Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | HY-17542 | 72 | inf | 0.8550 | 0.0387 | 0.0000 | 0.9480 | 0.0100 |
| Hs 578T | STK547622 | 72 | inf | 0.9647 | 0.0155 | 0.0000 | 0.9968 | 0.0100 |
| BT-549 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 0.9516 | 0.0187 | 0.0000 | 0.9793 | 0.0100 |
| SK-BR-3 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 0.9496 | 0.0325 | 0.0000 | 0.9679 | 0.0100 |
| SK-BR-3 | STK547622 | 72 | inf | 0.9373 | 0.0215 | 0.0000 | 0.9814 | 0.0100 |
| BT-20 | z-VAE(OMe)-fmk | 72 | inf | 0.9762 | 0.0198 | 0.0000 | 0.9890 | 0.0100 |
| BT-20 | Doxycycline | 72 | inf | 0.5650 | 0.0355 | 0.0000 | 0.9177 | 0.0100 |
| SK-BR-3 | z-VAE(OMe)-fmk | 72 | inf | 0.9573 | 0.0430 | 0.0000 | 0.9575 | 0.0100 |
| HCC202 | z-VAE(OMe)-fmk | 72 | inf | 1.0085 | 0.0421 | 0.0000 | 0.9739 | 0.0100 |
| BT-20 | STK547622 | 72 | inf | 1.1526 | -0.0532 | 0.0000 | 1.0000 | 0.0100 |
| BT-20 | SB1-F-22 | 72 | inf | 0.8486 | -0.0325 | 0.0000 | 1.0000 | 0.0100 |
| T47D | IU1 | 72 | inf | 0.5230 | 0.0543 | 0.0000 | 0.9042 | 0.0100 |
| BT-20 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 1.0460 | 0.0369 | 0.0000 | 0.9732 | 0.0100 |
| Hs 578T | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 1.0210 | 0.0119 | 0.0000 | 0.9987 | 0.0100 |
| T47D | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 0.9421 | 0.0700 | 0.0000 | 0.9383 | 0.0100 |
| Hs 578T | USP7-IN-1 | 72 | inf | 0.8486 | 0.0005 | 0.0000 | 0.9854 | 0.0100 |
| T47D | STK547622 | 72 | inf | 0.9428 | 0.0182 | 0.0000 | 0.9914 | 0.0100 |
| BT-20 | IU1 | 72 | inf | 1.1490 | -0.1850 | 0.0000 | 1.0000 | 0.0100 |
| Hs 578T | GW7647 | 72 | inf | 0.8977 | -0.0280 | 0.0000 | 1.0000 | 0.0100 |
| BT-20 | HY-17542 | 72 | inf | 1.0099 | -0.0181 | 0.0000 | 1.0000 | 0.0100 |
| Hs 578T | HY-17542 | 72 | inf | 0.9246 | -0.0205 | 0.0000 | 1.0000 | 0.0100 |
| BT-20 | GW7647 | 72 | inf | 0.7093 | -0.0625 | 0.0000 | 1.0000 | 0.0100 |