Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| HCC1937 | HBX19818 | 72 | 26.0037277737 | -0.0518 | 0.1251 | 48.2744 | -1.0000 | 1.7758 |
| HCC1937 | GW7647 | 72 | inf | 0.8246 | -0.0146 | 0.0000 | 0.9883 | 0.0100 |
| HCC1937 | USP7-IN-1 | 72 | 65.8738738326 | 0.8119 | -0.0032 | 83.7971 | -0.9000 | 4.2784 |
| HCC1937 | Trifluoperazine | 72 | 10.8581477152 | -0.7147 | 0.2805 | 14.1579 | -0.7487 | 3.4491 |
| HCC1937 | z-VAE(OMe)-fmk | 72 | inf | 0.9933 | -0.0106 | 0.0000 | 1.0000 | 0.0100 |
| HCC1937 | 1247825-37-1 | 72 | 13.156649451 | 0.0110 | 0.1377 | 13.6093 | -0.0392 | 2.2330 |
| HCC1954 | SJB2-043 | 72 | 1.24122713519 | -0.3522 | 0.3712 | 1.3752 | -0.2369 | 3.7831 |
| HCC1954 | SB1-F-22 | 72 | 57.8739615901 | 0.5991 | 0.0409 | 99.2019 | -1.0000 | 2.0387 |
| HCC1954 | SB1-F-21 | 72 | 0.554362808497 | -0.7800 | 0.7854 | 0.7812 | -0.6692 | 2.4761 |
| HCC1954 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 0.8537 | 0.0553 | 0.0000 | 0.9409 | 0.0100 |
| HCC1954 | Pevonedistat | 72 | 0.316056841639 | -0.3881 | 0.7332 | 0.4991 | -0.3610 | 1.1895 |
| HCC1954 | ML-323 | 72 | 85.295133896 | 0.5808 | 0.1325 | 985.9258 | -1.0000 | 0.4489 |
| HCC1954 | MI-2 | 72 | 0.970176713855 | -0.7113 | 0.7248 | 1.1567 | -0.7047 | 5.0000 |
| HCC1954 | LDN57444 | 72 | 18.837326116 | 0.0230 | 0.1849 | 56.1555 | -1.0000 | 1.0058 |
| HCC1954 | IU1 | 72 | inf | 0.7969 | 0.0254 | 8.5142 | 0.7979 | 1.8182 |
| HCC1954 | HY-50737A | 72 | 0.358997904545 | -0.5501 | 0.8394 | 0.6036 | -0.5719 | 1.4677 |
| HCC1954 | HY-50736 | 72 | 0.0820968061449 | -0.4069 | 1.1010 | 0.1207 | -0.5219 | 1.8530 |
| HCC1954 | HY-17542 | 72 | inf | 0.9541 | 0.0043 | 0.0000 | 0.9888 | 0.0100 |
| HCC1954 | HY-17541A | 72 | 4.05518549047 | -0.8364 | 0.4858 | 9.2414 | -1.0000 | 1.3338 |
| HCC1954 | PB49673382 | 72 | 6.08008183847 | -0.0651 | 0.2802 | 6.1946 | -0.0406 | 4.1865 |
| HCC1954 | HBX 41108 | 72 | 0.783598911134 | -0.6088 | 0.6215 | 2.0015 | -0.6718 | 0.9082 |
| HCC1954 | HBX19818 | 72 | 22.5984065063 | -0.5316 | 0.1482 | 33.7162 | -1.0000 | 2.7458 |
| HCC1954 | GW7647 | 72 | 53.2192077737 | 0.5700 | -0.0367 | 66.2968 | -1.0000 | 5.0000 |
| HCC1954 | USP7-IN-1 | 72 | inf | 0.8323 | 0.0313 | 0.0000 | 0.9524 | 0.0100 |
| HCC1954 | 1247825-37-1 | 72 | 9.27208726827 | -0.2049 | 0.2775 | 11.2541 | -0.2697 | 2.2268 |