Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)

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Cell Small Molecule Treatment Duration GR50 GRmax GR_AOC GEC50 GRinf hGR
PDX1328 IU1 72
inf
 0.6034 0.0522 0.0000 0.9321 0.0100
PDX1328 ML-323 72
inf
 0.7525 0.0851 0.0000 0.9071 0.0100
PDX1328 Pevonedistat 72
inf
 -0.7089 -0.4505 0.0000 1.0000 0.0100
PDX1328 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 0.9911 0.0513 0.0000 0.9569 0.0100
HCC202 STK547622 72
inf
 0.8807 0.0217 0.0000 0.9799 0.0100
PDX1328 SB1-F-22 72
inf
 1.0347 -0.2404 0.0000 1.0000 0.0100
PDX1328 STK547622 72
inf
 0.8225 0.0964 0.0000 0.9216 0.0100
CAMA-1 z-VAE(OMe)-fmk 72
inf
 0.9619 0.0262 0.0000 0.9726 0.0100
PDX1328 Doxycycline 72
inf
 1.0834 0.0387 0.0000 0.9720 0.0100
CAMA-1 STK547622 72
inf
 0.8258 0.0467 0.0000 0.9496 0.0100
PDX1328 z-VAE(OMe)-fmk 72
inf
 1.0551 0.0297 0.0000 0.9884 0.0100
PDXHCI002 USP7-IN-1 72
inf
 0.8827 0.0691 0.0000 0.9313 0.0100
PDXHCI002 GW7647 72
inf
 0.7629 -0.0251 0.0000 0.9997 0.0100
PDXHCI002 HY-17542 72
inf
 0.9564 0.0027 0.0000 0.9920 0.0100
CAMA-1 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 0.9375 0.0403 0.0000 0.9497 0.0100
PDXHCI002 IU1 72
inf
 0.7347 0.0713 0.0000 0.9096 0.0100
PDXHCI002 LDN57444 72
inf
 0.3570 0.1453 0.0000 0.8080 0.0100
PDXHCI002 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 0.9950 0.1063 0.0000 0.9127 0.0100
Hs 578T Doxycycline 72
inf
 1.3436 -0.0222 0.0000 1.0000 0.0100
PDXHCI002 STK547622 72
inf
 0.9789 0.0218 0.0000 0.9934 0.0100
CAMA-1 HY-17542 72
inf
 0.8374 0.0179 0.0000 0.9681 0.0100
PDXHCI002 Doxycycline 72
inf
 0.8165 0.0542 0.0000 0.9159 0.0100
BT-549 z-VAE(OMe)-fmk 72
inf
 0.9727 0.0182 0.0000 0.9828 0.0100
PDXHCI002 z-VAE(OMe)-fmk 72
inf
 0.9278 0.0585 0.0000 0.9445 0.0100
BT-549 STK547622 72
inf
 0.9826 0.0068 0.0000 0.9966 0.0100