.3863 | 0.1938 | 36.1548 | -1.0000 | 2.2291 |
| HCC1419 | Pimozide | 72 | 6.13162921953 | -0.7003 | 0.3602 | 13.2581 | -1.0000 | 1.4246 |
| HCC1419 | HY-17541A | 72 | 5.08410753288 | -0.7228 | 0.3771 | 13.2847 | -1.0000 | 1.1438 |
| HCC1954 | HBX19818 | 72 | 22.5984065063 | -0.5316 | 0.1482 | 33.7162 | -1.0000 | 2.7458 |
| HCC202 | Mitoxantrone | 72 | 0.00434457297625 | -0.7112 | 1.2184 | 0.1443 | -1.0000 | 0.3136 |
| HCC1937 | HBX19818 | 72 | 26.0037277737 | -0.0518 | 0.1251 | 48.2744 | -1.0000 | 1.7758 |
| HCC1419 | Mitoxantrone | 72 | 0.0324309949523 | -0.8993 | 1.0606 | 0.5551 | -1.0000 | 0.3868 |
| HCC1428 | HY-17541A | 72 | 2.47757925824 | -0.8052 | 0.5062 | 7.7740 | -1.0000 | 0.9607 |
| HCC1419 | LDN57444 | 72 | 23.1466968338 | -0.3740 | 0.1147 | 36.5806 | -1.0000 | 2.4005 |
| HCC1500 | HY-17541A | 72 | 6.22982678245 | -0.6101 | 0.3035 | 17.0198 | -1.0000 | 1.0931 |
| CAMA-1 | Doxycycline | 72 | 20.1165363681 | -0.1002 | 0.1702 | 44.6977 | -1.0000 | 1.3761 |
| HCC1806 | HY-17541A | 72 | 13.4077616893 | -0.6698 | 0.2684 | 22.7925 | -1.0000 | 2.0705 |
| BT-549 | HY-17541A | 72 | 16.8403527969 | -0.5863 | 0.1928 | 28.1688 | -1.0000 | 2.1356 |
| CAMA-1 | USP7-IN-1 | 72 | 90.407874652 | 0.7005 | 0.0265 | 239.6012 | -1.0000 | 1.1272 |
| HCC1806 | LDN57444 | 72 | 20.8632565992 | -0.2951 | 0.1515 | 37.1169 | -1.0000 | 1.9070 |
| CAMA-1 | HBX19818 | 72 | 24.9121589631 | -0.4378 | 0.1232 | 36.6256 | -1.0000 | 2.8506 |
| BT-549 | USP7-IN-1 | 72 | 94.531181628 | 0.8209 | 0.0177 | 166.1357 | -1.0000 | 1.9483 |
| CAMA-1 | HY-17541A | 72 | 7.52712235452 | -0.7494 | 0.2920 | 17.5656 | -1.0000 | 1.2964 |
| HCC1419 | HBX19818 | 72 | 18.9629402973 | -0.3826 | 0.1144 | 33.7889 | -1.0000 | 1.9019 |
| BT-549 | HBX19818 | 72 | 28.4956034945 | -0.3396 | 0.1206 | 40.2238 | -1.0000 | 3.1871 |
| HCC1428 | HBX19818 | 72 | 11.3560823948 | -0.6631 | 0.2445 | 21.0348 | -1.0000 | 1.7822 |
| HCC1428 | Vialinin A | 72 | 7.02266916467 | -0.5218 | 0.2922 | 19.4033 | -1.0000 | 1.0810 |
| PDXHCI002 | HY-17541A | 72 | 5.47225294247 | -0.5597 | 0.3450 | 15.9936 | -1.0000 | 1.0243 |
| MDA-MB-361 | Mitoxantrone | 72 | 0.00180293182659 | -0.9488 | 1.4412 | 0.0357 | -1.0000 | 0.3678 |